FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304974639> ?p ?o ?g. }

• W4304974639 abstract "Abstract The opportunistic pathogen Pseudomonas aeruginosa PAO1 is infected by the filamentous bacteriophage Pf4. Pf4 virions promote biofilm formation, protect bacteria from antibiotics, and modulate animal immune responses in ways that promote infection. Furthermore, strains cured of their Pf4 infection (ΔPf4) are less virulent in animal models of infection. Consistently, we find that strain ΔPf4 is less virulent in a Caenorhabditis elegans nematode infection model. However, our data indicate that PQS quorum sensing is activated and production of the pigment pyocyanin, a potent virulence factor, is enhanced in strain ΔPf4. The reduced virulence of ΔPf4 despite high levels of pyocyanin production may be explained by our finding that C. elegans mutants unable to sense bacterial pigments through the aryl hydrocarbon receptor are more susceptible to ΔPf4 infection compared to wild-type C. elegans . Collectively, our data support a model where suppression of quorum-regulated virulence factors by Pf4 allows P. aeruginosa to evade detection by innate host immune responses. Author Summary Pseudomonas aeruginosa is an opportunistic bacterial pathogen that infects wounds, lungs, and medical hardware. P. aeruginosa strains are often themselves infected by a filamentous virus (phage) called Pf. At sites of infection, filamentous Pf virions are produced that promote bacterial colonization and virulence. Here, we report that strains of P. aeruginosa cured of their Pf infection are less virulent in a Caenorhabditis elegans nematode infection model. We also report that PQS quorum sensing and production of the virulence factor pyocyanin are enhanced in P. aeruginosa strains cured of their Pf infection. Compared to wild-type C. elegans , nematodes unable to detect bacterial pigments via the aryl hydrocarbon receptor AhR were more susceptible to infection by Pf-free P. aeruginosa strains that over-produce pyocyanin. Collectively, this study supports a model where Pf phage suppress P. aeruginosa PQS quorum sensing and reduce pyocyanin production, allowing P. aeruginosa to evade AhR-mediated immune responses in C. elegans ." @default.
• W4304974639 created "2022-10-14" @default.
• W4304974639 creator A5016540184 @default.
• W4304974639 creator A5016942503 @default.
• W4304974639 creator A5020817631 @default.
• W4304974639 creator A5029001128 @default.
• W4304974639 creator A5033862891 @default.
• W4304974639 creator A5037073236 @default.
• W4304974639 creator A5069433595 @default.
• W4304974639 creator A5070485611 @default.
• W4304974639 creator A5091278593 @default.
• W4304974639 date "2022-10-13" @default.
• W4304974639 modified "2023-10-16" @default.
• W4304974639 title "Tripartite interactions between filamentous Pf4 bacteriophage,<i>Pseudomonas aeruginosa</i>, and bacterivorous nematodes" @default.
• W4304974639 cites W1977151336 @default.
• W4304974639 cites W1998714639 @default.
• W4304974639 cites W2000461931 @default.
• W4304974639 cites W2007002493 @default.
• W4304974639 cites W2010354989 @default.
• W4304974639 cites W2043091055 @default.
• W4304974639 cites W2045015262 @default.
• W4304974639 cites W2064612941 @default.
• W4304974639 cites W2075763186 @default.
• W4304974639 cites W2080380824 @default.
• W4304974639 cites W2080410350 @default.
• W4304974639 cites W2081771295 @default.
• W4304974639 cites W2085034589 @default.
• W4304974639 cites W2086358238 @default.
• W4304974639 cites W2087371604 @default.
• W4304974639 cites W2087435147 @default.
• W4304974639 cites W2090922420 @default.
• W4304974639 cites W2101207404 @default.
• W4304974639 cites W2108993923 @default.
• W4304974639 cites W2109942408 @default.
• W4304974639 cites W2113771246 @default.
• W4304974639 cites W2120137321 @default.
• W4304974639 cites W2126918333 @default.
• W4304974639 cites W2138502991 @default.
• W4304974639 cites W2145457819 @default.
• W4304974639 cites W2151034892 @default.
• W4304974639 cites W2155411515 @default.
• W4304974639 cites W2157577107 @default.
• W4304974639 cites W2167580004 @default.
• W4304974639 cites W2168687873 @default.
• W4304974639 cites W2226840781 @default.
• W4304974639 cites W245062617 @default.
• W4304974639 cites W2529210292 @default.
• W4304974639 cites W2537640393 @default.
• W4304974639 cites W2611331868 @default.
• W4304974639 cites W2736238444 @default.
• W4304974639 cites W2796480696 @default.
• W4304974639 cites W2889793193 @default.
• W4304974639 cites W2894901271 @default.
• W4304974639 cites W2922784940 @default.
• W4304974639 cites W2930497553 @default.
• W4304974639 cites W2949471050 @default.
• W4304974639 cites W2963011827 @default.
• W4304974639 cites W2996221411 @default.
• W4304974639 cites W3007468112 @default.
• W4304974639 cites W3008492600 @default.
• W4304974639 cites W3014539628 @default.
• W4304974639 cites W3014777536 @default.
• W4304974639 cites W3036109526 @default.
• W4304974639 cites W3042744893 @default.
• W4304974639 cites W3045898304 @default.
• W4304974639 cites W3047121869 @default.
• W4304974639 cites W3086843167 @default.
• W4304974639 cites W3106948039 @default.
• W4304974639 cites W3113307687 @default.
• W4304974639 cites W3118904292 @default.
• W4304974639 cites W3133755711 @default.
• W4304974639 cites W3209545809 @default.
• W4304974639 cites W4205925420 @default.
• W4304974639 cites W4206190699 @default.
• W4304974639 cites W4213292786 @default.
• W4304974639 cites W4220701345 @default.
• W4304974639 cites W4225255091 @default.
• W4304974639 cites W4281285734 @default.
• W4304974639 cites W4281402019 @default.
• W4304974639 cites W4283264380 @default.
• W4304974639 doi "https://doi.org/10.1101/2022.10.11.511824" @default.
• W4304974639 hasPublicationYear "2022" @default.
• W4304974639 type Work @default.
• W4304974639 citedByCount "0" @default.
• W4304974639 crossrefType "posted-content" @default.
• W4304974639 hasAuthorship W4304974639A5016540184 @default.
• W4304974639 hasAuthorship W4304974639A5016942503 @default.
• W4304974639 hasAuthorship W4304974639A5020817631 @default.
• W4304974639 hasAuthorship W4304974639A5029001128 @default.
• W4304974639 hasAuthorship W4304974639A5033862891 @default.
• W4304974639 hasAuthorship W4304974639A5037073236 @default.
• W4304974639 hasAuthorship W4304974639A5069433595 @default.
• W4304974639 hasAuthorship W4304974639A5070485611 @default.
• W4304974639 hasAuthorship W4304974639A5091278593 @default.
• W4304974639 hasBestOaLocation W43049746391 @default.
• W4304974639 hasConcept C104317684 @default.
• W4304974639 hasConcept C118687296 @default.
• W4304974639 hasConcept C159047783 @default.
• W4304974639 hasConcept C203014093 @default.
• W4304974639 hasConcept C2776441376 @default.

• next