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- W4306175092 endingPage "16928" @default.
- W4306175092 startingPage "16914" @default.
- W4306175092 abstract "Five fluorescent ONO donor-based organotin(IV) complexes, [SnIV(L1-5)Ph2] (1-5), were synthesized by the one-pot reaction method and fully characterized spectroscopically including the single-crystal X-ray diffraction studies of 2-4. Detailed photophysical characterization of all compounds was performed. All the compounds exhibited high luminescent properties with a quantum yield of 17-53%. Additionally, the results of cellular permeability analysis suggest that they are lipophilic and easily absorbed by cells. Confocal microscopy was used to examine the live cell imaging capability of 1-5, and the results show that the compounds are mostly internalized in mitochondria and exhibit negligible cytotoxicity at imaging concentration. Also, 1-5 exhibited high photostability as compared to the commercial dye and can be used in long-term real-time tracking of cell organelles. Also, it is found that the probes (1-5) are highly tolerable during the changes in mitochondrial morphology. Thus, this kind of low-toxic organotin-based fluorescent probe can assist in imaging of mitochondria within living cells and tracking changes in their morphology." @default.
- W4306175092 created "2022-10-14" @default.
- W4306175092 creator A5004937278 @default.
- W4306175092 creator A5043852571 @default.
- W4306175092 creator A5062357422 @default.
- W4306175092 creator A5071420540 @default.
- W4306175092 creator A5079615736 @default.
- W4306175092 date "2022-10-14" @default.
- W4306175092 modified "2023-09-23" @default.
- W4306175092 title "Mitochondria-Targeted Luminescent Organotin(IV) Complexes: Synthesis, Photophysical Characterization, and Live Cell Imaging" @default.
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