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- W4306173813 abstract "Cardiac patch, a scaffold layered on the surface of the heart that can provide mechanical and regeneration support for damaged myocardium, has provided a promising solution to treat severe myocardial infarction (MI). In this work, a fibrin based cardiac patch loaded with neuregulin-1 (NRG-1) is developed to attach locally to the infract area of heart. The composite patch exhibited good biocompatibility and promoted cardiomyocyte proliferation in vitro via NRG-1/ErbB signaling. Moreover, implantation of this patch to the infracted border zone reduced cell apoptosis, promoted angiogenesis and inhibited fibrosis, which reduced infraction size and improved cardiac function consequently. Thus, the combination of natural biomaterial fibrin and bioactive factor NRG-1 might have a promising potential for clinical application of MI treatment." @default.
- W4306173813 created "2022-10-14" @default.
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- W4306173813 date "2022-12-01" @default.
- W4306173813 modified "2023-10-16" @default.
- W4306173813 title "Fibrin-based cardiac patch containing neuregulin-1 for heart repair after myocardial infarction" @default.
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- W4306173813 doi "https://doi.org/10.1016/j.colsurfb.2022.112936" @default.
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