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- W4304891978 abstract "The discovery and development of effective drugs for cancer patients has seen limited success in the clinic from phase I trials onward. The high attrition rate of current drug development approaches requires careful evaluation to provide a better understanding of the factors that correlate with or predict positive clinical outcomes. Here, we examine pre-clinical drug development approaches and conduct a meta-analysis of 2918 clinical studies involving 466 unique drugs tested in clinical trials for acute myeloid leukemia (AML). Our goal was to determine whether there are key shared pre-clinical characteristics that ultimately relate to successful or unsuccessful drugs in patients. We provide an evidence-based recommendation for the use of phenotypic drug discovery rather than other methods during pre-clinical development. Although our analysis was limited to AML, similar analyses are likely to be informative for other tumor-specific drug discovery campaigns, informing and improving the foundational discovery screens and platforms for other cancers." @default.
- W4304891978 created "2022-10-13" @default.
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- W4304891978 date "2022-12-01" @default.
- W4304891978 modified "2023-09-27" @default.
- W4304891978 title "Evidence-based support for phenotypic drug discovery in acute myeloid leukemia" @default.
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- W4304891978 doi "https://doi.org/10.1016/j.drudis.2022.103407" @default.
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