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- W4306173709 endingPage "1215" @default.
- W4306173709 startingPage "1203" @default.
- W4306173709 abstract "With the recent description of the molecular and cellular characteristics that enable acquisition of both core and new hallmarks of cancer, the consequences of transcription factor dysregulation in the hallmarks scheme has become increasingly evident. Dysregulation or mutation of transcription factors has long been recognized in the development of cancer where alterations in these key regulatory molecules can result in aberrant gene expression and consequential blockade of normal cellular differentiation. Here, we provide an up-to-date review of involvement of dysregulated transcription factor networks with the most recently reported cancer hallmarks and enabling characteristic properties. We present some illustrative examples of the impact of dysregulated transcription factors, specifically focusing on the characteristics of phenotypic plasticity, non-mutational epigenetic reprogramming, polymorphic microbiomes, and senescence. We also discuss how new insights into transcription factor dysregulation in cancer is contributing to addressing current therapeutic challenges." @default.
- W4306173709 created "2022-10-14" @default.
- W4306173709 creator A5013314085 @default.
- W4306173709 creator A5018614325 @default.
- W4306173709 creator A5061230941 @default.
- W4306173709 date "2022-11-01" @default.
- W4306173709 modified "2023-10-18" @default.
- W4306173709 title "The role of transcription factors in the acquisition of the four latest proposed hallmarks of cancer and corresponding enabling characteristics" @default.
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