FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306173651> ?p ?o ?g. }

• W4306173651 endingPage "2494" @default.
• W4306173651 startingPage "2490" @default.
• W4306173651 abstract "Estrogen receptor alpha (ERα) is a ligand-responsive transcription factor critical for sex determination and development. Recent reports challenge the canonical view of ERα function by suggesting an activity beyond binding dsDNA at estrogen-responsive promotor elements: association with RNAs in vivo. Whether these interactions are direct or indirect remains unknown, which limits the ability to understand the extent, specificity, and biological role of ERα-RNA binding. Here we demonstrate that an extended DNA-binding domain of ERα directly binds a wide range of RNAs in vitro with structural specificity. ERα binds RNAs that adopt a range of hairpin-derived structures independent of sequence, while interacting poorly with single- and double-stranded RNA. RNA affinities are only 4-fold weaker than consensus dsDNA and significantly tighter than nonconsensus dsDNA sequences. Moreover, RNA binding is competitive with DNA binding. Together, these data show that ERα utilizes an extended DNA-binding domain to achieve a high-affinity/low-specificity mode for interacting with RNA." @default.
• W4306173651 created "2022-10-14" @default.
• W4306173651 creator A5004642468 @default.
• W4306173651 creator A5015379463 @default.
• W4306173651 creator A5031343617 @default.
• W4306173651 creator A5047811743 @default.
• W4306173651 date "2022-10-14" @default.
• W4306173651 modified "2023-10-03" @default.
• W4306173651 title "An Extended DNA Binding Domain of the Estrogen Receptor Alpha Directly Interacts with RNAs <i>in Vitro</i>" @default.
• W4306173651 cites W1739743960 @default.
• W4306173651 cites W1967538502 @default.
• W4306173651 cites W1994248538 @default.
• W4306173651 cites W1997681444 @default.
• W4306173651 cites W2012206989 @default.
• W4306173651 cites W2017312207 @default.
• W4306173651 cites W2023077979 @default.
• W4306173651 cites W2036766833 @default.
• W4306173651 cites W2043317822 @default.
• W4306173651 cites W2046792302 @default.
• W4306173651 cites W2058768824 @default.
• W4306173651 cites W2071271349 @default.
• W4306173651 cites W2093531960 @default.
• W4306173651 cites W2109941680 @default.
• W4306173651 cites W2112444654 @default.
• W4306173651 cites W2113748824 @default.
• W4306173651 cites W2132185105 @default.
• W4306173651 cites W2133141667 @default.
• W4306173651 cites W2133876293 @default.
• W4306173651 cites W2170728568 @default.
• W4306173651 cites W2170796746 @default.
• W4306173651 cites W2274023561 @default.
• W4306173651 cites W2400250419 @default.
• W4306173651 cites W2560132745 @default.
• W4306173651 cites W2575891648 @default.
• W4306173651 cites W2618657542 @default.
• W4306173651 cites W2757523607 @default.
• W4306173651 cites W2804262814 @default.
• W4306173651 cites W2885448192 @default.
• W4306173651 cites W2947425925 @default.
• W4306173651 cites W2973172290 @default.
• W4306173651 cites W2998594744 @default.
• W4306173651 cites W3016077210 @default.
• W4306173651 cites W3200715289 @default.
• W4306173651 cites W2024152657 @default.
• W4306173651 doi "https://doi.org/10.1021/acs.biochem.2c00536" @default.
• W4306173651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36239332" @default.
• W4306173651 hasPublicationYear "2022" @default.
• W4306173651 type Work @default.
• W4306173651 citedByCount "9" @default.
• W4306173651 countsByYear W43061736512022 @default.
• W4306173651 countsByYear W43061736512023 @default.
• W4306173651 crossrefType "journal-article" @default.
• W4306173651 hasAuthorship W4306173651A5004642468 @default.
• W4306173651 hasAuthorship W4306173651A5015379463 @default.
• W4306173651 hasAuthorship W4306173651A5031343617 @default.
• W4306173651 hasAuthorship W4306173651A5047811743 @default.
• W4306173651 hasBestOaLocation W43061736511 @default.
• W4306173651 hasConcept C104317684 @default.
• W4306173651 hasConcept C107824862 @default.
• W4306173651 hasConcept C121608353 @default.
• W4306173651 hasConcept C138885662 @default.
• W4306173651 hasConcept C153911025 @default.
• W4306173651 hasConcept C172313692 @default.
• W4306173651 hasConcept C179926584 @default.
• W4306173651 hasConcept C185592680 @default.
• W4306173651 hasConcept C25166345 @default.
• W4306173651 hasConcept C41895202 @default.
• W4306173651 hasConcept C530470458 @default.
• W4306173651 hasConcept C54355233 @default.
• W4306173651 hasConcept C552990157 @default.
• W4306173651 hasConcept C67705224 @default.
• W4306173651 hasConcept C70721500 @default.
• W4306173651 hasConcept C84606932 @default.
• W4306173651 hasConcept C86803240 @default.
• W4306173651 hasConcept C95444343 @default.
• W4306173651 hasConceptScore W4306173651C104317684 @default.
• W4306173651 hasConceptScore W4306173651C107824862 @default.
• W4306173651 hasConceptScore W4306173651C121608353 @default.
• W4306173651 hasConceptScore W4306173651C138885662 @default.
• W4306173651 hasConceptScore W4306173651C153911025 @default.
• W4306173651 hasConceptScore W4306173651C172313692 @default.
• W4306173651 hasConceptScore W4306173651C179926584 @default.
• W4306173651 hasConceptScore W4306173651C185592680 @default.
• W4306173651 hasConceptScore W4306173651C25166345 @default.
• W4306173651 hasConceptScore W4306173651C41895202 @default.
• W4306173651 hasConceptScore W4306173651C530470458 @default.
• W4306173651 hasConceptScore W4306173651C54355233 @default.
• W4306173651 hasConceptScore W4306173651C552990157 @default.
• W4306173651 hasConceptScore W4306173651C67705224 @default.
• W4306173651 hasConceptScore W4306173651C70721500 @default.
• W4306173651 hasConceptScore W4306173651C84606932 @default.
• W4306173651 hasConceptScore W4306173651C86803240 @default.
• W4306173651 hasConceptScore W4306173651C95444343 @default.
• W4306173651 hasFunder F4320306076 @default.
• W4306173651 hasFunder F4320332161 @default.
• W4306173651 hasIssue "22" @default.
• W4306173651 hasLocation W43061736511 @default.
• W4306173651 hasLocation W43061736512 @default.

• next