Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306174838> ?p ?o ?g. }
- W4306174838 abstract "ABSTRACT The IS200/IS605 family are abundant insertion sequences associated with one of the most numerous genes in nature, tnpB . Sequence homologies suggest that transposon-borne TnpB may be an evolutionary precursor to CRISPR-Cas system effector proteins, and TnpB has been shown to function as a Cas-like programmable DNA endonuclease. However, the role of TnpB in transposition and its contributions to genome dynamics remain elusive. Using a suite of fluorescent reporters coupled to transposition, we show that TnpB increases IS608-transposon activity and prevents transposon loss from genomes. Analyzing our results through a mathematical model of transposon dynamics, we discuss the multifaceted roles TnpB may play in transposon regulation. The mutually beneficial transposon-TnpB interaction may explain the prevalence of tnpB , creating conditions for the proliferation and appropriation of TnpB’s RNA-guided endonuclease activity for adaptive immunity." @default.
- W4306174838 created "2022-10-14" @default.
- W4306174838 creator A5007494083 @default.
- W4306174838 creator A5018140114 @default.
- W4306174838 date "2022-10-14" @default.
- W4306174838 modified "2023-09-24" @default.
- W4306174838 title "IS200/IS605 Family-Associated TnpB Increases Transposon Activity and Retention" @default.
- W4306174838 cites W1861303653 @default.
- W4306174838 cites W1965552201 @default.
- W4306174838 cites W1970168814 @default.
- W4306174838 cites W1985886752 @default.
- W4306174838 cites W1988257465 @default.
- W4306174838 cites W2003845426 @default.
- W4306174838 cites W2005634944 @default.
- W4306174838 cites W2011016615 @default.
- W4306174838 cites W2026277222 @default.
- W4306174838 cites W2026519705 @default.
- W4306174838 cites W2027674837 @default.
- W4306174838 cites W2036330256 @default.
- W4306174838 cites W2045435533 @default.
- W4306174838 cites W2046614733 @default.
- W4306174838 cites W2050119054 @default.
- W4306174838 cites W2059173951 @default.
- W4306174838 cites W2062596730 @default.
- W4306174838 cites W2070807615 @default.
- W4306174838 cites W2075224242 @default.
- W4306174838 cites W2088981347 @default.
- W4306174838 cites W2093848749 @default.
- W4306174838 cites W2106673630 @default.
- W4306174838 cites W2110399041 @default.
- W4306174838 cites W2118746294 @default.
- W4306174838 cites W2123883764 @default.
- W4306174838 cites W2124583402 @default.
- W4306174838 cites W2127646692 @default.
- W4306174838 cites W2129717376 @default.
- W4306174838 cites W2137874473 @default.
- W4306174838 cites W2143273691 @default.
- W4306174838 cites W2146496997 @default.
- W4306174838 cites W2148641266 @default.
- W4306174838 cites W2159542598 @default.
- W4306174838 cites W2159933659 @default.
- W4306174838 cites W2160234166 @default.
- W4306174838 cites W2162049340 @default.
- W4306174838 cites W2167091086 @default.
- W4306174838 cites W2169315049 @default.
- W4306174838 cites W2171976338 @default.
- W4306174838 cites W2197109003 @default.
- W4306174838 cites W2404105638 @default.
- W4306174838 cites W2435574843 @default.
- W4306174838 cites W2580171608 @default.
- W4306174838 cites W2611694733 @default.
- W4306174838 cites W2623862783 @default.
- W4306174838 cites W2754732683 @default.
- W4306174838 cites W2914329775 @default.
- W4306174838 cites W3017511994 @default.
- W4306174838 cites W3198344223 @default.
- W4306174838 cites W3203405076 @default.
- W4306174838 cites W3203662917 @default.
- W4306174838 cites W3205408718 @default.
- W4306174838 cites W903719358 @default.
- W4306174838 doi "https://doi.org/10.1101/2022.10.12.511977" @default.
- W4306174838 hasPublicationYear "2022" @default.
- W4306174838 type Work @default.
- W4306174838 citedByCount "0" @default.
- W4306174838 crossrefType "posted-content" @default.
- W4306174838 hasAuthorship W4306174838A5007494083 @default.
- W4306174838 hasAuthorship W4306174838A5018140114 @default.
- W4306174838 hasBestOaLocation W43061748381 @default.
- W4306174838 hasConcept C104317684 @default.
- W4306174838 hasConcept C105793898 @default.
- W4306174838 hasConcept C12455157 @default.
- W4306174838 hasConcept C138885662 @default.
- W4306174838 hasConcept C141231307 @default.
- W4306174838 hasConcept C2777028655 @default.
- W4306174838 hasConcept C41895202 @default.
- W4306174838 hasConcept C4918238 @default.
- W4306174838 hasConcept C51785407 @default.
- W4306174838 hasConcept C54355233 @default.
- W4306174838 hasConcept C552990157 @default.
- W4306174838 hasConcept C70721500 @default.
- W4306174838 hasConcept C86803240 @default.
- W4306174838 hasConcept C95444343 @default.
- W4306174838 hasConceptScore W4306174838C104317684 @default.
- W4306174838 hasConceptScore W4306174838C105793898 @default.
- W4306174838 hasConceptScore W4306174838C12455157 @default.
- W4306174838 hasConceptScore W4306174838C138885662 @default.
- W4306174838 hasConceptScore W4306174838C141231307 @default.
- W4306174838 hasConceptScore W4306174838C2777028655 @default.
- W4306174838 hasConceptScore W4306174838C41895202 @default.
- W4306174838 hasConceptScore W4306174838C4918238 @default.
- W4306174838 hasConceptScore W4306174838C51785407 @default.
- W4306174838 hasConceptScore W4306174838C54355233 @default.
- W4306174838 hasConceptScore W4306174838C552990157 @default.
- W4306174838 hasConceptScore W4306174838C70721500 @default.
- W4306174838 hasConceptScore W4306174838C86803240 @default.
- W4306174838 hasConceptScore W4306174838C95444343 @default.
- W4306174838 hasLocation W43061748381 @default.
- W4306174838 hasOpenAccess W4306174838 @default.
- W4306174838 hasPrimaryLocation W43061748381 @default.
- W4306174838 hasRelatedWork W1967173988 @default.