FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306173904> ?p ?o ?g. }

• W4306173904 endingPage "114812" @default.
• W4306173904 startingPage "114812" @default.
• W4306173904 abstract "The activation of inflammasome leads to secretion of inflammatory factors and cell pyroptosis that are critical in the pathogenesis of various chronic and acute inflammatory diseases. Recruitment and activation of caspase-1 is a marker of inflammasome activation. However, there is still lack of real-time and efficient methods to detect the activation of inflammasome, especially in vivo. Herein, we developed two activatable caspase-1-responsive fluorescence biosensors, WEHD-HCy and YVAD-HCy, to specifically monitor the activation of inflammasome in vivo. Our in vitro study demonstrated that WEHD-HCy and YVAD-HCy can sensitively and specifically respond to caspase-1 activation. Moreover, these biosensors can efficiency and specifically activated in the common inflammatory disease model, including inflammatory bowel disease, Salmonella infection, and acute arthritis. In particular, WEHD-HCy is more advantageous than YVAD-HCy to specifically image of caspase-1 activity both in vitro and in vivo. These caspase-1-responsive fluorescence biosensors provide an efficient, rapid, and in situ tool for monitoring inflammasome activation, and have the potential to be suitable for clinical diagnosis of various inflammatory diseases associated with inflammasome activation." @default.
• W4306173904 created "2022-10-14" @default.
• W4306173904 creator A5023814422 @default.
• W4306173904 creator A5035298412 @default.
• W4306173904 creator A5040793026 @default.
• W4306173904 creator A5051859353 @default.
• W4306173904 creator A5056674934 @default.
• W4306173904 creator A5064712935 @default.
• W4306173904 date "2023-01-01" @default.
• W4306173904 modified "2023-10-17" @default.
• W4306173904 title "Caspase-1-responsive fluorescence biosensors for monitoring endogenous inflammasome activation" @default.
• W4306173904 cites W1864325817 @default.
• W4306173904 cites W1906326080 @default.
• W4306173904 cites W1963548438 @default.
• W4306173904 cites W1987535382 @default.
• W4306173904 cites W2150221822 @default.
• W4306173904 cites W2201316930 @default.
• W4306173904 cites W2295538865 @default.
• W4306173904 cites W2299572864 @default.
• W4306173904 cites W2325129919 @default.
• W4306173904 cites W2467376564 @default.
• W4306173904 cites W2591909929 @default.
• W4306173904 cites W2783718636 @default.
• W4306173904 cites W2791974746 @default.
• W4306173904 cites W2793295342 @default.
• W4306173904 cites W2890670389 @default.
• W4306173904 cites W2894692315 @default.
• W4306173904 cites W2899131445 @default.
• W4306173904 cites W2946216397 @default.
• W4306173904 cites W2966383526 @default.
• W4306173904 cites W2975907298 @default.
• W4306173904 cites W2976957583 @default.
• W4306173904 cites W2980258968 @default.
• W4306173904 cites W2980610095 @default.
• W4306173904 cites W2991821439 @default.
• W4306173904 cites W2999767968 @default.
• W4306173904 cites W3010003232 @default.
• W4306173904 cites W3033829306 @default.
• W4306173904 cites W3065584339 @default.
• W4306173904 cites W3088652394 @default.
• W4306173904 cites W3127599861 @default.
• W4306173904 cites W3134632803 @default.
• W4306173904 cites W3139367533 @default.
• W4306173904 cites W3140812858 @default.
• W4306173904 cites W3161014063 @default.
• W4306173904 cites W3173230980 @default.
• W4306173904 cites W3200159992 @default.
• W4306173904 cites W3204413590 @default.
• W4306173904 cites W4211064536 @default.
• W4306173904 cites W602046433 @default.
• W4306173904 doi "https://doi.org/10.1016/j.bios.2022.114812" @default.
• W4306173904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36272346" @default.
• W4306173904 hasPublicationYear "2023" @default.
• W4306173904 type Work @default.
• W4306173904 citedByCount "4" @default.
• W4306173904 countsByYear W43061739042023 @default.
• W4306173904 crossrefType "journal-article" @default.
• W4306173904 hasAuthorship W4306173904A5023814422 @default.
• W4306173904 hasAuthorship W4306173904A5035298412 @default.
• W4306173904 hasAuthorship W4306173904A5040793026 @default.
• W4306173904 hasAuthorship W4306173904A5051859353 @default.
• W4306173904 hasAuthorship W4306173904A5056674934 @default.
• W4306173904 hasAuthorship W4306173904A5064712935 @default.
• W4306173904 hasConcept C139964883 @default.
• W4306173904 hasConcept C150903083 @default.
• W4306173904 hasConcept C17172800 @default.
• W4306173904 hasConcept C185592680 @default.
• W4306173904 hasConcept C187831198 @default.
• W4306173904 hasConcept C190283241 @default.
• W4306173904 hasConcept C202751555 @default.
• W4306173904 hasConcept C203014093 @default.
• W4306173904 hasConcept C207001950 @default.
• W4306173904 hasConcept C2776914184 @default.
• W4306173904 hasConcept C2777209026 @default.
• W4306173904 hasConcept C31573885 @default.
• W4306173904 hasConcept C55493867 @default.
• W4306173904 hasConcept C86803240 @default.
• W4306173904 hasConcept C95444343 @default.
• W4306173904 hasConcept C98424977 @default.
• W4306173904 hasConceptScore W4306173904C139964883 @default.
• W4306173904 hasConceptScore W4306173904C150903083 @default.
• W4306173904 hasConceptScore W4306173904C17172800 @default.
• W4306173904 hasConceptScore W4306173904C185592680 @default.
• W4306173904 hasConceptScore W4306173904C187831198 @default.
• W4306173904 hasConceptScore W4306173904C190283241 @default.
• W4306173904 hasConceptScore W4306173904C202751555 @default.
• W4306173904 hasConceptScore W4306173904C203014093 @default.
• W4306173904 hasConceptScore W4306173904C207001950 @default.
• W4306173904 hasConceptScore W4306173904C2776914184 @default.
• W4306173904 hasConceptScore W4306173904C2777209026 @default.
• W4306173904 hasConceptScore W4306173904C31573885 @default.
• W4306173904 hasConceptScore W4306173904C55493867 @default.
• W4306173904 hasConceptScore W4306173904C86803240 @default.
• W4306173904 hasConceptScore W4306173904C95444343 @default.
• W4306173904 hasConceptScore W4306173904C98424977 @default.
• W4306173904 hasFunder F4320321001 @default.
• W4306173904 hasFunder F4320321543 @default.
• W4306173904 hasFunder F4320334897 @default.

• next