Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306156658> ?p ?o ?g. }
- W4306156658 endingPage "548" @default.
- W4306156658 startingPage "537" @default.
- W4306156658 abstract "Obesity has increased worldwide recently and represents a major global health challenge. This review focuses on the obesity-associated cellular senescence in various organs and the role of these senescent cells (SnCs) in driving complications associated with obesity. Also, the ability to target SnCs pharmacologically with drugs termed senotherapeutics as a therapy for these complications is discussed.Several studies have shown a positive correlation between obesity and SnC burden in organs such as adipose tissue, liver, and pancreatic-β-cells. These SnCs produce several secretory factors which affect other cells and tissues in a paracrine manner resulting in organ dysfunction. The accumulation of SnCs in adipocytes affects their lipid storage and impairs adipogenesis. The inflammatory senescence-associated secretory phenotype (SASP) of SnCs downregulates the antioxidant capacity and mitochondrial function in tissues. Senescent hepatocytes cannot oxidize fatty acids, which leads to lipid deposition and senescence in β-cells decrease function. These and other adverse effects of SnCs contribute to insulin resistance and type-2 diabetes. The reduction in the SnC burden genetically or pharmacologically improves the complications associated with obesity. The accumulation of SnCs with age and disease accelerates aging. Obesity is a key driver of SnC accumulation, and the complications associated with obesity can be controlled by reducing the SnC burden. Thus, senotherapeutic drugs have the potential to be an effective therapeutic option." @default.
- W4306156658 created "2022-10-14" @default.
- W4306156658 creator A5027851545 @default.
- W4306156658 creator A5040467127 @default.
- W4306156658 creator A5043039694 @default.
- W4306156658 creator A5050075073 @default.
- W4306156658 creator A5055230524 @default.
- W4306156658 creator A5081338125 @default.
- W4306156658 date "2022-10-14" @default.
- W4306156658 modified "2023-10-16" @default.
- W4306156658 title "Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target" @default.
- W4306156658 cites W1494611500 @default.
- W4306156658 cites W1513674275 @default.
- W4306156658 cites W1745433757 @default.
- W4306156658 cites W1800944583 @default.
- W4306156658 cites W1903840039 @default.
- W4306156658 cites W1910950086 @default.
- W4306156658 cites W1932046626 @default.
- W4306156658 cites W1964041100 @default.
- W4306156658 cites W1970891016 @default.
- W4306156658 cites W1978454776 @default.
- W4306156658 cites W1989823340 @default.
- W4306156658 cites W1993959456 @default.
- W4306156658 cites W1995205742 @default.
- W4306156658 cites W2000312101 @default.
- W4306156658 cites W2001649002 @default.
- W4306156658 cites W2008704214 @default.
- W4306156658 cites W2010957046 @default.
- W4306156658 cites W2014998225 @default.
- W4306156658 cites W2018902473 @default.
- W4306156658 cites W2019276374 @default.
- W4306156658 cites W2025152562 @default.
- W4306156658 cites W2026890342 @default.
- W4306156658 cites W2028658648 @default.
- W4306156658 cites W2041544510 @default.
- W4306156658 cites W2044341880 @default.
- W4306156658 cites W2053173773 @default.
- W4306156658 cites W2059699638 @default.
- W4306156658 cites W2061182191 @default.
- W4306156658 cites W2061619522 @default.
- W4306156658 cites W2064871936 @default.
- W4306156658 cites W2069971581 @default.
- W4306156658 cites W2070910260 @default.
- W4306156658 cites W2074871320 @default.
- W4306156658 cites W2075152260 @default.
- W4306156658 cites W2077283403 @default.
- W4306156658 cites W2088940658 @default.
- W4306156658 cites W2099635702 @default.
- W4306156658 cites W2100633524 @default.
- W4306156658 cites W2108975920 @default.
- W4306156658 cites W2109371472 @default.
- W4306156658 cites W2109579177 @default.
- W4306156658 cites W2113544353 @default.
- W4306156658 cites W2114416343 @default.
- W4306156658 cites W2115852450 @default.
- W4306156658 cites W2116672880 @default.
- W4306156658 cites W2117473844 @default.
- W4306156658 cites W2123668936 @default.
- W4306156658 cites W2131078803 @default.
- W4306156658 cites W2135766812 @default.
- W4306156658 cites W2137067830 @default.
- W4306156658 cites W2140173726 @default.
- W4306156658 cites W2141731752 @default.
- W4306156658 cites W2145690342 @default.
- W4306156658 cites W2146336603 @default.
- W4306156658 cites W2152602162 @default.
- W4306156658 cites W2153903661 @default.
- W4306156658 cites W2160279897 @default.
- W4306156658 cites W2162229546 @default.
- W4306156658 cites W2182320529 @default.
- W4306156658 cites W2191745121 @default.
- W4306156658 cites W2194368038 @default.
- W4306156658 cites W2266900518 @default.
- W4306156658 cites W2313646508 @default.
- W4306156658 cites W2342055991 @default.
- W4306156658 cites W2507143304 @default.
- W4306156658 cites W2510339450 @default.
- W4306156658 cites W2518194013 @default.
- W4306156658 cites W2540036007 @default.
- W4306156658 cites W2548313353 @default.
- W4306156658 cites W2596449235 @default.
- W4306156658 cites W2624997514 @default.
- W4306156658 cites W2735754703 @default.
- W4306156658 cites W2742876579 @default.
- W4306156658 cites W2750464235 @default.
- W4306156658 cites W2789524740 @default.
- W4306156658 cites W2792246690 @default.
- W4306156658 cites W2793688865 @default.
- W4306156658 cites W2804734969 @default.
- W4306156658 cites W2860743873 @default.
- W4306156658 cites W2884285551 @default.
- W4306156658 cites W2886159477 @default.
- W4306156658 cites W2886368654 @default.
- W4306156658 cites W2915166661 @default.
- W4306156658 cites W2921485622 @default.
- W4306156658 cites W2946555371 @default.
- W4306156658 cites W2947927825 @default.
- W4306156658 cites W2952357134 @default.