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- W4306177511 abstract "Introduction: Management of postoperative pain remains paramount for patients and surgeons. Therapeutic options that are novel and efficacious which provide alternatives to opioid analgesics; offer an opportunity to attenuate or block nocioceptive pathways directly associated with the surgical procedure. Modeling of surgical pain in animal models is critical to evaluate therapeuctics. We describe our preliminary experience with the Orofacial Pain Assessment Device (OPAD) to assess pain through a reward/conflict paradigm providing a humane way of testing a novel therapeutic implant systems. Methods: The Orofacial Pain Assessment Device (OPAD) uses a reward/conflict assay which allows a rodent to choose between receiving a reinforcing reward or escaping an aversive stimulus thus controlling the amount of pain it feels during a session Rodents are first trained to press their faces into temperature controlled thermodes in order to gain access to a food bottle containing a liquid reward. After training, the stimulus temperature can be heated or cooled and differences in responding can indicate the level of nociception or analgesia the animal perceives. Results: the OPAD protocol which incorporate various oral-facial surgical incisions reveals the applicability of and the potential to assess analgesic effect of surgical incisional implants. Conclusion: Use of the Orofacial Pain Assessment Device (OPAD) facilitates surgical modeling of oral-facial surgical pain and the utility in assessment of novel surgical incisional implants in analgesia for post operative care and management." @default.
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- W4306177511 date "2022-10-17" @default.
- W4306177511 modified "2023-10-17" @default.
- W4306177511 title "Surgical Pain Modeling with an Operant Orofacial Pain Assessment Device (OPAD)" @default.
- W4306177511 doi "https://doi.org/10.1097/01.xcs.0000896300.74791.16" @default.
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