FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304823265> ?p ?o ?g. }

• W4304823265 abstract "Acute lung injury (ALI) is the primary cause of death among patients with acute paraquat (PQ) poisoning, whereby peroxidative damage is an important mechanism underlying PQ-induced lung injury. There is a lack of effective interventional drugs for patients with PQ poisoning. Oxaloacetic acid (OAA) participates in multiple in vivo metabolic processes, whereby it facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function. The study aimed to assess the protective effects of OAA on PQ-induced ALI and elucidate the underlying molecular mechanism. Our data demonstrated that OAA treatment significantly alleviated PQ-induced ALI and improved the survival rate of PQ-poisoned mice, and also alleviated PQ-induced cellular oxidative stress and mitochondrial dysfunction. OAA-mediated alleviation of PQ-induced mitochondrial dysfunction depends on the following mechanisms which may explain the above findings: 1) OAA effectively cleared intracellular ROS, inhibited ROS accumulation, and mitochondrial depolarization; 2) OAA inhibited the downregulation of L-OPA1 and MFN2 caused by PQ and promoted a dynamic balance of mitochondrial fusion and fission, and 3) the expression of PGC-1α, TFAM, COX2, and COX4I1, increased significantly following OAA intervention which improved mitochondrial respiratory functions and promoted its biogenesis and energy metabolism in damaged cells. In conclusion, OAA effectively cleared ROS and improved mitochondrial dysfunction, thereby significantly improving ALI caused by PQ poisoning and the animal survival rate. Therefore, OAA may be a potential drug for the treatment of PQ poisoning." @default.
• W4304823265 created "2022-10-13" @default.
• W4304823265 creator A5013412329 @default.
• W4304823265 creator A5021412121 @default.
• W4304823265 creator A5023550843 @default.
• W4304823265 creator A5030647879 @default.
• W4304823265 creator A5047441201 @default.
• W4304823265 creator A5069913517 @default.
• W4304823265 creator A5079654043 @default.
• W4304823265 date "2022-10-13" @default.
• W4304823265 modified "2023-09-26" @default.
• W4304823265 title "Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction" @default.
• W4304823265 cites W1474229898 @default.
• W4304823265 cites W1526893351 @default.
• W4304823265 cites W1991700908 @default.
• W4304823265 cites W1996049259 @default.
• W4304823265 cites W2005489861 @default.
• W4304823265 cites W2012698286 @default.
• W4304823265 cites W2061371629 @default.
• W4304823265 cites W2066037623 @default.
• W4304823265 cites W2094823282 @default.
• W4304823265 cites W2105002488 @default.
• W4304823265 cites W2113729748 @default.
• W4304823265 cites W2115813005 @default.
• W4304823265 cites W2121198137 @default.
• W4304823265 cites W2157095173 @default.
• W4304823265 cites W2158088166 @default.
• W4304823265 cites W2260168947 @default.
• W4304823265 cites W2396582749 @default.
• W4304823265 cites W2398874479 @default.
• W4304823265 cites W2538917709 @default.
• W4304823265 cites W2566067391 @default.
• W4304823265 cites W2609730593 @default.
• W4304823265 cites W2610552567 @default.
• W4304823265 cites W2760911695 @default.
• W4304823265 cites W2790190554 @default.
• W4304823265 cites W2807680659 @default.
• W4304823265 cites W2907544909 @default.
• W4304823265 cites W2914229297 @default.
• W4304823265 cites W2964598573 @default.
• W4304823265 cites W2980622391 @default.
• W4304823265 cites W2991361700 @default.
• W4304823265 cites W3010252125 @default.
• W4304823265 cites W3024009267 @default.
• W4304823265 cites W3036228312 @default.
• W4304823265 cites W3100308562 @default.
• W4304823265 cites W3115234271 @default.
• W4304823265 cites W3133079929 @default.
• W4304823265 cites W3167001356 @default.
• W4304823265 cites W4280634319 @default.
• W4304823265 cites W4281642868 @default.
• W4304823265 cites W4283576419 @default.
• W4304823265 cites W4283808060 @default.
• W4304823265 doi "https://doi.org/10.3389/fphar.2022.1029775" @default.
• W4304823265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36313362" @default.
• W4304823265 hasPublicationYear "2022" @default.
• W4304823265 type Work @default.
• W4304823265 citedByCount "0" @default.
• W4304823265 crossrefType "journal-article" @default.
• W4304823265 hasAuthorship W4304823265A5013412329 @default.
• W4304823265 hasAuthorship W4304823265A5021412121 @default.
• W4304823265 hasAuthorship W4304823265A5023550843 @default.
• W4304823265 hasAuthorship W4304823265A5030647879 @default.
• W4304823265 hasAuthorship W4304823265A5047441201 @default.
• W4304823265 hasAuthorship W4304823265A5069913517 @default.
• W4304823265 hasAuthorship W4304823265A5079654043 @default.
• W4304823265 hasBestOaLocation W43048232651 @default.
• W4304823265 hasConcept C104317684 @default.
• W4304823265 hasConcept C13591479 @default.
• W4304823265 hasConcept C163950672 @default.
• W4304823265 hasConcept C185592680 @default.
• W4304823265 hasConcept C190283241 @default.
• W4304823265 hasConcept C24586158 @default.
• W4304823265 hasConcept C2776151105 @default.
• W4304823265 hasConcept C2776527163 @default.
• W4304823265 hasConcept C2777092462 @default.
• W4304823265 hasConcept C2778175917 @default.
• W4304823265 hasConcept C28859421 @default.
• W4304823265 hasConcept C31573885 @default.
• W4304823265 hasConcept C48349386 @default.
• W4304823265 hasConcept C55493867 @default.
• W4304823265 hasConcept C71924100 @default.
• W4304823265 hasConcept C98274493 @default.
• W4304823265 hasConceptScore W4304823265C104317684 @default.
• W4304823265 hasConceptScore W4304823265C13591479 @default.
• W4304823265 hasConceptScore W4304823265C163950672 @default.
• W4304823265 hasConceptScore W4304823265C185592680 @default.
• W4304823265 hasConceptScore W4304823265C190283241 @default.
• W4304823265 hasConceptScore W4304823265C24586158 @default.
• W4304823265 hasConceptScore W4304823265C2776151105 @default.
• W4304823265 hasConceptScore W4304823265C2776527163 @default.
• W4304823265 hasConceptScore W4304823265C2777092462 @default.
• W4304823265 hasConceptScore W4304823265C2778175917 @default.
• W4304823265 hasConceptScore W4304823265C28859421 @default.
• W4304823265 hasConceptScore W4304823265C31573885 @default.
• W4304823265 hasConceptScore W4304823265C48349386 @default.
• W4304823265 hasConceptScore W4304823265C55493867 @default.
• W4304823265 hasConceptScore W4304823265C71924100 @default.
• W4304823265 hasConceptScore W4304823265C98274493 @default.
• W4304823265 hasFunder F4320321001 @default.

• next