Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306146735> ?p ?o ?g. }
- W4306146735 endingPage "12" @default.
- W4306146735 startingPage "1" @default.
- W4306146735 abstract "ALDH1A3 and Linc00284 involve in colorectal cancer (CRC) development; however, the regulatory mechanism is still unclear. In this study, we collected clinicopathological characteristics and tissue samples from 73 CRC patients to analyze the expression of ALDH1A3, Linc00284, TGFβ signaling and miR-361-5p using qPCR, Western blotting, and ELISA. Multiple CRC cell lines were evaluated in this study, and the highest level of ALDH1A3 was observed in SW480 cells. To investigate the regulatory mechanism, RIP and luciferase assays were used to validate the interaction between Linc00284, miR-361-5p, and TGFβ. Proliferation, viability, migration, and invasion assays were performed to profile the effects of the ALDH1A3-Linc00284 axis in CRC cell functions, which was upregulated in CRC tissues. Knockdown ALDH1A3 or Linc00284 significantly reduced TGFβ expression and suppressed the EMT process, while overexpression had opposite effects. miR-361-5p targeted TGFβ directly, which negatively correlated with ALDH1A3-Linc00284 expression and CRC progression. Mechanistically, upregulation of ALDH1A3-Linc00284 promotes colorectal cancer invasion and migration by regulating miR-361-5p/TGFβ signaling pathway. Dysregulation of the ALDH1A3-Linc00284-miR-361-5p-TGFβ axis causes CRC invasion, which might provide a new insight into the treatment of CRC." @default.
- W4306146735 created "2022-10-14" @default.
- W4306146735 creator A5006221281 @default.
- W4306146735 creator A5040444759 @default.
- W4306146735 creator A5045226074 @default.
- W4306146735 creator A5053766095 @default.
- W4306146735 creator A5053911309 @default.
- W4306146735 creator A5055537356 @default.
- W4306146735 date "2022-10-13" @default.
- W4306146735 modified "2023-09-25" @default.
- W4306146735 title "ALDH1A3–Linc00284 Axis Mediates the Invasion of Colorectal Cancer by Targeting TGFβ Signaling via Sponging miR-361-5p" @default.
- W4306146735 cites W1686076540 @default.
- W4306146735 cites W1760215417 @default.
- W4306146735 cites W2153268494 @default.
- W4306146735 cites W2153284298 @default.
- W4306146735 cites W2462565408 @default.
- W4306146735 cites W2516839465 @default.
- W4306146735 cites W2607024430 @default.
- W4306146735 cites W2611950171 @default.
- W4306146735 cites W2736520162 @default.
- W4306146735 cites W2755894917 @default.
- W4306146735 cites W2771379749 @default.
- W4306146735 cites W2776134130 @default.
- W4306146735 cites W2779416336 @default.
- W4306146735 cites W2783102652 @default.
- W4306146735 cites W2883015258 @default.
- W4306146735 cites W2888555176 @default.
- W4306146735 cites W2920863623 @default.
- W4306146735 cites W2951131565 @default.
- W4306146735 cites W2955768353 @default.
- W4306146735 cites W2969253527 @default.
- W4306146735 cites W2978386835 @default.
- W4306146735 cites W2991940027 @default.
- W4306146735 cites W3000964475 @default.
- W4306146735 cites W3009963727 @default.
- W4306146735 cites W3010114444 @default.
- W4306146735 cites W3014481596 @default.
- W4306146735 cites W3016840787 @default.
- W4306146735 cites W3100422985 @default.
- W4306146735 cites W3149319944 @default.
- W4306146735 cites W3165431420 @default.
- W4306146735 cites W3180907046 @default.
- W4306146735 cites W3199575523 @default.
- W4306146735 cites W4206570434 @default.
- W4306146735 cites W4211233744 @default.
- W4306146735 cites W4226143945 @default.
- W4306146735 cites W4254732828 @default.
- W4306146735 doi "https://doi.org/10.1155/2022/6561047" @default.
- W4306146735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36275636" @default.
- W4306146735 hasPublicationYear "2022" @default.
- W4306146735 type Work @default.
- W4306146735 citedByCount "1" @default.
- W4306146735 countsByYear W43061467352023 @default.
- W4306146735 crossrefType "journal-article" @default.
- W4306146735 hasAuthorship W4306146735A5006221281 @default.
- W4306146735 hasAuthorship W4306146735A5040444759 @default.
- W4306146735 hasAuthorship W4306146735A5045226074 @default.
- W4306146735 hasAuthorship W4306146735A5053766095 @default.
- W4306146735 hasAuthorship W4306146735A5053911309 @default.
- W4306146735 hasAuthorship W4306146735A5055537356 @default.
- W4306146735 hasBestOaLocation W43061467351 @default.
- W4306146735 hasConcept C104317684 @default.
- W4306146735 hasConcept C118131993 @default.
- W4306146735 hasConcept C121608353 @default.
- W4306146735 hasConcept C126322002 @default.
- W4306146735 hasConcept C127561419 @default.
- W4306146735 hasConcept C145059251 @default.
- W4306146735 hasConcept C173396325 @default.
- W4306146735 hasConcept C502942594 @default.
- W4306146735 hasConcept C526805850 @default.
- W4306146735 hasConcept C54355233 @default.
- W4306146735 hasConcept C62112901 @default.
- W4306146735 hasConcept C62478195 @default.
- W4306146735 hasConcept C71924100 @default.
- W4306146735 hasConcept C81885089 @default.
- W4306146735 hasConcept C85265743 @default.
- W4306146735 hasConcept C86803240 @default.
- W4306146735 hasConcept C95444343 @default.
- W4306146735 hasConceptScore W4306146735C104317684 @default.
- W4306146735 hasConceptScore W4306146735C118131993 @default.
- W4306146735 hasConceptScore W4306146735C121608353 @default.
- W4306146735 hasConceptScore W4306146735C126322002 @default.
- W4306146735 hasConceptScore W4306146735C127561419 @default.
- W4306146735 hasConceptScore W4306146735C145059251 @default.
- W4306146735 hasConceptScore W4306146735C173396325 @default.
- W4306146735 hasConceptScore W4306146735C502942594 @default.
- W4306146735 hasConceptScore W4306146735C526805850 @default.
- W4306146735 hasConceptScore W4306146735C54355233 @default.
- W4306146735 hasConceptScore W4306146735C62112901 @default.
- W4306146735 hasConceptScore W4306146735C62478195 @default.
- W4306146735 hasConceptScore W4306146735C71924100 @default.
- W4306146735 hasConceptScore W4306146735C81885089 @default.
- W4306146735 hasConceptScore W4306146735C85265743 @default.
- W4306146735 hasConceptScore W4306146735C86803240 @default.
- W4306146735 hasConceptScore W4306146735C95444343 @default.
- W4306146735 hasLocation W43061467351 @default.
- W4306146735 hasLocation W43061467352 @default.
- W4306146735 hasLocation W43061467353 @default.