Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306177725> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4306177725 endingPage "S94" @default.
- W4306177725 startingPage "S94" @default.
- W4306177725 abstract "Introduction: Intraoperative irrigation, usually with normal saline (NS), aids in bleeding identification and management. We investigated the effect of different irrigation fluids, with additives, on hemostasis using two bleeding models. Methods: C57BL/6J mice were subjected to a tail bleed model or uncontrolled abdominal hemorrhage via liver laceration followed by abdominal cavity irrigation. We compared NS, Lactated Ringers (LR), and PlasmaLyte. We examined NS and LR at different temperatures. NS or LR with calcium (Ca), or tranexamic acid (TXA) were studied. Results: Compared with room temperature (RT), increasing the temperature to 37°C and 42°C reduced tail vein bleeding times significantly in both NS and LR (all p < 0.001), with no significant differences between the two fluids. At RT, LR, but not PlasmaLyte, substantially reduced bleeding times in comparison to NS (p < 0.0001). Liver injury blood loss was lower in LR (p < 0.01). NS supplemented with 1 mEq/mL of Ca decreased bleeding time and blood loss volume (p < 0.01, and p < 0.0001, respectively), to similar levels as LR. NS with 150mg/mL of TXA markedly reduced bleeding time (p < 0.0001), and NS with 62.5 mg/mL TXA decreased blood loss (p < 0.01). Conclusion: While Ca- and TXA-supplemented NS reduced bleeding, LR remained superior to all irrigation fluid compositions. As LR contains Ca, and Ca-supplemented NS mirrored LR in response, Ca presence in the irrigation fluid seems key to improving solution’s hemostatic ability. Since warming the fluids normalized the choice of agents, the data suggest that Ca-containing fluids such as LR may be more suitable for hemostasis when used at RT." @default.
- W4306177725 created "2022-10-14" @default.
- W4306177725 creator A5005234320 @default.
- W4306177725 creator A5006566851 @default.
- W4306177725 creator A5017848559 @default.
- W4306177725 creator A5029058133 @default.
- W4306177725 creator A5030335587 @default.
- W4306177725 creator A5031256935 @default.
- W4306177725 creator A5051805841 @default.
- W4306177725 creator A5072764026 @default.
- W4306177725 date "2022-10-17" @default.
- W4306177725 modified "2023-09-27" @default.
- W4306177725 title "Irrigation Fluid Composition Affects Hemostasis in Murine Bleeding Models" @default.
- W4306177725 doi "https://doi.org/10.1097/01.xcs.0000896532.61053.4c" @default.
- W4306177725 hasPublicationYear "2022" @default.
- W4306177725 type Work @default.
- W4306177725 citedByCount "0" @default.
- W4306177725 crossrefType "journal-article" @default.
- W4306177725 hasAuthorship W4306177725A5005234320 @default.
- W4306177725 hasAuthorship W4306177725A5006566851 @default.
- W4306177725 hasAuthorship W4306177725A5017848559 @default.
- W4306177725 hasAuthorship W4306177725A5029058133 @default.
- W4306177725 hasAuthorship W4306177725A5030335587 @default.
- W4306177725 hasAuthorship W4306177725A5031256935 @default.
- W4306177725 hasAuthorship W4306177725A5051805841 @default.
- W4306177725 hasAuthorship W4306177725A5072764026 @default.
- W4306177725 hasBestOaLocation W43061777251 @default.
- W4306177725 hasConcept C126322002 @default.
- W4306177725 hasConcept C141071460 @default.
- W4306177725 hasConcept C2777397205 @default.
- W4306177725 hasConcept C2778589496 @default.
- W4306177725 hasConcept C2779216453 @default.
- W4306177725 hasConcept C2779637338 @default.
- W4306177725 hasConcept C2991743468 @default.
- W4306177725 hasConcept C2993802102 @default.
- W4306177725 hasConcept C42219234 @default.
- W4306177725 hasConcept C71924100 @default.
- W4306177725 hasConcept C89560881 @default.
- W4306177725 hasConceptScore W4306177725C126322002 @default.
- W4306177725 hasConceptScore W4306177725C141071460 @default.
- W4306177725 hasConceptScore W4306177725C2777397205 @default.
- W4306177725 hasConceptScore W4306177725C2778589496 @default.
- W4306177725 hasConceptScore W4306177725C2779216453 @default.
- W4306177725 hasConceptScore W4306177725C2779637338 @default.
- W4306177725 hasConceptScore W4306177725C2991743468 @default.
- W4306177725 hasConceptScore W4306177725C2993802102 @default.
- W4306177725 hasConceptScore W4306177725C42219234 @default.
- W4306177725 hasConceptScore W4306177725C71924100 @default.
- W4306177725 hasConceptScore W4306177725C89560881 @default.
- W4306177725 hasIssue "5" @default.
- W4306177725 hasLocation W43061777251 @default.
- W4306177725 hasLocation W43061777252 @default.
- W4306177725 hasOpenAccess W4306177725 @default.
- W4306177725 hasPrimaryLocation W43061777251 @default.
- W4306177725 hasRelatedWork W1987966673 @default.
- W4306177725 hasRelatedWork W2006780955 @default.
- W4306177725 hasRelatedWork W2022984218 @default.
- W4306177725 hasRelatedWork W2124496219 @default.
- W4306177725 hasRelatedWork W2153204815 @default.
- W4306177725 hasRelatedWork W2322603431 @default.
- W4306177725 hasRelatedWork W3095573563 @default.
- W4306177725 hasRelatedWork W4306177725 @default.
- W4306177725 hasRelatedWork W4309363371 @default.
- W4306177725 hasRelatedWork W810607527 @default.
- W4306177725 hasVolume "235" @default.
- W4306177725 isParatext "false" @default.
- W4306177725 isRetracted "false" @default.
- W4306177725 workType "article" @default.