FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304808076> ?p ?o ?g. }

• W4304808076 endingPage "21" @default.
• W4304808076 startingPage "1" @default.
• W4304808076 abstract "Cardiac fibrosis is a hallmark of numerous chronic cardiovascular diseases that leads to heart failure. However, there is no validated therapy for it. Dysregulation of microRNAs has been confirmed to be involved in cardiac fibrosis development. However, the regulatory network was not well explored. This study was the first to highlight the role and molecular mechanism of miR-409-3p in cardiac fibrosis. We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor-β (TGF-β). Furthermore, myocardial infarction surgery-induced cardiac fibrosis and dysfunction were attenuated by systemic delivery of miR-409-3p antagomir. Notably, transfection with miR-409-3p mimics promoted the proliferation of cardiac fibroblasts and fibroblast-to-myofibroblast differentiation, accompanied by upregulated expression of Col1a1, Col3a1, and α-SMA. On the contrary, the miR-409-3p inhibitor exhibited the opposite effect. Following this, we verified Gpd1 as a direct target of miR-409-3p. Gpd1 siRNA abolished the antifibrotic effect of miR-409-3p inhibitor in neonatal rat cardiac fibroblasts, suggesting that miR-409-3p promotes cardiac fibrosis at least partially through Gpd1. Moreover, GATA2 was identified as a cardiac fibrosis-associated upstream positive transcription factor of miR-409-3p. Finally, these findings suggest that modulating miR-409-3p could be a potential therapeutic method for cardiac fibrosis." @default.
• W4304808076 created "2022-10-13" @default.
• W4304808076 creator A5016447471 @default.
• W4304808076 creator A5030968272 @default.
• W4304808076 creator A5033229269 @default.
• W4304808076 creator A5053632068 @default.
• W4304808076 creator A5059605550 @default.
• W4304808076 creator A5063150466 @default.
• W4304808076 creator A5065243448 @default.
• W4304808076 creator A5066777288 @default.
• W4304808076 date "2022-10-12" @default.
• W4304808076 modified "2023-10-14" @default.
• W4304808076 title "miR-409-3p Regulated by GATA2 Promotes Cardiac Fibrosis through Targeting Gpd1" @default.
• W4304808076 cites W1963810889 @default.
• W4304808076 cites W2011811777 @default.
• W4304808076 cites W2019624319 @default.
• W4304808076 cites W2126871530 @default.
• W4304808076 cites W2157577168 @default.
• W4304808076 cites W2281422803 @default.
• W4304808076 cites W2299099463 @default.
• W4304808076 cites W2366061453 @default.
• W4304808076 cites W2462759503 @default.
• W4304808076 cites W2481620014 @default.
• W4304808076 cites W2519439122 @default.
• W4304808076 cites W2611990958 @default.
• W4304808076 cites W2736900514 @default.
• W4304808076 cites W2755069190 @default.
• W4304808076 cites W2797797584 @default.
• W4304808076 cites W2802320158 @default.
• W4304808076 cites W2806995606 @default.
• W4304808076 cites W2889069454 @default.
• W4304808076 cites W2914432154 @default.
• W4304808076 cites W2924908935 @default.
• W4304808076 cites W2969284153 @default.
• W4304808076 cites W3055281379 @default.
• W4304808076 cites W3092446447 @default.
• W4304808076 cites W3108647906 @default.
• W4304808076 cites W3113876761 @default.
• W4304808076 cites W3126955501 @default.
• W4304808076 cites W3141836197 @default.
• W4304808076 cites W3155223279 @default.
• W4304808076 cites W3166989955 @default.
• W4304808076 cites W3172607942 @default.
• W4304808076 cites W3181210750 @default.
• W4304808076 cites W3206299744 @default.
• W4304808076 cites W3206379246 @default.
• W4304808076 cites W3212846285 @default.
• W4304808076 cites W3213486495 @default.
• W4304808076 cites W4210834103 @default.
• W4304808076 cites W4214672451 @default.
• W4304808076 doi "https://doi.org/10.1155/2022/8922246" @default.
• W4304808076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36275896" @default.
• W4304808076 hasPublicationYear "2022" @default.
• W4304808076 type Work @default.
• W4304808076 citedByCount "2" @default.
• W4304808076 countsByYear W43048080762023 @default.
• W4304808076 crossrefType "journal-article" @default.
• W4304808076 hasAuthorship W4304808076A5016447471 @default.
• W4304808076 hasAuthorship W4304808076A5030968272 @default.
• W4304808076 hasAuthorship W4304808076A5033229269 @default.
• W4304808076 hasAuthorship W4304808076A5053632068 @default.
• W4304808076 hasAuthorship W4304808076A5059605550 @default.
• W4304808076 hasAuthorship W4304808076A5063150466 @default.
• W4304808076 hasAuthorship W4304808076A5065243448 @default.
• W4304808076 hasAuthorship W4304808076A5066777288 @default.
• W4304808076 hasBestOaLocation W43048080761 @default.
• W4304808076 hasConcept C104317684 @default.
• W4304808076 hasConcept C118131993 @default.
• W4304808076 hasConcept C126322002 @default.
• W4304808076 hasConcept C127561419 @default.
• W4304808076 hasConcept C134018914 @default.
• W4304808076 hasConcept C164705383 @default.
• W4304808076 hasConcept C207865475 @default.
• W4304808076 hasConcept C2777420927 @default.
• W4304808076 hasConcept C2778198053 @default.
• W4304808076 hasConcept C2780559512 @default.
• W4304808076 hasConcept C2908929049 @default.
• W4304808076 hasConcept C3018763269 @default.
• W4304808076 hasConcept C502942594 @default.
• W4304808076 hasConcept C55493867 @default.
• W4304808076 hasConcept C71924100 @default.
• W4304808076 hasConcept C84393581 @default.
• W4304808076 hasConcept C86803240 @default.
• W4304808076 hasConceptScore W4304808076C104317684 @default.
• W4304808076 hasConceptScore W4304808076C118131993 @default.
• W4304808076 hasConceptScore W4304808076C126322002 @default.
• W4304808076 hasConceptScore W4304808076C127561419 @default.
• W4304808076 hasConceptScore W4304808076C134018914 @default.
• W4304808076 hasConceptScore W4304808076C164705383 @default.
• W4304808076 hasConceptScore W4304808076C207865475 @default.
• W4304808076 hasConceptScore W4304808076C2777420927 @default.
• W4304808076 hasConceptScore W4304808076C2778198053 @default.
• W4304808076 hasConceptScore W4304808076C2780559512 @default.
• W4304808076 hasConceptScore W4304808076C2908929049 @default.
• W4304808076 hasConceptScore W4304808076C3018763269 @default.
• W4304808076 hasConceptScore W4304808076C502942594 @default.
• W4304808076 hasConceptScore W4304808076C55493867 @default.
• W4304808076 hasConceptScore W4304808076C71924100 @default.

• next