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• W4306181807 abstract "We developed a simple method to fabricate high aspect ratio 3D microfluidic devices, as geometrically optimized microenvironment for long-term culture of 3D tumor models (i.e., spheroids). The microfluidic device consists of a 2 mm-wide central chamber for spheroid culture flanked by two 976 μm-wide side channels for medium and nutrients supply. To cage hydrogel inside the central chamber, the side channels are isolated using pillar arrays whose geometry has been carefully designed. The role of the height of the central chamber on the growth of heterotypic pancreatic tumor spheroids, made of cancer cells and fibroblasts, was first studied. Predictably, in the 100 μm-high chamber the spheroid cannot grow vertically and exhibits an elongated and horizontally flattened shape. Instead, the tumor spheroid can grow freely in the 300 and 500 μm-high chambers and the invasion of individual cells in the surrounding matrix can be observed over a period of 20 days of culture. In a second step, we investigated an original microfluidic design with two distinct heights for the central chamber and the side channels. Such a design, which promotes better resist adherence, could be 3D printed without any resist residue after development. The heterotypic spheroids cultured in this two-level device revealed progressive cell growth and migration, validating this new approach." @default.
• W4306181807 created "2022-10-14" @default.
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• W4306181807 date "2023-01-01" @default.
• W4306181807 modified "2023-09-26" @default.
• W4306181807 title "Fabrication of high aspect ratio microfluidic devices for long term in vitro culture of 3D tumor models" @default.
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• W4306181807 doi "https://doi.org/10.1016/j.mee.2022.111898" @default.
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