FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306194414> ?p ?o ?g. }

• W4306194414 endingPage "H1067" @default.
• W4306194414 startingPage "H1057" @default.
• W4306194414 abstract "With the increasing appreciation for sex as a biological variable and the inclusion of female mice in research, it is important to understand the influence of the estrous cycle on physiological function. Sex hormones are known to modulate vascular function, but the effects of the mouse estrous cycle phase on arterial stiffness, endothelial function, and arterial estrogen receptor expression remain unknown. In 23 female C57BL/6 mice (6 mo of age), we determined the estrous cycle stage via vaginal cytology and plasma hormone concentrations. Aortic stiffness, assessed by pulse wave velocity, was lower during the estrus phase compared with diestrus. In ex vivo assessment of isolated pressurized mesenteric and posterior cerebral arteries, the responses to acetylcholine, insulin, and sodium nitroprusside, as well as nitric oxide-mediated dilation, were not different between estrous cycle phases. In the aorta, expression of phosphorylated estrogen receptor-α was higher for mice in estrus compared with mice in proestrus. In the cerebral arteries, gene expression for estrogen receptor-β (Esr2) was lowest for mice in estrus compared with diestrus and proestrus. These results demonstrate that the estrus phase is associated with lower in vivo large artery stiffness in mice. In contrast, ex vivo resistance artery endothelial function is not different between estrous cycle phases. Estrogen receptor expression is modulated by the estrus cycle in an artery-dependent manner. These results suggest that the estrous cycle phase should be considered when measuring in vivo arterial stiffness in young female mice.NEW & NOTEWORTHY To design rigorous vascular research studies using young female rodents, the influence of the estrous cycle on vascular function must be known. We found that in vivo aortic stiffness was lower during estrus compared with the diestrus phase in female mice. In contrast, ex vivo mesenteric and cerebral artery endothelial function did not differ between estrous cycle stages. These results suggest that the estrous cycle stage should be accounted for when measuring in vivo arterial stiffness." @default.
• W4306194414 created "2022-10-14" @default.
• W4306194414 creator A5034450283 @default.
• W4306194414 creator A5055343964 @default.
• W4306194414 creator A5066870500 @default.
• W4306194414 creator A5068571805 @default.
• W4306194414 creator A5070478426 @default.
• W4306194414 creator A5072061963 @default.
• W4306194414 creator A5088339778 @default.
• W4306194414 date "2022-12-01" @default.
• W4306194414 modified "2023-10-11" @default.
• W4306194414 title "In vivo arterial stiffness, but not isolated artery endothelial function, varies with the mouse estrous cycle" @default.
• W4306194414 cites W1514783140 @default.
• W4306194414 cites W1941192198 @default.
• W4306194414 cites W1948854550 @default.
• W4306194414 cites W1970828440 @default.
• W4306194414 cites W1974345886 @default.
• W4306194414 cites W1978752207 @default.
• W4306194414 cites W1982471919 @default.
• W4306194414 cites W1983126942 @default.
• W4306194414 cites W1984377915 @default.
• W4306194414 cites W1985139791 @default.
• W4306194414 cites W1991455388 @default.
• W4306194414 cites W1997603886 @default.
• W4306194414 cites W2013117639 @default.
• W4306194414 cites W2015473903 @default.
• W4306194414 cites W2017716389 @default.
• W4306194414 cites W2022822304 @default.
• W4306194414 cites W2027431314 @default.
• W4306194414 cites W2028084760 @default.
• W4306194414 cites W2030701654 @default.
• W4306194414 cites W2033313708 @default.
• W4306194414 cites W2033504349 @default.
• W4306194414 cites W2043223954 @default.
• W4306194414 cites W2043335534 @default.
• W4306194414 cites W2049202299 @default.
• W4306194414 cites W2051678082 @default.
• W4306194414 cites W2063712126 @default.
• W4306194414 cites W2082130856 @default.
• W4306194414 cites W2096022216 @default.
• W4306194414 cites W2099763626 @default.
• W4306194414 cites W2101178259 @default.
• W4306194414 cites W2101650642 @default.
• W4306194414 cites W2110922412 @default.
• W4306194414 cites W2110989737 @default.
• W4306194414 cites W2116024161 @default.
• W4306194414 cites W2116832131 @default.
• W4306194414 cites W2118197078 @default.
• W4306194414 cites W2123175299 @default.
• W4306194414 cites W2129878006 @default.
• W4306194414 cites W2132493667 @default.
• W4306194414 cites W2139088926 @default.
• W4306194414 cites W2139129761 @default.
• W4306194414 cites W2143932527 @default.
• W4306194414 cites W2146633512 @default.
• W4306194414 cites W2151895436 @default.
• W4306194414 cites W2154472114 @default.
• W4306194414 cites W2160377398 @default.
• W4306194414 cites W2160969949 @default.
• W4306194414 cites W2167671333 @default.
• W4306194414 cites W2170472444 @default.
• W4306194414 cites W2171174161 @default.
• W4306194414 cites W2316473644 @default.
• W4306194414 cites W2357544716 @default.
• W4306194414 cites W2394724269 @default.
• W4306194414 cites W2396382574 @default.
• W4306194414 cites W2417238342 @default.
• W4306194414 cites W2766307829 @default.
• W4306194414 cites W2807620615 @default.
• W4306194414 cites W2914371319 @default.
• W4306194414 cites W2942012724 @default.
• W4306194414 cites W2963481938 @default.
• W4306194414 cites W2967409093 @default.
• W4306194414 cites W2971164718 @default.
• W4306194414 cites W3012573213 @default.
• W4306194414 cites W3035535990 @default.
• W4306194414 cites W3038731311 @default.
• W4306194414 cites W3085724661 @default.
• W4306194414 cites W3093009228 @default.
• W4306194414 cites W3126956649 @default.
• W4306194414 cites W3165672341 @default.
• W4306194414 cites W3179955615 @default.
• W4306194414 cites W3185253888 @default.
• W4306194414 cites W3200300548 @default.
• W4306194414 cites W3205438321 @default.
• W4306194414 cites W4226077547 @default.
• W4306194414 cites W4253410832 @default.
• W4306194414 cites W4283466458 @default.
• W4306194414 cites W318965623 @default.
• W4306194414 doi "https://doi.org/10.1152/ajpheart.00369.2022" @default.
• W4306194414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36240435" @default.
• W4306194414 hasPublicationYear "2022" @default.
• W4306194414 type Work @default.
• W4306194414 citedByCount "6" @default.
• W4306194414 countsByYear W43061944142023 @default.
• W4306194414 crossrefType "journal-article" @default.
• W4306194414 hasAuthorship W4306194414A5034450283 @default.
• W4306194414 hasAuthorship W4306194414A5055343964 @default.

• next