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- W4304809644 abstract "Supplying sufficient oxygen within the scaffolds is one of the essential hindrances in tissue engineering that can be resolved by oxygen-generating biomaterials (OGBs). Two main issues related to OGBs are controlling oxygenation and reactive oxygen species (ROS). To address these concerns, we developed a composite scaffold entailing three layers (hydrogel-electrospun fibers-hydrogel) with antioxidant and antibacterial properties. The fibers, the middle layer, reinforced the composite structure, enhancing the mechanical strength from 4.27 ± 0.15 to 8.27 ± 0.25 kPa; also, this layer is made of calcium peroxide and silk fibroin (SF) through electrospinning, which enables oxygen delivery. The first and third layers are physical SF hydrogels to control oxygen release, containing quercetin (Q), a nonenzymatic antioxidant. This composite scaffold resulted in almost more than 40 mmHg of oxygen release for at least 13 days, and compared with similar studies is in a high range. Here, Q was used for the first time for an OGB to scavenge the possible ROS. Q delivery not only led to antioxidant activity but also stabilized oxygen release and enhanced cell viability. Based on the given results, this composite scaffold can be introduced as a safe and controllable oxygen supplier, which is promising for tissue engineering applications, particularly for bone." @default.
- W4304809644 created "2022-10-13" @default.
- W4304809644 creator A5015684596 @default.
- W4304809644 creator A5060866855 @default.
- W4304809644 creator A5063404475 @default.
- W4304809644 creator A5073878991 @default.
- W4304809644 date "2022-10-28" @default.
- W4304809644 modified "2023-10-12" @default.
- W4304809644 title "A hydrogel–fiber–hydrogel composite scaffold based on silk fibroin with the dual‐delivery of oxygen and quercetin" @default.
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- W4304809644 doi "https://doi.org/10.1002/bit.28259" @default.
- W4304809644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36224726" @default.
- W4304809644 hasPublicationYear "2022" @default.
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