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- W4305013886 startingPage "3805" @default.
- W4305013886 abstract "The role of the lateral prefrontal cortex (lPFC) in working memory (WM) is debated. Non-human primate (NHP) electrophysiology shows that the lPFC stores WM representations, but human neuroimaging suggests that the lPFC controls WM content in sensory cortices. These accounts are confounded by differences in task training and stimulus exposure. We tested whether long-term training alters lPFC function by densely sampling WM activity using functional MRI. Over 3 months, participants trained on both a WM and serial reaction time (SRT) task, wherein fractal stimuli were embedded within sequences. WM performance improved for trained (but not novel) fractals and, neurally, delay activity increased in distributed lPFC voxels across learning. Item-level WM representations became detectable within lPFC patterns, and lPFC activity reflected sequence relationships from the SRT task. These findings demonstrate that human lPFC develops stimulus-selective responses with learning, and WM representations are shaped by long-term experience, which could reconcile competing accounts of WM functioning." @default.
- W4305013886 created "2022-10-14" @default.
- W4305013886 creator A5009399004 @default.
- W4305013886 creator A5027119999 @default.
- W4305013886 creator A5046805836 @default.
- W4305013886 creator A5085795796 @default.
- W4305013886 date "2022-11-01" @default.
- W4305013886 modified "2023-10-17" @default.
- W4305013886 title "Long-term learning transforms prefrontal cortex representations during working memory" @default.
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