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- W4306177730 abstract "Introduction: A potential solution to increase hearts available for transplantation is to use extended criteria donor hearts that are deemed unacceptable at initial evaluation. This study uses normothermic ex vivo heart perfusion (NEVHP) to resuscitate, recover, and assess performance of hearts after prolonged cold ischemia time. METHODS: Piglet (6 to 10 kg) hearts were procured after delivering antegrade cardioplegia. Catheters were placed in the left ventricle (functional assessment), aorta (inflow), and pulmonary artery (outflow) to support NEVHP, followed by either initiation of NEVHP (“direct group,” n = 5) or cold static storage in CoStorSol solution at 5°C for 12 hours (“12-hour group,” n = 5) or 24 hours (“24-hour group,” n = 5). All hearts were recovered and supported using NEVHP with in-parallel hemofiltration. Coronary perfusion was maintained at 1 mL/min/g. One-way ANOVA was used for statistical analysis. RESULTS: All hearts were resuscitated to normal sinus rhythm and were viable at 8 hours NEVHP. There were no significant differences between the direct, 12-hour, and 24-hour groups in hemodynamic or metabolic performance at the end of NEVHP. Mean heart rate was 95 ± 4, 90 ± 2, and 101 ± 3 beats per minute (p = 0.08); left ventricle pressure was 45 ± 4.7, 51 ± 5.0, and 56.0 ± 3.0 mmHg (p = 0.24); coronary resistance was 0.77 ± 0.29, 0.76 ± 0.18, and 0.48 ± 0.13 mmHg/mL/min (p = 0.08); lactate was 2.6 ± 0.3, 2.84 ± 0.3, and 3.5 ± 0.2 mmol/L (p = 0.10); and oxygen consumption was 0.015 ± 0.001, 0.021 ± 0.004, and 0.015 ± 0.004 mL/min/g (p = 0.24) for the direct, 12-hour, and 24-hour groups, respectively. Conclusion: Use of extended criteria donor hearts would increase organs available for transplantation. NEVHP with hemofiltration offers a solution to successfully recover and assess these hearts while maintaining organ performance." @default.
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- W4306177730 date "2022-10-17" @default.
- W4306177730 modified "2023-10-14" @default.
- W4306177730 title "Normothermic Ex Vivo Perfusion with Hemofiltration Maintains Heart Performance after Prolonged Cold Ischemia Time" @default.
- W4306177730 doi "https://doi.org/10.1097/01.xcs.0000893192.61417.da" @default.
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