FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304806575> ?p ?o ?g. }

• W4304806575 endingPage "6022" @default.
• W4304806575 startingPage "6022" @default.
• W4304806575 abstract "Background: Oral anticoagulants (OACs) are important in reducing the risk of ischaemic stroke in people with atrial fibrillation (AF). Although patients need to take their OAC continuously, it has been suggested that discontinuation is common in clinical practice, and this could predispose patients to thrombotic complications. Aims: To investigate the rate of OAC discontinuation and its predictors in patients with AF, using national data from Australian general practices. Methods: We analysed data obtained from NPS MedicineWise’s MedicineInsight dataset. We included patients with a recorded diagnosis of AF who newly started an OAC between 1 January 2013 and 31 December 2017. Patients were considered persistent if an OAC was prescribed continuously without discontinuing more than 60 days gap in therapy. The follow-up period was 12 months post-initiation. Multivariable models were used for the analysis of predictors. Results: Of 16,075 patients included in the cohort, 47.3% were females, and the mean age was 74.6 (SD 10.2) years. The overall OAC discontinuation rate was 13.2% (confidence interval (CI) 12.6–13.7%) by 12 months post-initiation. The discontinuation rates for warfarin, apixaban, dabigatran and rivaroxaban were 18.3% (95% CI 17.2–19.5%), 10.1% (95% CI 9.2–11.0%), 10.9% (95% CI 9.4–12.5%) and 12.2% (95% CI 11.4–13.2%), respectively. Warfarin had a significantly higher risk of discontinuation compared to direct-acting OACs. Factors that are known to increase the risk of stroke (older age, diabetes, and hypertension) were associated with better persistence. Conclusions: A relatively high proportion of patients with AF continued OAC therapy by 12 months post-initiation. Positively, patients with the highest risk of stroke and lowest risk of bleeds seemed to have better persistence." @default.
• W4304806575 created "2022-10-13" @default.
• W4304806575 creator A5006038504 @default.
• W4304806575 creator A5025282229 @default.
• W4304806575 creator A5074193099 @default.
• W4304806575 date "2022-10-12" @default.
• W4304806575 modified "2023-10-18" @default.
• W4304806575 title "Oral Anticoagulant Discontinuation and Its Predictors in Patients with Atrial Fibrillation" @default.
• W4304806575 cites W1999468381 @default.
• W4304806575 cites W2020148377 @default.
• W4304806575 cites W2029111709 @default.
• W4304806575 cites W2036193968 @default.
• W4304806575 cites W2152623033 @default.
• W4304806575 cites W2162586165 @default.
• W4304806575 cites W2195719407 @default.
• W4304806575 cites W2329336885 @default.
• W4304806575 cites W2504388219 @default.
• W4304806575 cites W2509795914 @default.
• W4304806575 cites W2516038910 @default.
• W4304806575 cites W2606898993 @default.
• W4304806575 cites W2745269683 @default.
• W4304806575 cites W2761567953 @default.
• W4304806575 cites W2763198394 @default.
• W4304806575 cites W2793896634 @default.
• W4304806575 cites W2902234722 @default.
• W4304806575 cites W2924424410 @default.
• W4304806575 cites W2959873153 @default.
• W4304806575 cites W2967704430 @default.
• W4304806575 cites W2979998872 @default.
• W4304806575 cites W2980772371 @default.
• W4304806575 cites W3004050106 @default.
• W4304806575 cites W3004174354 @default.
• W4304806575 cites W3011777563 @default.
• W4304806575 cites W3012307018 @default.
• W4304806575 cites W3019819364 @default.
• W4304806575 cites W3022287464 @default.
• W4304806575 cites W3107490699 @default.
• W4304806575 cites W3113178943 @default.
• W4304806575 cites W3119217480 @default.
• W4304806575 cites W3133556008 @default.
• W4304806575 cites W3138917052 @default.
• W4304806575 cites W3159673032 @default.
• W4304806575 cites W3188073003 @default.
• W4304806575 cites W4213075745 @default.
• W4304806575 cites W4220698511 @default.
• W4304806575 cites W4229017070 @default.
• W4304806575 cites W4285719527 @default.
• W4304806575 doi "https://doi.org/10.3390/jcm11206022" @default.
• W4304806575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36294344" @default.
• W4304806575 hasPublicationYear "2022" @default.
• W4304806575 type Work @default.
• W4304806575 citedByCount "1" @default.
• W4304806575 countsByYear W43048065752023 @default.
• W4304806575 crossrefType "journal-article" @default.
• W4304806575 hasAuthorship W4304806575A5006038504 @default.
• W4304806575 hasAuthorship W4304806575A5025282229 @default.
• W4304806575 hasAuthorship W4304806575A5074193099 @default.
• W4304806575 hasBestOaLocation W43048065751 @default.
• W4304806575 hasConcept C126322002 @default.
• W4304806575 hasConcept C127413603 @default.
• W4304806575 hasConcept C187212893 @default.
• W4304806575 hasConcept C207103383 @default.
• W4304806575 hasConcept C2776301958 @default.
• W4304806575 hasConcept C2778661090 @default.
• W4304806575 hasConcept C2778715236 @default.
• W4304806575 hasConcept C2778810321 @default.
• W4304806575 hasConcept C2779161974 @default.
• W4304806575 hasConcept C2780638905 @default.
• W4304806575 hasConcept C2780645631 @default.
• W4304806575 hasConcept C44249647 @default.
• W4304806575 hasConcept C71924100 @default.
• W4304806575 hasConcept C72563966 @default.
• W4304806575 hasConcept C78519656 @default.
• W4304806575 hasConceptScore W4304806575C126322002 @default.
• W4304806575 hasConceptScore W4304806575C127413603 @default.
• W4304806575 hasConceptScore W4304806575C187212893 @default.
• W4304806575 hasConceptScore W4304806575C207103383 @default.
• W4304806575 hasConceptScore W4304806575C2776301958 @default.
• W4304806575 hasConceptScore W4304806575C2778661090 @default.
• W4304806575 hasConceptScore W4304806575C2778715236 @default.
• W4304806575 hasConceptScore W4304806575C2778810321 @default.
• W4304806575 hasConceptScore W4304806575C2779161974 @default.
• W4304806575 hasConceptScore W4304806575C2780638905 @default.
• W4304806575 hasConceptScore W4304806575C2780645631 @default.
• W4304806575 hasConceptScore W4304806575C44249647 @default.
• W4304806575 hasConceptScore W4304806575C71924100 @default.
• W4304806575 hasConceptScore W4304806575C72563966 @default.
• W4304806575 hasConceptScore W4304806575C78519656 @default.
• W4304806575 hasIssue "20" @default.
• W4304806575 hasLocation W43048065751 @default.
• W4304806575 hasLocation W43048065752 @default.
• W4304806575 hasLocation W43048065753 @default.
• W4304806575 hasLocation W43048065754 @default.
• W4304806575 hasOpenAccess W4304806575 @default.
• W4304806575 hasPrimaryLocation W43048065751 @default.
• W4304806575 hasRelatedWork W1993190469 @default.
• W4304806575 hasRelatedWork W2016226059 @default.
• W4304806575 hasRelatedWork W2049310472 @default.

• next