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- W4304789009 endingPage "107579" @default.
- W4304789009 startingPage "107579" @default.
- W4304789009 abstract "Glyphosate-based herbicides (GBHs) are the most widely used pesticide worldwide and can provoke placental injury. However, whether and how GBHs damage angiogenesis in the placenta is not yet known. This work evaluated the safety of glyphosate on pregnant sows based on the limit level by governments and investigated the effects and mechanism of Low-GBHs (20 mg/kg) and High-GBHs (100 mg/kg) exposure on placental angiogenesis. Results showed that gestational exposure to GBHs decreased placental vessel density and cell multiplication by interfering with the expression of VEGFA, PLGF, VEGFr2 and Hand2 (indicators of angiogenesis), which may be in relation to oxidative stress-induced disorders of mitochondrial fission and fusion as well as the impaired function of the mitochondrial respiratory chain. Additionally, GBHs destroyed barrier function and nutrient transport in the placenta, and was accompanied by jejunum oxidative stress in newborn piglets. However, GBHs exposure had no significant differences on sow reproductive performance. As a natural antioxidant, betaine treatment protected placenta and newborn piglets against GBHs-induced damage. In conclusion, GBHs impaired placental angiogenesis and function and further damaged the health of postnatal progeny, these effects may be linked to mitochondrial dysfunction. Betaine treatment following glyphosate exposure provided modest relief." @default.
- W4304789009 created "2022-10-13" @default.
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- W4304789009 date "2022-12-01" @default.
- W4304789009 modified "2023-10-02" @default.
- W4304789009 title "Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function" @default.
- W4304789009 cites W1125422980 @default.
- W4304789009 cites W1993280571 @default.
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- W4304789009 cites W2016105952 @default.
- W4304789009 cites W2038911217 @default.
- W4304789009 cites W2039072713 @default.
- W4304789009 cites W2042552449 @default.
- W4304789009 cites W2075824452 @default.
- W4304789009 cites W2082221119 @default.
- W4304789009 cites W2091458772 @default.
- W4304789009 cites W2114330412 @default.
- W4304789009 cites W2121636881 @default.
- W4304789009 cites W2134236053 @default.
- W4304789009 cites W2159368754 @default.
- W4304789009 cites W2175816851 @default.
- W4304789009 cites W2345850087 @default.
- W4304789009 cites W2560539847 @default.
- W4304789009 cites W2592471987 @default.
- W4304789009 cites W2751768647 @default.
- W4304789009 cites W2769352204 @default.
- W4304789009 cites W2790467303 @default.
- W4304789009 cites W2795430688 @default.
- W4304789009 cites W2805129852 @default.
- W4304789009 cites W2807400179 @default.
- W4304789009 cites W2808587354 @default.
- W4304789009 cites W2883859393 @default.
- W4304789009 cites W2888156757 @default.
- W4304789009 cites W2896899115 @default.
- W4304789009 cites W2897159855 @default.
- W4304789009 cites W2899281139 @default.
- W4304789009 cites W2900954862 @default.
- W4304789009 cites W2905098339 @default.
- W4304789009 cites W2905933159 @default.
- W4304789009 cites W2911655376 @default.
- W4304789009 cites W2945426393 @default.
- W4304789009 cites W2964040689 @default.
- W4304789009 cites W2965209680 @default.
- W4304789009 cites W2965635787 @default.
- W4304789009 cites W2965935032 @default.
- W4304789009 cites W2978904500 @default.
- W4304789009 cites W2986249524 @default.
- W4304789009 cites W2995189491 @default.
- W4304789009 cites W2999471682 @default.
- W4304789009 cites W3007316850 @default.
- W4304789009 cites W3011013193 @default.
- W4304789009 cites W3014365133 @default.
- W4304789009 cites W3023263933 @default.
- W4304789009 cites W3026766971 @default.
- W4304789009 cites W3028306570 @default.
- W4304789009 cites W3036370233 @default.
- W4304789009 cites W3040855328 @default.
- W4304789009 cites W3044283635 @default.
- W4304789009 cites W3080690654 @default.
- W4304789009 cites W3083975149 @default.
- W4304789009 cites W3123200640 @default.
- W4304789009 cites W3150135269 @default.
- W4304789009 cites W3173454966 @default.
- W4304789009 cites W3177132484 @default.
- W4304789009 cites W3180150802 @default.
- W4304789009 cites W3184041463 @default.
- W4304789009 cites W3185634633 @default.
- W4304789009 cites W3192768255 @default.
- W4304789009 cites W3195394427 @default.
- W4304789009 cites W3199974498 @default.
- W4304789009 cites W37706093 @default.
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- W4304789009 cites W4200436358 @default.
- W4304789009 cites W4200585843 @default.
- W4304789009 cites W4205979599 @default.
- W4304789009 cites W4206327859 @default.
- W4304789009 cites W4220789663 @default.
- W4304789009 cites W4224917920 @default.
- W4304789009 cites W4226225301 @default.
- W4304789009 cites W4228997079 @default.
- W4304789009 doi "https://doi.org/10.1016/j.envint.2022.107579" @default.
- W4304789009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36265358" @default.
- W4304789009 hasPublicationYear "2022" @default.
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