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• W4306179214 endingPage "38" @default.
• W4306179214 startingPage "17" @default.
• W4306179214 abstract "The brain ventricular system (BVS) consists of the brain ventricles and channels filled with cerebrospinal fluid (CSF). Disturbance of CSF flow has been linked to neurodegenerative diseases including hydrocephalus, which manifests as an expansion of the BVS. These relatively common developmental disorders have been observed in humans and domesticated animals and linked to functional deficiency of the choroid plexus (CP) or ependymal cells that generate CSF, or the motile cilia that drive CSF flow. Vertebrates with horizontal body posture have ancient evolutionary adaptations to assist CSF flow such as the Reissner fiber, lost in human adults upon transition to bipedal locomotion. The underlying causes of hydrocephalus and related diseases such as scoliosis could be elucidated through several recently-developed animal models including rodents (mice, rats, hamsters) and zebrafish. Owing to their horizontal body posture and the way that gravity affects their CSF flow, the mammalian models differ significantly from humans. In contrast, the fish swim against the current and experience the forward-to-backward mechanical force analogous to that caused by gravity in humans. On the other side of the spectrum of BVS anomalies, there is “slit-ventricle” syndrome (microcephaly), which develops due to insufficient inflation of the BVS. Recent advances in the functional genetics of zebrafish revealed novel genetic elements in the development of the BVS and the CSF circulation. The aim of this review is to reveal the common elements among the morphologically different BVSs of zebrafish, a typical representative of teleosts, and vertebrates in general, and to illustrate the features of the zebrafish model useful for studies of the BVS, choroid plexus (CP), and CSF flow. The molecular elements of the putative developmental mechanism will be discussed." @default.
• W4306179214 created "2022-10-14" @default.
• W4306179214 creator A5023303739 @default.
• W4306179214 date "2023-01-01" @default.
• W4306179214 modified "2023-10-14" @default.
• W4306179214 title "Development of the ventricles, choroid plexus and CSF outflow system" @default.
• W4306179214 cites W1106124941 @default.
• W4306179214 cites W136999890 @default.
• W4306179214 cites W1495762998 @default.
• W4306179214 cites W1519192001 @default.
• W4306179214 cites W1520987766 @default.
• W4306179214 cites W1600456231 @default.
• W4306179214 cites W1604922098 @default.
• W4306179214 cites W1609321187 @default.
• W4306179214 cites W1759652240 @default.
• W4306179214 cites W1820396036 @default.
• W4306179214 cites W1941456052 @default.
• W4306179214 cites W1964938632 @default.
• W4306179214 cites W1965536104 @default.
• W4306179214 cites W1966242446 @default.
• W4306179214 cites W1970215778 @default.
• W4306179214 cites W1971845673 @default.
• W4306179214 cites W1973445688 @default.
• W4306179214 cites W1973613551 @default.
• W4306179214 cites W1974557957 @default.
• W4306179214 cites W1975537268 @default.
• W4306179214 cites W1975914585 @default.
• W4306179214 cites W1977437828 @default.
• W4306179214 cites W1979356351 @default.
• W4306179214 cites W1981239255 @default.
• W4306179214 cites W1983127906 @default.
• W4306179214 cites W1984447534 @default.
• W4306179214 cites W1985860649 @default.
• W4306179214 cites W1987283412 @default.
• W4306179214 cites W1988505512 @default.
• W4306179214 cites W1989170134 @default.
• W4306179214 cites W1991746958 @default.
• W4306179214 cites W1991923928 @default.
• W4306179214 cites W1992434633 @default.
• W4306179214 cites W1993691318 @default.
• W4306179214 cites W1993792647 @default.
• W4306179214 cites W1994547628 @default.
• W4306179214 cites W1995865557 @default.
• W4306179214 cites W1997701227 @default.
• W4306179214 cites W1999324788 @default.
• W4306179214 cites W1999719590 @default.
• W4306179214 cites W2001967944 @default.
• W4306179214 cites W2004134964 @default.
• W4306179214 cites W2004207259 @default.
• W4306179214 cites W2004343985 @default.
• W4306179214 cites W2004710189 @default.
• W4306179214 cites W2006340543 @default.
• W4306179214 cites W2006612391 @default.
• W4306179214 cites W2010898189 @default.
• W4306179214 cites W2012029881 @default.
• W4306179214 cites W2014602359 @default.
• W4306179214 cites W2016266176 @default.
• W4306179214 cites W2018496368 @default.
• W4306179214 cites W2023770931 @default.
• W4306179214 cites W2024693975 @default.
• W4306179214 cites W2024706272 @default.
• W4306179214 cites W2026842789 @default.
• W4306179214 cites W2027336873 @default.
• W4306179214 cites W2028369178 @default.
• W4306179214 cites W2030131303 @default.
• W4306179214 cites W2033005195 @default.
• W4306179214 cites W2035476209 @default.
• W4306179214 cites W2035731516 @default.
• W4306179214 cites W2035800740 @default.
• W4306179214 cites W2036439165 @default.
• W4306179214 cites W2039905092 @default.
• W4306179214 cites W2040170948 @default.
• W4306179214 cites W2043127334 @default.
• W4306179214 cites W2044053412 @default.
• W4306179214 cites W2045468803 @default.
• W4306179214 cites W2046181899 @default.
• W4306179214 cites W2048102361 @default.
• W4306179214 cites W2048185125 @default.
• W4306179214 cites W2048501294 @default.
• W4306179214 cites W2050109696 @default.
• W4306179214 cites W2051150474 @default.
• W4306179214 cites W2052567591 @default.
• W4306179214 cites W2053026595 @default.
• W4306179214 cites W2055240093 @default.
• W4306179214 cites W2058525645 @default.
• W4306179214 cites W2060484877 @default.
• W4306179214 cites W2061041720 @default.
• W4306179214 cites W2062480745 @default.
• W4306179214 cites W2063374027 @default.
• W4306179214 cites W2063589636 @default.
• W4306179214 cites W2064957349 @default.
• W4306179214 cites W2066336965 @default.
• W4306179214 cites W2068003838 @default.
• W4306179214 cites W2070359873 @default.
• W4306179214 cites W2071194264 @default.
• W4306179214 cites W2071470207 @default.
• W4306179214 cites W2071629914 @default.
• W4306179214 cites W2074432560 @default.

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