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• W4304845411 abstract "Abstract In the early phase of the pandemic, we were among the first to postulate that neutrophil extracellular traps (NETs) play a key role in COVID‐19 pathogenesis. This exploratory prospective study based on 279 individuals showed that plasma levels of neutrophil elastase, myeloperoxidase and circulating DNA of nuclear and mitochondrial origins in nonsevere (NS), severe (S) and postacute phase (PAP) COVID‐19 patients were statistically different as compared to the levels in healthy individuals, and revealed the high diagnostic power of these NETs markers in respect to the disease severity. The diagnostic power of NE, MPO, and cir‐nDNA as determined by the Area Under Receiver Operating Curves (AUROC) was 0.95, 097, and 0.64; 0.99, 1.0, and 0.82; and 0.94, 1.0, and 0.93, in NS, S, and PAP patient subgroups, respectively. In addition, a significant fraction of NS, S as well as of PAP patients exhibited aCL IgM/IgG and anti‐B2GP IgM/IgG positivity. We first demonstrate persistence of these NETs markers in PAP patients and consequently of sustained innate immune response imbalance, and a prolonged low‐level pro‐thrombotic potential activity highlighting the need to monitor these markers in all COVID‐19 PAP individuals, to investigate postacute COVID‐19 pathogenesis following intensive care, and to better identify which medical resources will ensure complete patient recovery." @default.
• W4304845411 created "2022-10-13" @default.
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• W4304845411 date "2022-10-31" @default.
• W4304845411 modified "2023-10-16" @default.
• W4304845411 title "Persistence of neutrophil extracellular traps and anticardiolipin auto‐antibodies in post‐acute phase COVID‐19 patients" @default.
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• W4304845411 doi "https://doi.org/10.1002/jmv.28209" @default.
• W4304845411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36226380" @default.
• W4304845411 hasPublicationYear "2022" @default.
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