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• W4304775689 abstract "Abstract We present two methods for enhancing the efficiency of mitochondrial DNA (mtDNA) editing in mice with DddA-derived cytosine base editors (DdCBEs). First, we fused DdCBEs to a nuclear export signal (DdCBE-NES) to avoid off-target C-to-T conversions in the nuclear genome and improve editing efficiency in mtDNA. Second, mtDNA-targeted TALENs (mitoTALENs) are co-injected into mouse embryos to cleave unedited mtDNA. We generated a mouse model with the m.G12918A mutation in the MT-ND5 gene, associated with mitochondrial genetic disorders in humans. The mutant mice show hunched appearances, damaged mitochondria in kidney and brown adipose tissues, and hippocampal atrophy, resulting in premature death." @default.
• W4304775689 created "2022-10-13" @default.
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• W4304775689 date "2022-10-12" @default.
• W4304775689 modified "2023-10-09" @default.
• W4304775689 title "Enhanced mitochondrial DNA editing in mice using nuclear-exported TALE-linked deaminases and nucleases" @default.
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• W4304775689 doi "https://doi.org/10.1186/s13059-022-02782-z" @default.
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