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• W4306165720 abstract "The greatest significant influence on human life span and health is inevitable ageing. One of the distinguishing characteristics of ageing is the gradual decrease of muscle mass and physical function. There has been growing evidence that tocotrienol can guard against age-associated chronic diseases and metabolic disorders. This study aimed to elucidate the effects of tocotrienol-rich fraction (TRF) on muscle metabolomes and metabolic pathways in ageing Sprague Dawley (SD) rats. Three months, 9 months, and 21 months old male SD rats were divided into control and treated groups with 10 rats per group. Rats in control and treated groups were given 60 mg/kg body weight/day of palm olein and 60 mg/kg body weight/day of TRF, respectively, via oral gavage for 3 months. Muscle performance was assessed at 0 and 3 months of treatment by measuring muscle strength and function. Our results showed that TRF treatment caused a significant increase in the swimming time of the young rats. Comparison in the control groups showed that metabolites involved in lipid metabolisms such as L-palmitoyl carnitine and decanoyl carnitine were increased in ageing. In contrast, several metabolites, such as 3-phosphoglyceric acid, aspartic acid and aspartyl phenylalanine were decreased. These findings indicated that muscle metabolomes involved in lipid metabolism were upregulated in aged rats. In contrast, the metabolites involved in energy and amino acid metabolism were significantly downregulated. Comparison in the TRF-supplemented groups showed an upregulation of metabolites involved in energy and amino acid metabolism. Metabolites such as N6-methyl adenosine, spermine, phenylalanine, tryptophan, aspartic acid, histidine, and N-acetyl neuraminic acid were up-regulated, indicating promotion of amino acid synthesis and muscle regeneration. Energy metabolism was also improved in adult and old rats with TRF supplementation as indicated by the upregulation of nicotinamide adenine dinucleotide and glycerol 3-phosphate compared to the control group. In conclusion, the mechanism underlying the changes in skeletal muscle mass and functions in ageing was related to carbohydrate, lipid and amino acid metabolism. Tocotrienol supplementation showed beneficial effects in alleviating energy and amino acid synthesis that may promote the regeneration and renewal of skeletal muscle in ageing rats." @default.
• W4306165720 created "2022-10-14" @default.
• W4306165720 creator A5007761747 @default.
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• W4306165720 date "2022-10-14" @default.
• W4306165720 modified "2023-10-01" @default.
• W4306165720 title "Untargeted muscle tissue metabolites profiling in young, adult, and old rats supplemented with tocotrienol-rich fraction" @default.
• W4306165720 cites W1534340623 @default.
• W4306165720 cites W1737180198 @default.
• W4306165720 cites W1900956557 @default.
• W4306165720 cites W1911542743 @default.
• W4306165720 cites W1919082278 @default.
• W4306165720 cites W1932780354 @default.
• W4306165720 cites W1967249629 @default.
• W4306165720 cites W1970060526 @default.
• W4306165720 cites W1975742849 @default.
• W4306165720 cites W1976195583 @default.
• W4306165720 cites W1977772882 @default.
• W4306165720 cites W1980066430 @default.
• W4306165720 cites W1982152979 @default.
• W4306165720 cites W1986760556 @default.
• W4306165720 cites W1992107155 @default.
• W4306165720 cites W1996503400 @default.
• W4306165720 cites W2019744246 @default.
• W4306165720 cites W2021664757 @default.
• W4306165720 cites W2028629615 @default.
• W4306165720 cites W2030760725 @default.
• W4306165720 cites W2039663806 @default.
• W4306165720 cites W2044183703 @default.
• W4306165720 cites W2049942632 @default.
• W4306165720 cites W2055969761 @default.
• W4306165720 cites W2058793228 @default.
• W4306165720 cites W2060090988 @default.
• W4306165720 cites W2067600563 @default.
• W4306165720 cites W2079529928 @default.
• W4306165720 cites W2081067390 @default.
• W4306165720 cites W2090442368 @default.
• W4306165720 cites W2099281324 @default.
• W4306165720 cites W2099535442 @default.
• W4306165720 cites W2102902846 @default.
• W4306165720 cites W2104007452 @default.
• W4306165720 cites W2110790504 @default.
• W4306165720 cites W2110957605 @default.
• W4306165720 cites W2116264302 @default.
• W4306165720 cites W2124911115 @default.
• W4306165720 cites W2124943768 @default.
• W4306165720 cites W2126525177 @default.
• W4306165720 cites W2127835340 @default.
• W4306165720 cites W2148197808 @default.
• W4306165720 cites W2150059080 @default.
• W4306165720 cites W2157511458 @default.
• W4306165720 cites W2159914115 @default.
• W4306165720 cites W2161284887 @default.
• W4306165720 cites W2169732076 @default.
• W4306165720 cites W2182291606 @default.
• W4306165720 cites W2184068143 @default.
• W4306165720 cites W2214973932 @default.
• W4306165720 cites W2215653021 @default.
• W4306165720 cites W2229146261 @default.
• W4306165720 cites W2269817058 @default.
• W4306165720 cites W2287626946 @default.
• W4306165720 cites W2295505321 @default.
• W4306165720 cites W2325165656 @default.
• W4306165720 cites W2503524587 @default.
• W4306165720 cites W2520222164 @default.
• W4306165720 cites W2566070181 @default.
• W4306165720 cites W2607049035 @default.
• W4306165720 cites W2616553828 @default.
• W4306165720 cites W2735054066 @default.
• W4306165720 cites W2756637506 @default.
• W4306165720 cites W2761025268 @default.
• W4306165720 cites W2788248012 @default.
• W4306165720 cites W2855717724 @default.
• W4306165720 cites W2898783426 @default.
• W4306165720 cites W2899083341 @default.
• W4306165720 cites W2910116534 @default.
• W4306165720 cites W2912064295 @default.
• W4306165720 cites W2919001325 @default.
• W4306165720 cites W2968995439 @default.
• W4306165720 cites W2981093242 @default.
• W4306165720 cites W2982050566 @default.
• W4306165720 cites W2985991833 @default.
• W4306165720 cites W2992958546 @default.
• W4306165720 cites W2997588202 @default.
• W4306165720 cites W3016730677 @default.
• W4306165720 cites W3016938917 @default.
• W4306165720 cites W3034144541 @default.
• W4306165720 cites W3083126535 @default.
• W4306165720 cites W3106590902 @default.
• W4306165720 cites W3157975861 @default.
• W4306165720 cites W3175747678 @default.
• W4306165720 cites W3180005471 @default.
• W4306165720 cites W3191375567 @default.
• W4306165720 cites W3211219087 @default.
• W4306165720 cites W7969656 @default.

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