FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306174706> ?p ?o ?g. }

• W4306174706 abstract "Abstract The myriad of available hepatocyte in vitro models provides researchers the possibility to select hepatocyte-like cells (HLCs) for specific research goals. However, direct comparison of hepatocyte models is currently challenging. We systematically searched the literature and compared different HLCs, but reported functions were limited to a small subset of hepatic functions. To enable a more comprehensive comparison, we developed an algorithm to compare transcriptomic data across studies that tested HLCs derived from hepatocytes, biliary cells, fibroblasts, and pluripotent stem cells, alongside primary human hepatocytes (PHHs). This revealed that no HLC covered the complete hepatic transcriptome, highlighting the importance of HLC selection. HLCs derived from hepatocytes had the highest transcriptional resemblance to PHHs regardless of the protocol, whereas the quality of fibroblasts and PSC derived HLCs varied depending on the protocol used. Finally, we developed and validated a web application (HLCompR) enabling comparison for specific pathways and addition of new HLCs. In conclusion, our comprehensive transcriptomic comparison of HLCs allows selection of HLCs for specific research questions and can guide improvements in culturing conditions." @default.
• W4306174706 created "2022-10-14" @default.
• W4306174706 creator A5012502103 @default.
• W4306174706 creator A5017351267 @default.
• W4306174706 creator A5023643503 @default.
• W4306174706 creator A5035486614 @default.
• W4306174706 creator A5037718854 @default.
• W4306174706 creator A5044299032 @default.
• W4306174706 creator A5052866316 @default.
• W4306174706 creator A5066374648 @default.
• W4306174706 creator A5083472766 @default.
• W4306174706 date "2022-10-14" @default.
• W4306174706 modified "2023-10-18" @default.
• W4306174706 title "A comprehensive transcriptomic comparison of hepatocyte model systems improves selection of models for experimental use" @default.
• W4306174706 cites W1097015697 @default.
• W4306174706 cites W1927990266 @default.
• W4306174706 cites W1968832732 @default.
• W4306174706 cites W1971482563 @default.
• W4306174706 cites W1971553024 @default.
• W4306174706 cites W1972967674 @default.
• W4306174706 cites W1982306858 @default.
• W4306174706 cites W1986947784 @default.
• W4306174706 cites W1993623398 @default.
• W4306174706 cites W2000318995 @default.
• W4306174706 cites W2001960993 @default.
• W4306174706 cites W2002880141 @default.
• W4306174706 cites W2014429225 @default.
• W4306174706 cites W2020755558 @default.
• W4306174706 cites W2061101624 @default.
• W4306174706 cites W2070050178 @default.
• W4306174706 cites W2072715165 @default.
• W4306174706 cites W2085652695 @default.
• W4306174706 cites W2090712756 @default.
• W4306174706 cites W2094689158 @default.
• W4306174706 cites W2099606984 @default.
• W4306174706 cites W2105782901 @default.
• W4306174706 cites W2113211673 @default.
• W4306174706 cites W2120057036 @default.
• W4306174706 cites W2120456698 @default.
• W4306174706 cites W2120865735 @default.
• W4306174706 cites W2128551987 @default.
• W4306174706 cites W2130953036 @default.
• W4306174706 cites W2159416713 @default.
• W4306174706 cites W2166676212 @default.
• W4306174706 cites W2170491580 @default.
• W4306174706 cites W2179438025 @default.
• W4306174706 cites W2312355042 @default.
• W4306174706 cites W2316384098 @default.
• W4306174706 cites W2370483985 @default.
• W4306174706 cites W2469087095 @default.
• W4306174706 cites W2496035205 @default.
• W4306174706 cites W2509887215 @default.
• W4306174706 cites W2520824012 @default.
• W4306174706 cites W2574853867 @default.
• W4306174706 cites W2580767461 @default.
• W4306174706 cites W2582045323 @default.
• W4306174706 cites W2605003947 @default.
• W4306174706 cites W2609596958 @default.
• W4306174706 cites W2740850972 @default.
• W4306174706 cites W2752871428 @default.
• W4306174706 cites W2757407722 @default.
• W4306174706 cites W2763196526 @default.
• W4306174706 cites W2769935541 @default.
• W4306174706 cites W2770650361 @default.
• W4306174706 cites W2792437803 @default.
• W4306174706 cites W2890166027 @default.
• W4306174706 cites W2897884788 @default.
• W4306174706 cites W2898572616 @default.
• W4306174706 cites W2900240008 @default.
• W4306174706 cites W2903148550 @default.
• W4306174706 cites W2904633962 @default.
• W4306174706 cites W2916303558 @default.
• W4306174706 cites W2917207851 @default.
• W4306174706 cites W2921906624 @default.
• W4306174706 cites W2941187779 @default.
• W4306174706 cites W2949380546 @default.
• W4306174706 cites W2956005250 @default.
• W4306174706 cites W2959566316 @default.
• W4306174706 cites W2959932413 @default.
• W4306174706 cites W2976788389 @default.
• W4306174706 cites W2979309132 @default.
• W4306174706 cites W2980585186 @default.
• W4306174706 cites W2988904063 @default.
• W4306174706 cites W3009917167 @default.
• W4306174706 cites W3011371956 @default.
• W4306174706 cites W3013894747 @default.
• W4306174706 cites W3035489465 @default.
• W4306174706 cites W3090039901 @default.
• W4306174706 cites W3093748727 @default.
• W4306174706 cites W3110547538 @default.
• W4306174706 cites W3126918553 @default.
• W4306174706 cites W3132378403 @default.
• W4306174706 cites W3162039171 @default.
• W4306174706 cites W3198999861 @default.
• W4306174706 cites W3207885470 @default.
• W4306174706 cites W4210848872 @default.
• W4306174706 cites W4212806498 @default.
• W4306174706 cites W2971205254 @default.
• W4306174706 doi "https://doi.org/10.1038/s42003-022-04046-9" @default.
• W4306174706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36241695" @default.

• next