Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304889726> ?p ?o ?g. }
- W4304889726 endingPage "263" @default.
- W4304889726 startingPage "250" @default.
- W4304889726 abstract "Amorphous solid dispersions (ASD) are a commonly used enabling formulation technology to drive oral absorption of poorly soluble drugs. To ensure adequate solid-state stability and dissolution characteristics, the ASD formulation design typically has ≤ 25% drug loading. Exposed to aqueous media, ASD formulations can produce drug-rich colloidal dispersion with particle size < 500 nm. This in situ formation of colloidal particles requires incorporation of excess excipients in the formulation. The concept of using engineered drug-rich particles having comparable size as those generated by ASDs in aqueous media is explored with the goal of increasing drug loading in the solid dosage form. Utilizing ABT-530 as model compound, a controlled solvent-antisolvent precipitation method resulted in a dilute suspension that contained drug-rich (90% (w/w)) amorphous nanoparticles (ANP). The precipitation process was optimized to yield a suspension containing < 300 nm ANP. A systematic evaluation of formulation properties and process variables resulted in the generation of dry powders composed of 1–8 µm agglomerates of nanoparticles which in contact with water regenerated the colloidal suspension having particle size comparable to primary particles. Thus, this work demonstrates an approach to designing a re-dispersible ANP based powder containing ≥90% w/w ABT-530 that could be used in preparation of a high drug load solid dosage form." @default.
- W4304889726 created "2022-10-13" @default.
- W4304889726 creator A5006898242 @default.
- W4304889726 creator A5017289651 @default.
- W4304889726 creator A5020255473 @default.
- W4304889726 creator A5028695008 @default.
- W4304889726 creator A5030559999 @default.
- W4304889726 creator A5034753451 @default.
- W4304889726 creator A5065235454 @default.
- W4304889726 date "2023-01-01" @default.
- W4304889726 modified "2023-10-17" @default.
- W4304889726 title "Design of a Re-Dispersible High Drug Load Amorphous Formulation" @default.
- W4304889726 cites W1541736117 @default.
- W4304889726 cites W1963627135 @default.
- W4304889726 cites W1969047331 @default.
- W4304889726 cites W1976021540 @default.
- W4304889726 cites W1981985195 @default.
- W4304889726 cites W1993798865 @default.
- W4304889726 cites W1995360511 @default.
- W4304889726 cites W2005460939 @default.
- W4304889726 cites W2024164228 @default.
- W4304889726 cites W2031448712 @default.
- W4304889726 cites W2035295044 @default.
- W4304889726 cites W2038526752 @default.
- W4304889726 cites W2044762060 @default.
- W4304889726 cites W2049328447 @default.
- W4304889726 cites W2062619217 @default.
- W4304889726 cites W2063812322 @default.
- W4304889726 cites W2071988345 @default.
- W4304889726 cites W2074735522 @default.
- W4304889726 cites W2076770313 @default.
- W4304889726 cites W2077781847 @default.
- W4304889726 cites W2082753849 @default.
- W4304889726 cites W2110604072 @default.
- W4304889726 cites W2130415475 @default.
- W4304889726 cites W2162136831 @default.
- W4304889726 cites W2236510725 @default.
- W4304889726 cites W2253675932 @default.
- W4304889726 cites W2304404543 @default.
- W4304889726 cites W2312885825 @default.
- W4304889726 cites W2330866248 @default.
- W4304889726 cites W2346169493 @default.
- W4304889726 cites W2412497043 @default.
- W4304889726 cites W2605644220 @default.
- W4304889726 cites W2740235667 @default.
- W4304889726 cites W2759450909 @default.
- W4304889726 cites W2767999118 @default.
- W4304889726 cites W2793248366 @default.
- W4304889726 cites W2895658037 @default.
- W4304889726 cites W2900438200 @default.
- W4304889726 cites W2907769684 @default.
- W4304889726 cites W2909187207 @default.
- W4304889726 cites W2911693126 @default.
- W4304889726 cites W2913392672 @default.
- W4304889726 cites W2939818942 @default.
- W4304889726 cites W2942299854 @default.
- W4304889726 cites W2997061680 @default.
- W4304889726 cites W3083482315 @default.
- W4304889726 cites W3152602034 @default.
- W4304889726 cites W2555239487 @default.
- W4304889726 doi "https://doi.org/10.1016/j.xphs.2022.10.002" @default.
- W4304889726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36243131" @default.
- W4304889726 hasPublicationYear "2023" @default.
- W4304889726 type Work @default.
- W4304889726 citedByCount "2" @default.
- W4304889726 countsByYear W43048897262023 @default.
- W4304889726 crossrefType "journal-article" @default.
- W4304889726 hasAuthorship W4304889726A5006898242 @default.
- W4304889726 hasAuthorship W4304889726A5017289651 @default.
- W4304889726 hasAuthorship W4304889726A5020255473 @default.
- W4304889726 hasAuthorship W4304889726A5028695008 @default.
- W4304889726 hasAuthorship W4304889726A5030559999 @default.
- W4304889726 hasAuthorship W4304889726A5034753451 @default.
- W4304889726 hasAuthorship W4304889726A5065235454 @default.
- W4304889726 hasConcept C105341887 @default.
- W4304889726 hasConcept C107054158 @default.
- W4304889726 hasConcept C111368507 @default.
- W4304889726 hasConcept C120665830 @default.
- W4304889726 hasConcept C121332964 @default.
- W4304889726 hasConcept C127313418 @default.
- W4304889726 hasConcept C127413603 @default.
- W4304889726 hasConcept C129955480 @default.
- W4304889726 hasConcept C14029885 @default.
- W4304889726 hasConcept C153294291 @default.
- W4304889726 hasConcept C155574463 @default.
- W4304889726 hasConcept C155672457 @default.
- W4304889726 hasConcept C159985019 @default.
- W4304889726 hasConcept C171250308 @default.
- W4304889726 hasConcept C177562468 @default.
- W4304889726 hasConcept C178790620 @default.
- W4304889726 hasConcept C184651966 @default.
- W4304889726 hasConcept C185592680 @default.
- W4304889726 hasConcept C187530423 @default.
- W4304889726 hasConcept C192562407 @default.
- W4304889726 hasConcept C202444582 @default.
- W4304889726 hasConcept C2778517922 @default.
- W4304889726 hasConcept C2781430271 @default.
- W4304889726 hasConcept C33923547 @default.