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- W4306155448 abstract "Venous thromboembolism is a major hospital acquired complication in the pediatric population over the last two-decades, with a 130% increase in the past decade. Direct oral anticoagulants (DOACs) are a newer class of anticoagulant medication for the treatment and prophylaxis of VTEs that provide the primary advantages of an oral route of administration without a requirement to adjust dosing to achieve a therapeutic level. It is anticipated that these medications will quickly replace parenteral anticoagulants and clinicians should familiarize themselves with DOACs. In this article, we provide an overview of the pharmacological properties of DOACs, with a specific focus on rivaroxaban and dabigatran, which have been approved for use in pediatric patients. Each drug's characteristics are discussed along with data from their respective clinical trials." @default.
- W4306155448 created "2022-10-14" @default.
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- W4306155448 date "2022-10-13" @default.
- W4306155448 modified "2023-09-30" @default.
- W4306155448 title "Direct oral anticoagulants in pediatric venous thromboembolism: Review of approved products rivaroxaban and dabigatran" @default.
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- W4306155448 doi "https://doi.org/10.3389/fped.2022.1005098" @default.
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