FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304777151> ?p ?o ?g. }

• W4304777151 abstract "Abstract Background The purpose of this study was to explore a new estrogen receptor (ER) and/or progesterone receptor (PR)+ and human epidermal growth factor receptor 2 (HER2)− breast cancer prognostic model, called the extended Cox prognostic model, for determining the cutoff values for multiple continuous prognostic factors and their interaction via the new model concept and variable selection method. Methods A total of 335 patients with ER/PR+ and HER2− breast cancer were enrolled for the final analysis. The primary endpoint was breast cancer-specific mortality (BCSM). Prognostic factors (histological grade, histological type, stage, T, N, lymphovascular invasion (LVI), P53, Ki67, ER, PR, and age) were included in this study. The four continuous variables (Ki67, ER, PR, and age) were partitioned into a series of binary variables that were fitted in the multivariate Cox analysis. A smoothly clipped absolute deviation (SCAD) variable selection method was used. Model performance was expressed in discrimination and calibration. Results We developed an extended Cox model with a time threshold of 164-week (more than 3 years) postoperation and developed a user-friendly nomogram based on our extended Cox model to facilitate clinical application. We found that the cutoff values for PR, Ki67, and age were 20%, 60%, and 41–55 years, respectively. There was an interaction between age and PR for patients aged ≥ 41 years and PR ≥ 20% at 164-week postoperation: the older the patients with ER/PR+, HER2−, and PR ≥ 20% were, the lower the survival and more likely to recur and metastasize exceeding 164 weeks (more than 3 years) after surgery. Conclusions Our study offers guidance on the prognosis of patients with ER/PR+ and HER2− breast cancer in China. The new concept can inform modeling and the determination of cutoff values of prognostic factors in the future." @default.
• W4304777151 created "2022-10-13" @default.
• W4304777151 creator A5033107823 @default.
• W4304777151 creator A5041359548 @default.
• W4304777151 creator A5041466556 @default.
• W4304777151 creator A5057965486 @default.
• W4304777151 creator A5081171656 @default.
• W4304777151 date "2022-10-12" @default.
• W4304777151 modified "2023-10-01" @default.
• W4304777151 title "Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study" @default.
• W4304777151 cites W2106161928 @default.
• W4304777151 cites W2123664981 @default.
• W4304777151 cites W2150134401 @default.
• W4304777151 cites W2161426850 @default.
• W4304777151 cites W2185055660 @default.
• W4304777151 cites W2498119267 @default.
• W4304777151 cites W2593162010 @default.
• W4304777151 cites W2619639925 @default.
• W4304777151 cites W2730002782 @default.
• W4304777151 cites W2751809890 @default.
• W4304777151 cites W2766114272 @default.
• W4304777151 cites W2806209829 @default.
• W4304777151 cites W2913744681 @default.
• W4304777151 cites W2959246726 @default.
• W4304777151 cites W2965857754 @default.
• W4304777151 cites W2980681649 @default.
• W4304777151 cites W2999199169 @default.
• W4304777151 cites W2999521665 @default.
• W4304777151 cites W2999744434 @default.
• W4304777151 cites W3022933292 @default.
• W4304777151 cites W3023294477 @default.
• W4304777151 cites W3027142181 @default.
• W4304777151 cites W3096982133 @default.
• W4304777151 cites W3136401436 @default.
• W4304777151 cites W3179495039 @default.
• W4304777151 cites W3183709358 @default.
• W4304777151 cites W3214875169 @default.
• W4304777151 cites W4200361701 @default.
• W4304777151 cites W4213418594 @default.
• W4304777151 cites W4283029993 @default.
• W4304777151 cites W4289766408 @default.
• W4304777151 doi "https://doi.org/10.1186/s12957-022-02790-0" @default.
• W4304777151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36224558" @default.
• W4304777151 hasPublicationYear "2022" @default.
• W4304777151 type Work @default.
• W4304777151 citedByCount "1" @default.
• W4304777151 countsByYear W43047771512023 @default.
• W4304777151 crossrefType "journal-article" @default.
• W4304777151 hasAuthorship W4304777151A5033107823 @default.
• W4304777151 hasAuthorship W4304777151A5041359548 @default.
• W4304777151 hasAuthorship W4304777151A5041466556 @default.
• W4304777151 hasAuthorship W4304777151A5057965486 @default.
• W4304777151 hasAuthorship W4304777151A5081171656 @default.
• W4304777151 hasBestOaLocation W43047771511 @default.
• W4304777151 hasConcept C10515644 @default.
• W4304777151 hasConcept C121608353 @default.
• W4304777151 hasConcept C126322002 @default.
• W4304777151 hasConcept C143998085 @default.
• W4304777151 hasConcept C146357865 @default.
• W4304777151 hasConcept C151730666 @default.
• W4304777151 hasConcept C164465091 @default.
• W4304777151 hasConcept C2778740770 @default.
• W4304777151 hasConcept C2779013556 @default.
• W4304777151 hasConcept C2780140570 @default.
• W4304777151 hasConcept C29456083 @default.
• W4304777151 hasConcept C34626388 @default.
• W4304777151 hasConcept C50382708 @default.
• W4304777151 hasConcept C530470458 @default.
• W4304777151 hasConcept C71924100 @default.
• W4304777151 hasConcept C84606932 @default.
• W4304777151 hasConcept C86803240 @default.
• W4304777151 hasConcept C98717036 @default.
• W4304777151 hasConceptScore W4304777151C10515644 @default.
• W4304777151 hasConceptScore W4304777151C121608353 @default.
• W4304777151 hasConceptScore W4304777151C126322002 @default.
• W4304777151 hasConceptScore W4304777151C143998085 @default.
• W4304777151 hasConceptScore W4304777151C146357865 @default.
• W4304777151 hasConceptScore W4304777151C151730666 @default.
• W4304777151 hasConceptScore W4304777151C164465091 @default.
• W4304777151 hasConceptScore W4304777151C2778740770 @default.
• W4304777151 hasConceptScore W4304777151C2779013556 @default.
• W4304777151 hasConceptScore W4304777151C2780140570 @default.
• W4304777151 hasConceptScore W4304777151C29456083 @default.
• W4304777151 hasConceptScore W4304777151C34626388 @default.
• W4304777151 hasConceptScore W4304777151C50382708 @default.
• W4304777151 hasConceptScore W4304777151C530470458 @default.
• W4304777151 hasConceptScore W4304777151C71924100 @default.
• W4304777151 hasConceptScore W4304777151C84606932 @default.
• W4304777151 hasConceptScore W4304777151C86803240 @default.
• W4304777151 hasConceptScore W4304777151C98717036 @default.
• W4304777151 hasIssue "1" @default.
• W4304777151 hasLocation W43047771511 @default.
• W4304777151 hasLocation W43047771512 @default.
• W4304777151 hasLocation W43047771513 @default.
• W4304777151 hasLocation W43047771514 @default.
• W4304777151 hasLocation W43047771515 @default.
• W4304777151 hasOpenAccess W4304777151 @default.
• W4304777151 hasPrimaryLocation W43047771511 @default.
• W4304777151 hasRelatedWork W2357456301 @default.
• W4304777151 hasRelatedWork W2415052584 @default.

• next