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- W4306179980 abstract "Fusion of pyrimidine with different heterocyclics yields a variety of pyrimidine-based scaffolds, which represent a class of privileged structures in chemistry due to their presence in various bioactive agents. Fused-pyrimidine scaffolds are used as templates to develop a diversity of compounds having applications as antiviral, anti-tumor, anti-allergic, antihypertensive, anticancer, antioxidant and hepatoprotective agents. Compounds derived from these scaffolds are synthesized through different retrosynthetic approaches that include multi-component reaction and microwave-assisted reaction. Here, in this review, the literature on pyrimidine-based scaffolds developed through the fusion of pyrimidine with varied six-membered rings containing nitrogen (pyridopyrimidine, pyrimidopyrimidine and pteridine), oxygen (pyranopyrimidine and coumarinpyrimidine), and sulphur (thiopyranopyrimidine) is compiled with an emphasis on structure-activity relationships, synthetic strategies and biological properties. These pyrimidine-fused scaffolds are further classified based on their bond of fusion with the six-membered rings. This chapter is an attempt to provide comprehensive and updated information on synthetic approaches, medicinal chemistry and biological activities of various six-membered rings (with N, O or S) fused with a pyrimidine." @default.
- W4306179980 created "2022-10-14" @default.
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- W4306179980 date "2023-01-01" @default.
- W4306179980 modified "2023-10-14" @default.
- W4306179980 title "Six-membered ring (with N, O or S) fused pyrimidine-based derivatives and biological properties" @default.
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- W4306179980 doi "https://doi.org/10.1016/b978-0-443-18616-5.00012-0" @default.
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