Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306173786> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4306173786 endingPage "52" @default.
- W4306173786 startingPage "45" @default.
- W4306173786 abstract "Background Patients with heart failure (HF) experience frequent alterations of serum potassium. Despite the high risk of events associated with hypokalemia, hyperkalemia is feared by clinicians and often leads to interruption or discontinuation of renin–angiotensin–aldosterone system inhibitors. Data on serum potassium of patients treated with different doses of renin–angiotensin–aldosterone system inhibitors are scarce. Methods and Results The effects of high-dose vs low-dose losartan on clinical outcomes in patients with heart failure (HEAAL) trial randomized 3834 patients with HFrEF intolerant to angiotensin-converting enzyme inhibitors to losartan 150 mg/d (high dose) vs 50 mg/d (low dose). We studied the associations of serum potassium (baseline and time updated) with study outcomes and the effect of the randomized treatment on serum potassium. Patients with higher baseline potassium were older, had diabetes, poorer renal function, and used mineralocorticoid receptor antagonists more frequently. In time-updated models, hyperkalemia (>5.0 or ≥5.5 mmol/L) was not associated with cardiovascular death or the composite of cardiovascular death or HF hospitalization. Hypokalemia (serum potassium of ≤3.5 mmol/L, in particular) was associated with a higher risk of the composite of cardiovascular death or HF hospitalization (hazard ratio [HR] 1.58, 95% confidence interval [CI] 1.19–2.08), all-cause death (HR 1.68, 95% CI 1.26–2.24), and sudden cardiac death or resuscitated cardiac arrest (HR 1.74, 95% CI 1.11–2.73). High-dose losartan decreased the risk of hypokalemia (HR 0.77, 95% CI 0.63–0.92) and increased the risk of hyperkalemia (HR 1.21, 95% CI 1.05–1.39). High-dose losartan decreased the composite of cardiovascular death or HF hospitalizations consistently across the full spectrum of serum potassium at baseline (interaction P = .85). Conclusions : In patients with HF with reduced ejection fraction intolerant to angiotensin-converting enzyme inhibitors and treated with either high- or low-dose losartan, incident hypokalemia had a stronger association with poor outcomes than incident hyperkalemia. High-dose losartan reduced the incidence of hypokalemia, and its benefits were maintained across the full spectrum of serum potassium." @default.
- W4306173786 created "2022-10-14" @default.
- W4306173786 creator A5001704230 @default.
- W4306173786 creator A5036821495 @default.
- W4306173786 creator A5051961415 @default.
- W4306173786 creator A5060658296 @default.
- W4306173786 creator A5081791142 @default.
- W4306173786 date "2023-01-01" @default.
- W4306173786 modified "2023-10-07" @default.
- W4306173786 title "High- Versus Low-dose Losartan and Serum Potassium: An Analysis From HEAAL" @default.
- W4306173786 cites W2105138814 @default.
- W4306173786 cites W2113698123 @default.
- W4306173786 cites W2129711762 @default.
- W4306173786 cites W2165407521 @default.
- W4306173786 cites W2553961474 @default.
- W4306173786 cites W2763547670 @default.
- W4306173786 cites W2800434402 @default.
- W4306173786 cites W3014145124 @default.
- W4306173786 cites W3032629802 @default.
- W4306173786 cites W3078936950 @default.
- W4306173786 cites W3130684163 @default.
- W4306173786 cites W4281938364 @default.
- W4306173786 doi "https://doi.org/10.1016/j.cardfail.2022.09.008" @default.
- W4306173786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36244652" @default.
- W4306173786 hasPublicationYear "2023" @default.
- W4306173786 type Work @default.
- W4306173786 citedByCount "0" @default.
- W4306173786 crossrefType "journal-article" @default.
- W4306173786 hasAuthorship W4306173786A5001704230 @default.
- W4306173786 hasAuthorship W4306173786A5036821495 @default.
- W4306173786 hasAuthorship W4306173786A5051961415 @default.
- W4306173786 hasAuthorship W4306173786A5060658296 @default.
- W4306173786 hasAuthorship W4306173786A5081791142 @default.
- W4306173786 hasBestOaLocation W43061737862 @default.
- W4306173786 hasConcept C126322002 @default.
- W4306173786 hasConcept C126894567 @default.
- W4306173786 hasConcept C134018914 @default.
- W4306173786 hasConcept C164705383 @default.
- W4306173786 hasConcept C198710026 @default.
- W4306173786 hasConcept C207103383 @default.
- W4306173786 hasConcept C2776379505 @default.
- W4306173786 hasConcept C2778198053 @default.
- W4306173786 hasConcept C2778242168 @default.
- W4306173786 hasConcept C2778525890 @default.
- W4306173786 hasConcept C2778715236 @default.
- W4306173786 hasConcept C2780243291 @default.
- W4306173786 hasConcept C2780288358 @default.
- W4306173786 hasConcept C2909209853 @default.
- W4306173786 hasConcept C44249647 @default.
- W4306173786 hasConcept C71924100 @default.
- W4306173786 hasConcept C84393581 @default.
- W4306173786 hasConceptScore W4306173786C126322002 @default.
- W4306173786 hasConceptScore W4306173786C126894567 @default.
- W4306173786 hasConceptScore W4306173786C134018914 @default.
- W4306173786 hasConceptScore W4306173786C164705383 @default.
- W4306173786 hasConceptScore W4306173786C198710026 @default.
- W4306173786 hasConceptScore W4306173786C207103383 @default.
- W4306173786 hasConceptScore W4306173786C2776379505 @default.
- W4306173786 hasConceptScore W4306173786C2778198053 @default.
- W4306173786 hasConceptScore W4306173786C2778242168 @default.
- W4306173786 hasConceptScore W4306173786C2778525890 @default.
- W4306173786 hasConceptScore W4306173786C2778715236 @default.
- W4306173786 hasConceptScore W4306173786C2780243291 @default.
- W4306173786 hasConceptScore W4306173786C2780288358 @default.
- W4306173786 hasConceptScore W4306173786C2909209853 @default.
- W4306173786 hasConceptScore W4306173786C44249647 @default.
- W4306173786 hasConceptScore W4306173786C71924100 @default.
- W4306173786 hasConceptScore W4306173786C84393581 @default.
- W4306173786 hasIssue "1" @default.
- W4306173786 hasLocation W43061737861 @default.
- W4306173786 hasLocation W43061737862 @default.
- W4306173786 hasLocation W43061737863 @default.
- W4306173786 hasLocation W43061737864 @default.
- W4306173786 hasOpenAccess W4306173786 @default.
- W4306173786 hasPrimaryLocation W43061737861 @default.
- W4306173786 hasRelatedWork W174527792 @default.
- W4306173786 hasRelatedWork W1969123217 @default.
- W4306173786 hasRelatedWork W2016647631 @default.
- W4306173786 hasRelatedWork W2047608102 @default.
- W4306173786 hasRelatedWork W2077998387 @default.
- W4306173786 hasRelatedWork W2126797993 @default.
- W4306173786 hasRelatedWork W2154337708 @default.
- W4306173786 hasRelatedWork W2312942238 @default.
- W4306173786 hasRelatedWork W2384071926 @default.
- W4306173786 hasRelatedWork W4306173786 @default.
- W4306173786 hasVolume "29" @default.
- W4306173786 isParatext "false" @default.
- W4306173786 isRetracted "false" @default.
- W4306173786 workType "article" @default.