Matches in SemOpenAlex for { <https://semopenalex.org/work/W4304975655> ?p ?o ?g. }
- W4304975655 abstract "Overexposure to manganese disrupts cellular energy metabolism across species, but the molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report that excess cellular manganese selectively disrupts coenzyme Q (CoQ) biosynthesis, resulting in failure of mitochondrial bioenergetics. While respiratory chain complexes remain intact, the lack of CoQ as lipophilic electron carrier precludes oxidative phosphorylation and leads to premature cell and organismal death. At a molecular level, manganese overload causes mismetallation and proteolytic degradation of Coq7, a diiron hydroxylase that catalyzes the penultimate step in CoQ biosynthesis. Coq7 overexpression or supplementation with a CoQ headgroup analog that bypasses Coq7 function fully corrects electron transport, thus restoring respiration and viability. We uncover a unique sensitivity of a diiron enzyme to mismetallation and define the molecular mechanism for manganese-induced bioenergetic failure that is conserved across species." @default.
- W4304975655 created "2022-10-14" @default.
- W4304975655 creator A5002707395 @default.
- W4304975655 creator A5006990661 @default.
- W4304975655 creator A5007498427 @default.
- W4304975655 creator A5013192703 @default.
- W4304975655 creator A5021103379 @default.
- W4304975655 creator A5030308438 @default.
- W4304975655 creator A5031647494 @default.
- W4304975655 creator A5042492366 @default.
- W4304975655 creator A5042683391 @default.
- W4304975655 creator A5046438819 @default.
- W4304975655 creator A5057680116 @default.
- W4304975655 creator A5065101054 @default.
- W4304975655 creator A5071685524 @default.
- W4304975655 creator A5079003851 @default.
- W4304975655 date "2022-10-13" @default.
- W4304975655 modified "2023-10-18" @default.
- W4304975655 title "Manganese-driven CoQ deficiency" @default.
- W4304975655 cites W1201649467 @default.
- W4304975655 cites W1511264100 @default.
- W4304975655 cites W1556836946 @default.
- W4304975655 cites W1587799155 @default.
- W4304975655 cites W1589230152 @default.
- W4304975655 cites W1606049883 @default.
- W4304975655 cites W1963917155 @default.
- W4304975655 cites W1964075908 @default.
- W4304975655 cites W1965060083 @default.
- W4304975655 cites W1975068341 @default.
- W4304975655 cites W1979088319 @default.
- W4304975655 cites W1991570207 @default.
- W4304975655 cites W1992822924 @default.
- W4304975655 cites W1996119078 @default.
- W4304975655 cites W2001298782 @default.
- W4304975655 cites W2012291035 @default.
- W4304975655 cites W2019190661 @default.
- W4304975655 cites W2027037270 @default.
- W4304975655 cites W2035317443 @default.
- W4304975655 cites W2036512300 @default.
- W4304975655 cites W2039340367 @default.
- W4304975655 cites W2041543608 @default.
- W4304975655 cites W2051662235 @default.
- W4304975655 cites W2059869891 @default.
- W4304975655 cites W2064186839 @default.
- W4304975655 cites W2077883858 @default.
- W4304975655 cites W2078223676 @default.
- W4304975655 cites W2080990858 @default.
- W4304975655 cites W2084225035 @default.
- W4304975655 cites W2089824746 @default.
- W4304975655 cites W2092143550 @default.
- W4304975655 cites W2107277218 @default.
- W4304975655 cites W2111006624 @default.
- W4304975655 cites W2115327051 @default.
- W4304975655 cites W2121966499 @default.
- W4304975655 cites W2123399767 @default.
- W4304975655 cites W2126096987 @default.
- W4304975655 cites W2137209776 @default.
- W4304975655 cites W2147431408 @default.
- W4304975655 cites W2149269883 @default.
- W4304975655 cites W2154046032 @default.
- W4304975655 cites W2156442455 @default.
- W4304975655 cites W2167279371 @default.
- W4304975655 cites W2192080449 @default.
- W4304975655 cites W2325211585 @default.
- W4304975655 cites W2326368454 @default.
- W4304975655 cites W2516255022 @default.
- W4304975655 cites W2585611321 @default.
- W4304975655 cites W2606492382 @default.
- W4304975655 cites W2607261273 @default.
- W4304975655 cites W2754373993 @default.
- W4304975655 cites W2782493592 @default.
- W4304975655 cites W2791899259 @default.
- W4304975655 cites W2793385742 @default.
- W4304975655 cites W2909659351 @default.
- W4304975655 cites W2915920304 @default.
- W4304975655 cites W2921671377 @default.
- W4304975655 cites W2948676018 @default.
- W4304975655 cites W2948933646 @default.
- W4304975655 cites W2986323652 @default.
- W4304975655 cites W2999209781 @default.
- W4304975655 cites W3010310070 @default.
- W4304975655 cites W3010728570 @default.
- W4304975655 cites W3010809349 @default.
- W4304975655 cites W3012380876 @default.
- W4304975655 cites W3012843216 @default.
- W4304975655 cites W3013601849 @default.
- W4304975655 cites W3017638657 @default.
- W4304975655 cites W3022955034 @default.
- W4304975655 cites W3037936818 @default.
- W4304975655 cites W3083145782 @default.
- W4304975655 cites W3085499101 @default.
- W4304975655 cites W3091367579 @default.
- W4304975655 cites W3135132206 @default.
- W4304975655 cites W3177828909 @default.
- W4304975655 cites W3203646767 @default.
- W4304975655 cites W4200235700 @default.
- W4304975655 cites W4251139549 @default.
- W4304975655 cites W4281478641 @default.
- W4304975655 cites W99972145 @default.
- W4304975655 doi "https://doi.org/10.1038/s41467-022-33641-x" @default.