Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306178968> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4306178968 endingPage "S261" @default.
- W4306178968 startingPage "S261" @default.
- W4306178968 abstract "INTRODUCTION: Esophageal cancer (EC) is known to originate in the setting of chronic inflammation. While previous studies have sought to understand the role of inflammatory signaling in EC, little is known regarding the effect of these immunologic changes on patient outcomes. Several studies have linked serum cytokine levels with prognostic measures; however, these studies consist primarily of patients with esophageal squamous cell carcinoma (ESCC) with few esophageal adenocarcinoma (EAC) cases. The objective was to evaluate the relationship between serum cytokine levels and survival in patients with EC and to validate these findings at the RNA level. METHODS: 37 serum cytokines were profiled at time of resection using multiplex ELISA in 47 patients (42 EAC, 5 ESCC). Cytokine levels were binarized in relation to the median and assessed using Log-rank tests and Cox Regression models. Findings were validated at the RNA-level using TCGA Esophageal Carcinoma cohort (77 EAC, 81 ESCC). RESULTS: Univariate analysis revealed serum Interleukin-4 (IL-4) was associated with survival (p = 0.042) (Figure). Multivariable analysis showed that high serum IL-4, pathologic stage, and body mass index were strong and independent predictors of survival (p < 0.001, p < 0.001 and p = 0.039). Univariate analysis of IL4 RNA levels revealed that IL4 was associated with survival (p = 0.012). Multivariable analysis showed that high IL4 expression, and post-surgical stage were strong and independent predictors of patient survival (p = 0.01, p < 0.001 respectively).FigureCONCLUSION: These results show that IL4 levels associate with survival in EC. Notably, this relationship is independent of clinical/pathologic staging, indicating its potential as a novel prognostic biomarker in EC." @default.
- W4306178968 created "2022-10-14" @default.
- W4306178968 creator A5005499715 @default.
- W4306178968 creator A5016545000 @default.
- W4306178968 creator A5036686598 @default.
- W4306178968 creator A5041170431 @default.
- W4306178968 creator A5051084043 @default.
- W4306178968 creator A5058665938 @default.
- W4306178968 creator A5073837400 @default.
- W4306178968 creator A5081334626 @default.
- W4306178968 creator A5091311134 @default.
- W4306178968 date "2022-10-17" @default.
- W4306178968 modified "2023-09-26" @default.
- W4306178968 title "Interleukin-4 Levels Predict Survival Independent of Pathologic Stage in a Mixed Esophageal Cancer Cohort" @default.
- W4306178968 doi "https://doi.org/10.1097/01.xcs.0000895060.15681.f3" @default.
- W4306178968 hasPublicationYear "2022" @default.
- W4306178968 type Work @default.
- W4306178968 citedByCount "0" @default.
- W4306178968 crossrefType "journal-article" @default.
- W4306178968 hasAuthorship W4306178968A5005499715 @default.
- W4306178968 hasAuthorship W4306178968A5016545000 @default.
- W4306178968 hasAuthorship W4306178968A5036686598 @default.
- W4306178968 hasAuthorship W4306178968A5041170431 @default.
- W4306178968 hasAuthorship W4306178968A5051084043 @default.
- W4306178968 hasAuthorship W4306178968A5058665938 @default.
- W4306178968 hasAuthorship W4306178968A5073837400 @default.
- W4306178968 hasAuthorship W4306178968A5081334626 @default.
- W4306178968 hasAuthorship W4306178968A5091311134 @default.
- W4306178968 hasBestOaLocation W43061789681 @default.
- W4306178968 hasConcept C10515644 @default.
- W4306178968 hasConcept C121608353 @default.
- W4306178968 hasConcept C126322002 @default.
- W4306178968 hasConcept C143998085 @default.
- W4306178968 hasConcept C144301174 @default.
- W4306178968 hasConcept C146357865 @default.
- W4306178968 hasConcept C151730666 @default.
- W4306178968 hasConcept C191732599 @default.
- W4306178968 hasConcept C2777546739 @default.
- W4306178968 hasConcept C2778690821 @default.
- W4306178968 hasConcept C2779742542 @default.
- W4306178968 hasConcept C2781182431 @default.
- W4306178968 hasConcept C38180746 @default.
- W4306178968 hasConcept C50382708 @default.
- W4306178968 hasConcept C71924100 @default.
- W4306178968 hasConcept C72563966 @default.
- W4306178968 hasConcept C86803240 @default.
- W4306178968 hasConcept C90924648 @default.
- W4306178968 hasConceptScore W4306178968C10515644 @default.
- W4306178968 hasConceptScore W4306178968C121608353 @default.
- W4306178968 hasConceptScore W4306178968C126322002 @default.
- W4306178968 hasConceptScore W4306178968C143998085 @default.
- W4306178968 hasConceptScore W4306178968C144301174 @default.
- W4306178968 hasConceptScore W4306178968C146357865 @default.
- W4306178968 hasConceptScore W4306178968C151730666 @default.
- W4306178968 hasConceptScore W4306178968C191732599 @default.
- W4306178968 hasConceptScore W4306178968C2777546739 @default.
- W4306178968 hasConceptScore W4306178968C2778690821 @default.
- W4306178968 hasConceptScore W4306178968C2779742542 @default.
- W4306178968 hasConceptScore W4306178968C2781182431 @default.
- W4306178968 hasConceptScore W4306178968C38180746 @default.
- W4306178968 hasConceptScore W4306178968C50382708 @default.
- W4306178968 hasConceptScore W4306178968C71924100 @default.
- W4306178968 hasConceptScore W4306178968C72563966 @default.
- W4306178968 hasConceptScore W4306178968C86803240 @default.
- W4306178968 hasConceptScore W4306178968C90924648 @default.
- W4306178968 hasIssue "5" @default.
- W4306178968 hasLocation W43061789681 @default.
- W4306178968 hasLocation W43061789682 @default.
- W4306178968 hasOpenAccess W4306178968 @default.
- W4306178968 hasPrimaryLocation W43061789681 @default.
- W4306178968 hasRelatedWork W2361700749 @default.
- W4306178968 hasRelatedWork W2361948491 @default.
- W4306178968 hasRelatedWork W2372105188 @default.
- W4306178968 hasRelatedWork W2387412458 @default.
- W4306178968 hasRelatedWork W2391515199 @default.
- W4306178968 hasRelatedWork W2392151514 @default.
- W4306178968 hasRelatedWork W2561077962 @default.
- W4306178968 hasRelatedWork W3032162066 @default.
- W4306178968 hasRelatedWork W4361918880 @default.
- W4306178968 hasRelatedWork W2467631982 @default.
- W4306178968 hasVolume "235" @default.
- W4306178968 isParatext "false" @default.
- W4306178968 isRetracted "false" @default.
- W4306178968 workType "article" @default.