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- W4306179971 abstract "In the present-day world, majority of the drugs used for treating dementia are ineffective and do not provide a proper cure for the disease. This is mainly due to the presence of blood–brain barrier (BBB) which restricts the drugs from reaching the target site. Moreover, dementia is not a single disease and consists of a number of neurodegenerative conditions that alter brain functions. As a consequence, there lies a need for coming up with strategies to bypass the BBB and effect the target site. Recently, nanocarriers have been a promising alternative to ferry the drug through BBB to the site of interest. Due to their extraordinary properties, micelles are successful in localizing in the brain and exhibit improved performance than the plain drug. Surface modification with different peptides/proteins/ligands further leads to receptor-mediated targeting of the micelles. They take up different pathways to restore proper brain functioning in different types of dementia. Generally, dialysis, direct dissolution, and solvent evaporation methods are employed for the synthesis of the micelles. Improved brain distribution has been observed when the micelles are administered via oral, intravenous, and intranasal routes. Interestingly, micelles are not only capable of cellular targeting but also target specific cell organelles. Nowadays, micelles are also used to carry genetic materials in the form of siRNA, shRNA, mRNA, etc., to the brain resulting in manipulation of the desired gene. Although there is sufficient evidence to prove the effectiveness of micelles, the study results are only restricted to in vitro and preclinical investigations. Therefore, extensive studies are needed to be performed in near future to enter the next stage of research, that is, clinical trials. A successful commercial product would lead to a dynamic improvement in the health conditions of dementia patients as well as minimize the treatment cost." @default.
- W4306179971 created "2022-10-14" @default.
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- W4306179971 date "2023-01-01" @default.
- W4306179971 modified "2023-10-14" @default.
- W4306179971 title "Micelles-based drug delivery for dementia" @default.
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- W4306179971 doi "https://doi.org/10.1016/b978-0-12-824331-2.00002-9" @default.
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