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• W4306173854 endingPage "1431" @default.
• W4306173854 startingPage "1418" @default.
• W4306173854 abstract "In recent years, the possibility to noninvasively interact with the human brain has led to unprecedented diagnostic and therapeutic opportunities. However, the vast majority of approved interventions and approaches still rely on anatomical landmarks and rarely on the individual structure of networks in the brain, drastically reducing the potential efficacy of neuromodulation.Here we implemented a target search algorithm leveraging on mathematical tools from Network Control Theory (NCT) and whole brain connectomics analysis. By means of computational simulations, we aimed to identify the optimal stimulation target(s)- at the individual brain level- capable of reaching maximal engagement of the stimulated networks' nodes.At the model level, in silico predictions suggest that stimulation of NCT-derived cerebral sites might induce significantly higher network engagement, compared to traditionally employed neuromodulation sites, demonstrating NCT to be a useful tool in guiding brain stimulation. Indeed, NCT allows us to computationally model different stimulation scenarios tailored on the individual structural connectivity profiles and initial brain states.The use of NCT to computationally predict TMS pulse propagation suggests that individualized targeting is crucial for more successful network engagement. Future studies will be needed to verify such prediction in real stimulation scenarios." @default.
• W4306173854 created "2022-10-14" @default.
• W4306173854 creator A5009786305 @default.
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• W4306173854 creator A5038976962 @default.
• W4306173854 creator A5087175282 @default.
• W4306173854 date "2022-11-01" @default.
• W4306173854 modified "2023-10-18" @default.
• W4306173854 title "Maximizing brain networks engagement via individualized connectome-wide target search" @default.
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• W4306173854 doi "https://doi.org/10.1016/j.brs.2022.09.011" @default.
• W4306173854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36252908" @default.

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