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• W4306248156 abstract "Pancreatic ductal adenocarcinoma (PDA) is associated with activation of WNT signaling. Whether this signaling pathway regulates the tumor microenvironment has remained unexplored. Through single-cell RNA sequencing of human pancreatic cancer, we discovered that tumor-infiltrating CD4+ T cells express TCF7, encoding for the transcription factor TCF1. We conditionally inactivated Tcf7 in CD4 expressing T cells in a mouse model of pancreatic cancer and observed changes in the tumor immune microenvironment, including more CD8+ T cells and fewer regulatory T cells, but also compensatory upregulation of PD-L1. We then used a clinically available inhibitor of Porcupine, a key component of WNT signaling, and observed similar reprogramming of the immune response. WNT signaling inhibition has limited therapeutic window due to toxicity, and PD-L1 blockade has been ineffective in PDA. Here, we show that combination targeting reduces pancreatic cancer growth in an experimental model and might benefit the treatment of pancreatic cancer." @default.
• W4306248156 created "2022-10-15" @default.
• W4306248156 creator A5011640261 @default.
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• W4306248156 date "2022-10-14" @default.
• W4306248156 modified "2023-10-18" @default.
• W4306248156 title "WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer" @default.
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• W4306248156 cites W121009447 @default.
• W4306248156 cites W1491270159 @default.
• W4306248156 cites W1498931318 @default.
• W4306248156 cites W1856892620 @default.
• W4306248156 cites W1955427151 @default.
• W4306248156 cites W1992995822 @default.
• W4306248156 cites W1994029539 @default.
• W4306248156 cites W1994928797 @default.
• W4306248156 cites W2002355858 @default.
• W4306248156 cites W2010916968 @default.
• W4306248156 cites W2016732129 @default.
• W4306248156 cites W2031130467 @default.
• W4306248156 cites W2034893372 @default.
• W4306248156 cites W2057718072 @default.
• W4306248156 cites W2066135299 @default.
• W4306248156 cites W2075819066 @default.
• W4306248156 cites W2085605492 @default.
• W4306248156 cites W2086152184 @default.
• W4306248156 cites W2086834665 @default.
• W4306248156 cites W2098036848 @default.
• W4306248156 cites W2099023480 @default.
• W4306248156 cites W2100519108 @default.
• W4306248156 cites W2101653483 @default.
• W4306248156 cites W2102532180 @default.
• W4306248156 cites W2109420862 @default.
• W4306248156 cites W2123911142 @default.
• W4306248156 cites W2124677800 @default.
• W4306248156 cites W2133267962 @default.
• W4306248156 cites W2138155367 @default.
• W4306248156 cites W2139909490 @default.
• W4306248156 cites W2144796561 @default.
• W4306248156 cites W2148054025 @default.
• W4306248156 cites W2153042210 @default.
• W4306248156 cites W2153243639 @default.
• W4306248156 cites W2158232223 @default.
• W4306248156 cites W2158819616 @default.
• W4306248156 cites W2166178545 @default.
• W4306248156 cites W2185456083 @default.
• W4306248156 cites W2282980403 @default.
• W4306248156 cites W2322802697 @default.
• W4306248156 cites W2461513545 @default.
• W4306248156 cites W2507863505 @default.
• W4306248156 cites W2510426677 @default.
• W4306248156 cites W2553481980 @default.
• W4306248156 cites W2554708126 @default.
• W4306248156 cites W2587980604 @default.
• W4306248156 cites W2601014096 @default.
• W4306248156 cites W2621361823 @default.
• W4306248156 cites W2630941289 @default.
• W4306248156 cites W2736312236 @default.
• W4306248156 cites W2782949806 @default.
• W4306248156 cites W2794480084 @default.
• W4306248156 cites W2795151933 @default.
• W4306248156 cites W2799466853 @default.
• W4306248156 cites W2801309958 @default.
• W4306248156 cites W2801967759 @default.
• W4306248156 cites W2803586435 @default.
• W4306248156 cites W2811471643 @default.
• W4306248156 cites W2891660187 @default.
• W4306248156 cites W2899145148 @default.
• W4306248156 cites W2901891025 @default.
• W4306248156 cites W2909312563 @default.
• W4306248156 cites W2909486828 @default.
• W4306248156 cites W2911745810 @default.
• W4306248156 cites W2946302521 @default.
• W4306248156 cites W2949177718 @default.
• W4306248156 cites W2971398301 @default.
• W4306248156 cites W2972083722 @default.
• W4306248156 cites W2992247151 @default.
• W4306248156 cites W3000274143 @default.
• W4306248156 cites W3011819195 @default.
• W4306248156 cites W3030994291 @default.
• W4306248156 cites W3095442910 @default.
• W4306248156 cites W3135613078 @default.
• W4306248156 cites W3139435946 @default.
• W4306248156 cites W3141198694 @default.
• W4306248156 cites W3156796720 @default.
• W4306248156 cites W3159253529 @default.
• W4306248156 cites W3167004947 @default.
• W4306248156 cites W3185664408 @default.
• W4306248156 cites W3187894809 @default.
• W4306248156 cites W3193140392 @default.

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