Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304890930> ?p ?o ?g. }
- W4304890930 abstract "Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the pathogenesis of choroidal neovascularization (CNV) in exudative AMD (wet AMD). This study describes the effects of cyclooxygenase-2 (COX2)/prostaglandin E2 (PGE2) signalling on the macrophage activation and CNV formation of wet AMD. In a mouse model of laser-induced wet AMD, the mice received an intravitreal injection of celecoxib (a selective COX2 inhibitor). Optical coherence tomography (OCT), fundus fluorescein angiography (FFA), choroidal histology of the CNV lesions, and biochemical markers were assessed. The level of PGE2 expression was high in the laser-induced CNV lesions. Macrophage recruitment and CNV development were significantly less after celecoxib treatment. E-prostanoid1 receptor (EP1R)/protein kinase C (PKC) signalling was involved in M2 macrophage activation and interleukin-10 (IL-10) production of bone marrow-derived macrophages (BMDMs) in vitro. In addition, IL-10 was found to induce the proliferation and migration of human choroidal microvascular endothelial cells (HCECs). Thus, the PGE2/EP1R signalling network serves as a potential therapeutic target for CNV of the wet-type AMD. Video abstract." @default.
- W4304890930 created "2022-10-13" @default.
- W4304890930 creator A5021469218 @default.
- W4304890930 creator A5022801075 @default.
- W4304890930 creator A5023992585 @default.
- W4304890930 creator A5025574128 @default.
- W4304890930 creator A5031115326 @default.
- W4304890930 creator A5031124275 @default.
- W4304890930 creator A5039683428 @default.
- W4304890930 creator A5049597377 @default.
- W4304890930 creator A5055465821 @default.
- W4304890930 creator A5072978209 @default.
- W4304890930 creator A5074581152 @default.
- W4304890930 creator A5078568246 @default.
- W4304890930 creator A5087398659 @default.
- W4304890930 date "2022-10-13" @default.
- W4304890930 modified "2023-10-13" @default.
- W4304890930 title "PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models" @default.
- W4304890930 cites W1560930668 @default.
- W4304890930 cites W1775759920 @default.
- W4304890930 cites W1964948989 @default.
- W4304890930 cites W2019268443 @default.
- W4304890930 cites W2020744745 @default.
- W4304890930 cites W2037869487 @default.
- W4304890930 cites W2088593568 @default.
- W4304890930 cites W2123878459 @default.
- W4304890930 cites W2158262152 @default.
- W4304890930 cites W2179432351 @default.
- W4304890930 cites W2190420537 @default.
- W4304890930 cites W2233199907 @default.
- W4304890930 cites W2315613727 @default.
- W4304890930 cites W2569281233 @default.
- W4304890930 cites W2589417015 @default.
- W4304890930 cites W2763114619 @default.
- W4304890930 cites W2787548271 @default.
- W4304890930 cites W2889981326 @default.
- W4304890930 cites W2900389483 @default.
- W4304890930 cites W2928954057 @default.
- W4304890930 cites W2950292113 @default.
- W4304890930 cites W2953741594 @default.
- W4304890930 cites W2985941554 @default.
- W4304890930 cites W3012266630 @default.
- W4304890930 cites W3012834768 @default.
- W4304890930 cites W3013522609 @default.
- W4304890930 cites W3091804993 @default.
- W4304890930 cites W3109573151 @default.
- W4304890930 cites W3117028850 @default.
- W4304890930 cites W3133213699 @default.
- W4304890930 cites W3148040349 @default.
- W4304890930 cites W4237713631 @default.
- W4304890930 doi "https://doi.org/10.1186/s12964-022-00973-6" @default.
- W4304890930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36229856" @default.
- W4304890930 hasPublicationYear "2022" @default.
- W4304890930 type Work @default.
- W4304890930 citedByCount "2" @default.
- W4304890930 countsByYear W43048909302023 @default.
- W4304890930 crossrefType "journal-article" @default.
- W4304890930 hasAuthorship W4304890930A5021469218 @default.
- W4304890930 hasAuthorship W4304890930A5022801075 @default.
- W4304890930 hasAuthorship W4304890930A5023992585 @default.
- W4304890930 hasAuthorship W4304890930A5025574128 @default.
- W4304890930 hasAuthorship W4304890930A5031115326 @default.
- W4304890930 hasAuthorship W4304890930A5031124275 @default.
- W4304890930 hasAuthorship W4304890930A5039683428 @default.
- W4304890930 hasAuthorship W4304890930A5049597377 @default.
- W4304890930 hasAuthorship W4304890930A5055465821 @default.
- W4304890930 hasAuthorship W4304890930A5072978209 @default.
- W4304890930 hasAuthorship W4304890930A5074581152 @default.
- W4304890930 hasAuthorship W4304890930A5078568246 @default.
- W4304890930 hasAuthorship W4304890930A5087398659 @default.
- W4304890930 hasBestOaLocation W43048909301 @default.
- W4304890930 hasConcept C118487528 @default.
- W4304890930 hasConcept C126322002 @default.
- W4304890930 hasConcept C142724271 @default.
- W4304890930 hasConcept C202751555 @default.
- W4304890930 hasConcept C2776403814 @default.
- W4304890930 hasConcept C2777956040 @default.
- W4304890930 hasConcept C2778271429 @default.
- W4304890930 hasConcept C2779244956 @default.
- W4304890930 hasConcept C2780394083 @default.
- W4304890930 hasConcept C2781359195 @default.
- W4304890930 hasConcept C502942594 @default.
- W4304890930 hasConcept C55493867 @default.
- W4304890930 hasConcept C71924100 @default.
- W4304890930 hasConcept C86803240 @default.
- W4304890930 hasConceptScore W4304890930C118487528 @default.
- W4304890930 hasConceptScore W4304890930C126322002 @default.
- W4304890930 hasConceptScore W4304890930C142724271 @default.
- W4304890930 hasConceptScore W4304890930C202751555 @default.
- W4304890930 hasConceptScore W4304890930C2776403814 @default.
- W4304890930 hasConceptScore W4304890930C2777956040 @default.
- W4304890930 hasConceptScore W4304890930C2778271429 @default.
- W4304890930 hasConceptScore W4304890930C2779244956 @default.
- W4304890930 hasConceptScore W4304890930C2780394083 @default.
- W4304890930 hasConceptScore W4304890930C2781359195 @default.
- W4304890930 hasConceptScore W4304890930C502942594 @default.
- W4304890930 hasConceptScore W4304890930C55493867 @default.
- W4304890930 hasConceptScore W4304890930C71924100 @default.
- W4304890930 hasConceptScore W4304890930C86803240 @default.
- W4304890930 hasFunder F4320321001 @default.