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- W4306177828 abstract "INTRODUCTION: Positive surgical margin after mastectomy occurs in approximately 10% of women and increases risk of recurrence and morbidity. The aim of this study was to identify factors which may confer a higher risk of margin positivity after mastectomy. METHODS: Women with Tis–T3 breast cancer who underwent mastectomy as definitive operation were retrospectively analyzed from 2014 to 2018. Comparison of clinicopathologic data was made between patients with negative margins (greater than or equal to 1 mm) and close (less than 1 mm) or positive margins by univariate and multivariate statistical analyses. RESULTS: During the study period, 942 women underwent mastectomy. Negative margins were reported for 798 (85%) women, whereas 144 (15%) women experienced close (97/144) or positive (33/144) margin. Re-excision of margin was performed for 37 patients (4%), and 9 of 37 (24%) had residual cancer after re-excision. On multivariate analysis, treatment with neoadjuvant chemotherapy (0.39 odds ratio [OR], 95% CI 0.22–0.70, p = 0.002) and increased age (0.97 OR, 95% CI 0.96–0.99, p = 0.003) decreased the risk of close or positive margin, whereas Asian race (5.72 OR, 95% CI 1.56–21.02, p < 0.009), increased tumor to breast size ratio (2.07 OR, 95% CI 1.57–2.73, p < 0.001), lower inner quadrant (LIQ) tumor location (3.24 OR, 95% CI 1.64–6.41, p < 0.001), and immediate reconstruction (1.66 OR, 95% CI 1.00–2.74, p = 0.048) increased the risk of close or positive margin status (Table). CONCLUSION: Increasing age, neoadjuvant chemotherapy, Asian race, increased tumor size to breast weight ratio, LIQ tumor location, and immediate reconstruction independently predict close or positive margin status after mastectomy. Table. - Multivariate Logistic Regression for Margin Positivity Characteristic Adjusted OR 95% CI p Value Neoadjuvant chemotherapy 0.39 0.22–0.70 0.002 Age (year) 0.97 0.96–0.99 0.003 Asian/Pacific Islander 5.72 1.56 –1.02 0.009 Tumor size/Breast weight (log[cm/kg+1]) 2.07 1.57–2.73 < 0.001 Tumor location (LIQ) 3.24 1.64–6.41 <0.001 Immediate recontruction 1.66 1.00–2.74 0.048" @default.
- W4306177828 created "2022-10-14" @default.
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- W4306177828 date "2022-10-17" @default.
- W4306177828 modified "2023-09-27" @default.
- W4306177828 title "Identifying Factors Predicting Margin Positivity After Mastectomy" @default.
- W4306177828 doi "https://doi.org/10.1097/01.xcs.0000893164.20550.fa" @default.
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