Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306247210> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4306247210 endingPage "e31166" @default.
- W4306247210 startingPage "e31166" @default.
- W4306247210 abstract "Diltiazem (DZ) is widely prescribed in transplant recipients because of its drug-drug interactions with calcineurin inhibitors (CNI). However, these interactions have been primarily investigated in renal transplantation, and data regarding the long-term efficacy and safety of DZ in orthotopic heart transplantation (OHT) are still sparse. Our study aimed to elucidate the extent to which the co-prescription of DZ reduces the dose required to maintain adequate blood levels of cyclosporine A (CsA) and the resulting effect on morbidity and mortality in OHT recipients. We performed a retrospective single-center analysis of OHT recipients on a long-term immunosuppressive regimen based on CsA and mycophenolate mofetil (MMF). The study population consisted of 95 adult OHT recipients with a mean follow-up of 15.8 ± 6.7 years. DZ was co-prescribed in 39 subjects (41.1%) and was associated with a 28.6% reduction of the mean CsA daily dose ( P < .001). Patients on DZ had less frequent rejection episodes ( P = .002), better renal function ( P = .009) and a lower rate of end-stage renal disease ( P = .008). Additionally, they developed later cardiac allograft vasculopathy (CAV). We observed no prognostic relevance of DZ co-prescription in univariate and multivariate Cox-regression analyses. In addition to reducing the CsA dose required to maintain adequate blood through levels, DZ may have nephroprotective properties in OHT. The co-administration of DZ may decelerate the development of CAV and reduce the frequency of the rejection episodes. However, the beneficial influence on morbidity has no impact on mortality." @default.
- W4306247210 created "2022-10-15" @default.
- W4306247210 creator A5001543713 @default.
- W4306247210 creator A5007945519 @default.
- W4306247210 creator A5013761152 @default.
- W4306247210 creator A5070708677 @default.
- W4306247210 date "2022-10-14" @default.
- W4306247210 modified "2023-10-14" @default.
- W4306247210 title "Diltiazem as a cyclosporine A-sparing agent in heart transplantation: Benefits beyond dose reduction" @default.
- W4306247210 cites W1592567691 @default.
- W4306247210 cites W1977703774 @default.
- W4306247210 cites W2025912103 @default.
- W4306247210 cites W2047928147 @default.
- W4306247210 cites W2084592920 @default.
- W4306247210 cites W2089953824 @default.
- W4306247210 cites W2108128781 @default.
- W4306247210 cites W2125018526 @default.
- W4306247210 cites W2136728326 @default.
- W4306247210 cites W2140327909 @default.
- W4306247210 cites W2165197739 @default.
- W4306247210 cites W2336501769 @default.
- W4306247210 cites W2401439852 @default.
- W4306247210 cites W2518602619 @default.
- W4306247210 cites W2919958548 @default.
- W4306247210 cites W3005764013 @default.
- W4306247210 cites W4226183233 @default.
- W4306247210 doi "https://doi.org/10.1097/md.0000000000031166" @default.
- W4306247210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36254022" @default.
- W4306247210 hasPublicationYear "2022" @default.
- W4306247210 type Work @default.
- W4306247210 citedByCount "0" @default.
- W4306247210 crossrefType "journal-article" @default.
- W4306247210 hasAuthorship W4306247210A5001543713 @default.
- W4306247210 hasAuthorship W4306247210A5007945519 @default.
- W4306247210 hasAuthorship W4306247210A5013761152 @default.
- W4306247210 hasAuthorship W4306247210A5070708677 @default.
- W4306247210 hasBestOaLocation W43062472101 @default.
- W4306247210 hasConcept C126322002 @default.
- W4306247210 hasConcept C126894567 @default.
- W4306247210 hasConcept C128057223 @default.
- W4306247210 hasConcept C159641895 @default.
- W4306247210 hasConcept C164705383 @default.
- W4306247210 hasConcept C2776741139 @default.
- W4306247210 hasConcept C2778849806 @default.
- W4306247210 hasConcept C2781413609 @default.
- W4306247210 hasConcept C2908647359 @default.
- W4306247210 hasConcept C2911091166 @default.
- W4306247210 hasConcept C519063684 @default.
- W4306247210 hasConcept C71924100 @default.
- W4306247210 hasConcept C98274493 @default.
- W4306247210 hasConcept C99454951 @default.
- W4306247210 hasConceptScore W4306247210C126322002 @default.
- W4306247210 hasConceptScore W4306247210C126894567 @default.
- W4306247210 hasConceptScore W4306247210C128057223 @default.
- W4306247210 hasConceptScore W4306247210C159641895 @default.
- W4306247210 hasConceptScore W4306247210C164705383 @default.
- W4306247210 hasConceptScore W4306247210C2776741139 @default.
- W4306247210 hasConceptScore W4306247210C2778849806 @default.
- W4306247210 hasConceptScore W4306247210C2781413609 @default.
- W4306247210 hasConceptScore W4306247210C2908647359 @default.
- W4306247210 hasConceptScore W4306247210C2911091166 @default.
- W4306247210 hasConceptScore W4306247210C519063684 @default.
- W4306247210 hasConceptScore W4306247210C71924100 @default.
- W4306247210 hasConceptScore W4306247210C98274493 @default.
- W4306247210 hasConceptScore W4306247210C99454951 @default.
- W4306247210 hasIssue "41" @default.
- W4306247210 hasLocation W43062472101 @default.
- W4306247210 hasLocation W43062472102 @default.
- W4306247210 hasLocation W43062472103 @default.
- W4306247210 hasLocation W43062472104 @default.
- W4306247210 hasOpenAccess W4306247210 @default.
- W4306247210 hasPrimaryLocation W43062472101 @default.
- W4306247210 hasRelatedWork W1997245814 @default.
- W4306247210 hasRelatedWork W2022636322 @default.
- W4306247210 hasRelatedWork W2053110560 @default.
- W4306247210 hasRelatedWork W2055330772 @default.
- W4306247210 hasRelatedWork W2071302339 @default.
- W4306247210 hasRelatedWork W2079720186 @default.
- W4306247210 hasRelatedWork W2148950609 @default.
- W4306247210 hasRelatedWork W2399770488 @default.
- W4306247210 hasRelatedWork W2548660892 @default.
- W4306247210 hasRelatedWork W4205643111 @default.
- W4306247210 hasVolume "101" @default.
- W4306247210 isParatext "false" @default.
- W4306247210 isRetracted "false" @default.
- W4306247210 workType "article" @default.