FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304889286> ?p ?o ?g. }

• W4304889286 endingPage "100297" @default.
• W4304889286 startingPage "100297" @default.
• W4304889286 abstract "Bile acids (BAs) are steroid detergents in bile that contribute to fat absorption, cell signaling, and microbiome interactions. The final step in their synthesis is amino acid conjugation with either glycine or taurine in the liver by the enzyme bile acid-CoA:amino acid N-acyltransferase (BAAT). Here, we describe the microbial, chemical, and physiological consequences of Baat gene knockout. Baat-/- mice were underweight after weaning but quickly exhibited catch-up growth. At three weeks of age, KO animals had increased phospholipid excretion and decreased subcutaneous fat pad mass, liver mass, glycogen staining in hepatocytes, and hepatic vitamin A stores, but these were less marked in adulthood. Additionally, KO mice had an altered microbiome in early life. Their BA pool was highly enriched in cholic acid but not completely devoid of conjugated BAs. KO animals had 27-fold lower taurine-conjugated BAs than wild type in their liver but similar concentrations of glycine-conjugated BAs and higher microbially conjugated BAs. Furthermore, the BA pool in Baat-/- was enriched in a variety of unusual BAs that were putatively sourced from cysteamine conjugation with subsequent oxidation and methylation of the sulfur group mimicking taurine. Antibiotic treatment of KO mice indicated the microbiome was not the likely source of the unusual conjugations, instead, the unique BAs in KO animals were likely derived from the peroxisomal acyltransferases Acnat1 and Acnat2, which are duplications of Baat in the mouse genome that are inactivated in humans. This study demonstrates that BA conjugation is important for early life development of mice." @default.
• W4304889286 created "2022-10-13" @default.
• W4304889286 creator A5006267438 @default.
• W4304889286 creator A5007769921 @default.
• W4304889286 creator A5017611530 @default.
• W4304889286 creator A5025670982 @default.
• W4304889286 creator A5028928412 @default.
• W4304889286 creator A5035706913 @default.
• W4304889286 creator A5037720831 @default.
• W4304889286 creator A5040736302 @default.
• W4304889286 creator A5042933149 @default.
• W4304889286 creator A5046548770 @default.
• W4304889286 creator A5060900985 @default.
• W4304889286 creator A5070343943 @default.
• W4304889286 creator A5082265227 @default.
• W4304889286 date "2022-12-01" @default.
• W4304889286 modified "2023-10-16" @default.
• W4304889286 title "Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice" @default.
• W4304889286 cites W1513416306 @default.
• W4304889286 cites W1572649633 @default.
• W4304889286 cites W1590993351 @default.
• W4304889286 cites W17370999 @default.
• W4304889286 cites W1969230019 @default.
• W4304889286 cites W1974616640 @default.
• W4304889286 cites W1989299822 @default.
• W4304889286 cites W1995640905 @default.
• W4304889286 cites W2027562091 @default.
• W4304889286 cites W2039550039 @default.
• W4304889286 cites W2040011766 @default.
• W4304889286 cites W2049506766 @default.
• W4304889286 cites W2065051999 @default.
• W4304889286 cites W2078036674 @default.
• W4304889286 cites W2094652347 @default.
• W4304889286 cites W2117457769 @default.
• W4304889286 cites W2134778685 @default.
• W4304889286 cites W2142945080 @default.
• W4304889286 cites W2162904770 @default.
• W4304889286 cites W2168249366 @default.
• W4304889286 cites W2170024099 @default.
• W4304889286 cites W2504691963 @default.
• W4304889286 cites W2518901523 @default.
• W4304889286 cites W2750283291 @default.
• W4304889286 cites W2892206041 @default.
• W4304889286 cites W2986771705 @default.
• W4304889286 cites W3007415664 @default.
• W4304889286 cites W3164721459 @default.
• W4304889286 cites W3168099987 @default.
• W4304889286 cites W3198649369 @default.
• W4304889286 cites W4211168485 @default.
• W4304889286 cites W4286486893 @default.
• W4304889286 doi "https://doi.org/10.1016/j.jlr.2022.100297" @default.
• W4304889286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36243101" @default.
• W4304889286 hasPublicationYear "2022" @default.
• W4304889286 type Work @default.
• W4304889286 citedByCount "4" @default.
• W4304889286 countsByYear W43048892862023 @default.
• W4304889286 crossrefType "journal-article" @default.
• W4304889286 hasAuthorship W4304889286A5006267438 @default.
• W4304889286 hasAuthorship W4304889286A5007769921 @default.
• W4304889286 hasAuthorship W4304889286A5017611530 @default.
• W4304889286 hasAuthorship W4304889286A5025670982 @default.
• W4304889286 hasAuthorship W4304889286A5028928412 @default.
• W4304889286 hasAuthorship W4304889286A5035706913 @default.
• W4304889286 hasAuthorship W4304889286A5037720831 @default.
• W4304889286 hasAuthorship W4304889286A5040736302 @default.
• W4304889286 hasAuthorship W4304889286A5042933149 @default.
• W4304889286 hasAuthorship W4304889286A5046548770 @default.
• W4304889286 hasAuthorship W4304889286A5060900985 @default.
• W4304889286 hasAuthorship W4304889286A5070343943 @default.
• W4304889286 hasAuthorship W4304889286A5082265227 @default.
• W4304889286 hasBestOaLocation W43048892861 @default.
• W4304889286 hasConcept C126322002 @default.
• W4304889286 hasConcept C134018914 @default.
• W4304889286 hasConcept C143121216 @default.
• W4304889286 hasConcept C2775900799 @default.
• W4304889286 hasConcept C2778435403 @default.
• W4304889286 hasConcept C2779399885 @default.
• W4304889286 hasConcept C2779701627 @default.
• W4304889286 hasConcept C515207424 @default.
• W4304889286 hasConcept C55493867 @default.
• W4304889286 hasConcept C60644358 @default.
• W4304889286 hasConcept C71924100 @default.
• W4304889286 hasConcept C86803240 @default.
• W4304889286 hasConceptScore W4304889286C126322002 @default.
• W4304889286 hasConceptScore W4304889286C134018914 @default.
• W4304889286 hasConceptScore W4304889286C143121216 @default.
• W4304889286 hasConceptScore W4304889286C2775900799 @default.
• W4304889286 hasConceptScore W4304889286C2778435403 @default.
• W4304889286 hasConceptScore W4304889286C2779399885 @default.
• W4304889286 hasConceptScore W4304889286C2779701627 @default.
• W4304889286 hasConceptScore W4304889286C515207424 @default.
• W4304889286 hasConceptScore W4304889286C55493867 @default.
• W4304889286 hasConceptScore W4304889286C60644358 @default.
• W4304889286 hasConceptScore W4304889286C71924100 @default.
• W4304889286 hasConceptScore W4304889286C86803240 @default.
• W4304889286 hasFunder F4320310016 @default.
• W4304889286 hasFunder F4320327436 @default.
• W4304889286 hasFunder F4320330944 @default.

• next