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- W4306250011 abstract "Abstract Context Exogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain. Objective We tested the hypothesis that administration of the ketone body β-hydroxybutyrate (βOHB) acutely increases insulin sensitivity via feedback suppression of circulating free fatty acid (FFA) levels. Methods In a randomized, single-blinded crossover design, 8 healthy men were studied twice with a growth hormone (GH) infusion to induce lipolysis in combination with infusion of either βOHB or saline. Each study day comprised a basal period and a hyperinsulinemic-euglycemic clamp combined with a glucose tracer and adipose tissue and skeletal muscle biopsies. Results βOHB administration profoundly suppressed FFA levels concomitantly with a significant increase in glucose disposal and energy expenditure. This was accompanied by a many-fold increase in skeletal muscle content of both βOHB and its derivative acetoacetate. Conclusion Our data unravel an insulin-sensitizing effect of βOHB, which we suggest is mediated by concomitant suppression of lipolysis." @default.
- W4306250011 created "2022-10-15" @default.
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- W4306250011 date "2022-10-14" @default.
- W4306250011 modified "2023-10-16" @default.
- W4306250011 title "Ketone Body Infusion Abrogates Growth Hormone–Induced Lipolysis and Insulin Resistance" @default.
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- W4306250011 doi "https://doi.org/10.1210/clinem/dgac595" @default.
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