FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306174590> ?p ?o ?g. }

• W4306174590 abstract "This work presents a comparative analysis of the tyrosinase inhibitory effects of five citrus flavonoids, namely hesperetin, hesperidin, neohesperidin, naringenin and naringin. Visbile, fluorescence, and fourier transform infrared (FITR) spectroscopies, and molecular dynamic methods were employed to compare the anti-tyrosinase mechanisms of each flavonoid. Hesperetin, neohesperidin, naringenin and naringin exhibited potent inhibitory activities with IC50 values of 0.74 ± 0.05, 2.19 ± 0.03, 7.50 ± 9.82 and 24.94 ± 8.43 μmol/ml, respectively, all of which were higher than that of kojic acid (0.04 ± 0.02 μmol/ml). The enzymatic kinetics results suggested that hesperetin and naringenin were reversible inhibitors on tyrosinase in the mixed-type manner. H-bond and hydrophobic interactions were found to drive the binding of tyrosinase with hesperetin or naringenin, which subsequently changed the FTIR spectroscopy results by decreasing the α-helix ratio and increasing the β-turn, β-sheet and random coil ratio in tyrosinase. Molecular dynamics simulation not only verified some of the experimental results, but also suggested that the binding of hesperetin and naringenin to tyrosinase was spontaneous. The findings of this study indicate that citrus flavonoids are a promising dietary resource for tyrosinase inhibition. PRACTICAL APPLICATIONS: Hesperetin, hesperidin, neohesperidin, naringenin and naringin were typical citrus flavonoids that have anti-obesity, anti-oxidation, anti-inflammation and anti-diabetes activities. Current study suggested that hesperetin and naringenin were effective reversible inhibitors on tyrosinase in the mixed-type manner. Hesperetin and naringenin might serve as nutritional and chemical agents for regulating the tyrosinase activity to control melanin level in vivo." @default.
• W4306174590 created "2022-10-14" @default.
• W4306174590 creator A5050821600 @default.
• W4306174590 creator A5065520331 @default.
• W4306174590 creator A5068734668 @default.
• W4306174590 creator A5085098106 @default.
• W4306174590 date "2022-10-14" @default.
• W4306174590 modified "2023-09-29" @default.
• W4306174590 title "Inhibition characteristics and mechanism of tyrosinase using five citrus flavonoids: A spectroscopic and molecular dynamics simulation study" @default.
• W4306174590 cites W2007020504 @default.
• W4306174590 cites W2014952106 @default.
• W4306174590 cites W2040946337 @default.
• W4306174590 cites W2051232917 @default.
• W4306174590 cites W2069103604 @default.
• W4306174590 cites W2087042268 @default.
• W4306174590 cites W2128074664 @default.
• W4306174590 cites W2129257019 @default.
• W4306174590 cites W2340101947 @default.
• W4306174590 cites W2567582717 @default.
• W4306174590 cites W2596934880 @default.
• W4306174590 cites W2803516645 @default.
• W4306174590 cites W2810809478 @default.
• W4306174590 cites W2842099076 @default.
• W4306174590 cites W2903960063 @default.
• W4306174590 cites W2954992535 @default.
• W4306174590 cites W2980647718 @default.
• W4306174590 cites W2992473532 @default.
• W4306174590 cites W3039168002 @default.
• W4306174590 cites W3046604002 @default.
• W4306174590 cites W3087665608 @default.
• W4306174590 cites W3098347010 @default.
• W4306174590 cites W3106729219 @default.
• W4306174590 cites W3122609370 @default.
• W4306174590 cites W3127838643 @default.
• W4306174590 cites W3157035518 @default.
• W4306174590 cites W3210354230 @default.
• W4306174590 cites W4242007075 @default.
• W4306174590 doi "https://doi.org/10.1111/jfbc.14484" @default.
• W4306174590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36239431" @default.
• W4306174590 hasPublicationYear "2022" @default.
• W4306174590 type Work @default.
• W4306174590 citedByCount "0" @default.
• W4306174590 crossrefType "journal-article" @default.
• W4306174590 hasAuthorship W4306174590A5050821600 @default.
• W4306174590 hasAuthorship W4306174590A5065520331 @default.
• W4306174590 hasAuthorship W4306174590A5068734668 @default.
• W4306174590 hasAuthorship W4306174590A5085098106 @default.
• W4306174590 hasBestOaLocation W43061745901 @default.
• W4306174590 hasConcept C142724271 @default.
• W4306174590 hasConcept C181199279 @default.
• W4306174590 hasConcept C185592680 @default.
• W4306174590 hasConcept C204787440 @default.
• W4306174590 hasConcept C2776128092 @default.
• W4306174590 hasConcept C2776848411 @default.
• W4306174590 hasConcept C2777252647 @default.
• W4306174590 hasConcept C2777335409 @default.
• W4306174590 hasConcept C2778004101 @default.
• W4306174590 hasConcept C2779054382 @default.
• W4306174590 hasConcept C31903555 @default.
• W4306174590 hasConcept C43617362 @default.
• W4306174590 hasConcept C55493867 @default.
• W4306174590 hasConcept C71924100 @default.
• W4306174590 hasConcept C87554066 @default.
• W4306174590 hasConceptScore W4306174590C142724271 @default.
• W4306174590 hasConceptScore W4306174590C181199279 @default.
• W4306174590 hasConceptScore W4306174590C185592680 @default.
• W4306174590 hasConceptScore W4306174590C204787440 @default.
• W4306174590 hasConceptScore W4306174590C2776128092 @default.
• W4306174590 hasConceptScore W4306174590C2776848411 @default.
• W4306174590 hasConceptScore W4306174590C2777252647 @default.
• W4306174590 hasConceptScore W4306174590C2777335409 @default.
• W4306174590 hasConceptScore W4306174590C2778004101 @default.
• W4306174590 hasConceptScore W4306174590C2779054382 @default.
• W4306174590 hasConceptScore W4306174590C31903555 @default.
• W4306174590 hasConceptScore W4306174590C43617362 @default.
• W4306174590 hasConceptScore W4306174590C55493867 @default.
• W4306174590 hasConceptScore W4306174590C71924100 @default.
• W4306174590 hasConceptScore W4306174590C87554066 @default.
• W4306174590 hasIssue "12" @default.
• W4306174590 hasLocation W43061745901 @default.
• W4306174590 hasLocation W43061745902 @default.
• W4306174590 hasOpenAccess W4306174590 @default.
• W4306174590 hasPrimaryLocation W43061745901 @default.
• W4306174590 hasRelatedWork W2006949979 @default.
• W4306174590 hasRelatedWork W2081337364 @default.
• W4306174590 hasRelatedWork W2094617071 @default.
• W4306174590 hasRelatedWork W2105857789 @default.
• W4306174590 hasRelatedWork W2123292310 @default.
• W4306174590 hasRelatedWork W2163574617 @default.
• W4306174590 hasRelatedWork W2184559368 @default.
• W4306174590 hasRelatedWork W2206175437 @default.
• W4306174590 hasRelatedWork W2332037300 @default.
• W4306174590 hasRelatedWork W4306174590 @default.
• W4306174590 hasVolume "46" @default.
• W4306174590 isParatext "false" @default.
• W4306174590 isRetracted "false" @default.
• W4306174590 workType "article" @default.