FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306250039> ?p ?o ?g. }

• W4306250039 endingPage "530" @default.
• W4306250039 startingPage "517" @default.
• W4306250039 abstract "The genome of the filarial worm Brugia malayi was one of the first parasitic nematode genomes to be sequenced, over a decade ago. Since then, improved technology has facilitated sequencing of the genomes and transcriptomes of many more filarial species and of their Wolbachia endosymbiont. It is now possible to identify genes and gene families that are present in filariae, to compare across species to identify gene gain and loss and to identify in which developmental stages specific genes are expressed. However, functional studies have lagged behind progress in genome sequencing. Some genes are conserved across the nematode phylum, and functional information can be gained from the model nematode Caenorhabditis elegans . However, many genes in filarial nematodes are novel, and direct manipulation in the parasite is required to verify their function. Here we review successes to date with RNA interference (RNAi) technology and the phenotypes observed in a variety of filarial species and life cycle stages following RNAi by soaking. In addition to success with gene knock-down, significant progress has been made in transfection methodology allowing the expression of transgenes in filarial worms, holding promise for determining spatial and temporal gene expression patterns. CRISPR-Cas9 knockout has proved effective in C. elegans and in the parasitic nematode Strongyloides and, building upon the success of transfection, has the potential to revolutionize functional genomics in filarial nematodes. Complementing these technologies are improvements in the in vitro culture of filarial species to enhance development, which is important for phenotypic screening. Together, the application of these technologies holds promise for advancing knowledge of filarial gene function." @default.
• W4306250039 created "2022-10-15" @default.
• W4306250039 creator A5082443574 @default.
• W4306250039 creator A5089634063 @default.
• W4306250039 date "2022-10-14" @default.
• W4306250039 modified "2023-09-26" @default.
• W4306250039 title "Functional Genomics of Filariae" @default.
• W4306250039 cites W1727004971 @default.
• W4306250039 cites W1992109253 @default.
• W4306250039 cites W1993891864 @default.
• W4306250039 cites W1994989080 @default.
• W4306250039 cites W1998491115 @default.
• W4306250039 cites W1999174789 @default.
• W4306250039 cites W2014651954 @default.
• W4306250039 cites W2017273060 @default.
• W4306250039 cites W2020790954 @default.
• W4306250039 cites W2021752373 @default.
• W4306250039 cites W2028933485 @default.
• W4306250039 cites W2029889310 @default.
• W4306250039 cites W2031249182 @default.
• W4306250039 cites W2034685592 @default.
• W4306250039 cites W2046224798 @default.
• W4306250039 cites W2050597181 @default.
• W4306250039 cites W2058538505 @default.
• W4306250039 cites W2068113244 @default.
• W4306250039 cites W2071442384 @default.
• W4306250039 cites W2087256232 @default.
• W4306250039 cites W2092726462 @default.
• W4306250039 cites W2101128429 @default.
• W4306250039 cites W2107905656 @default.
• W4306250039 cites W2109160513 @default.
• W4306250039 cites W2111853426 @default.
• W4306250039 cites W2125198788 @default.
• W4306250039 cites W2127192075 @default.
• W4306250039 cites W2132674511 @default.
• W4306250039 cites W2144008452 @default.
• W4306250039 cites W2147202122 @default.
• W4306250039 cites W2149210551 @default.
• W4306250039 cites W2153023488 @default.
• W4306250039 cites W2154326606 @default.
• W4306250039 cites W2155271571 @default.
• W4306250039 cites W2180284072 @default.
• W4306250039 cites W2263236687 @default.
• W4306250039 cites W2319289595 @default.
• W4306250039 cites W2333256324 @default.
• W4306250039 cites W2411997720 @default.
• W4306250039 cites W2460413827 @default.
• W4306250039 cites W2552031419 @default.
• W4306250039 cites W2554876023 @default.
• W4306250039 cites W2578032984 @default.
• W4306250039 cites W2581013938 @default.
• W4306250039 cites W2600638053 @default.
• W4306250039 cites W2612453616 @default.
• W4306250039 cites W2620003184 @default.
• W4306250039 cites W2747545374 @default.
• W4306250039 cites W2760861874 @default.
• W4306250039 cites W2762135737 @default.
• W4306250039 cites W2780728213 @default.
• W4306250039 cites W2786675584 @default.
• W4306250039 cites W2804464934 @default.
• W4306250039 cites W2910424110 @default.
• W4306250039 cites W2951131794 @default.
• W4306250039 cites W2952876664 @default.
• W4306250039 cites W2955140314 @default.
• W4306250039 cites W2972184354 @default.
• W4306250039 cites W2976320998 @default.
• W4306250039 doi "https://doi.org/10.1002/9783527823413.ch20" @default.
• W4306250039 hasPublicationYear "2022" @default.
• W4306250039 type Work @default.
• W4306250039 citedByCount "1" @default.
• W4306250039 countsByYear W43062500392022 @default.
• W4306250039 crossrefType "other" @default.
• W4306250039 hasAuthorship W4306250039A5082443574 @default.
• W4306250039 hasAuthorship W4306250039A5089634063 @default.
• W4306250039 hasConcept C104317684 @default.
• W4306250039 hasConcept C141231307 @default.
• W4306250039 hasConcept C161078062 @default.
• W4306250039 hasConcept C165901193 @default.
• W4306250039 hasConcept C166703698 @default.
• W4306250039 hasConcept C189206191 @default.
• W4306250039 hasConcept C2775848585 @default.
• W4306250039 hasConcept C2777629521 @default.
• W4306250039 hasConcept C2778944004 @default.
• W4306250039 hasConcept C2779356413 @default.
• W4306250039 hasConcept C54355233 @default.
• W4306250039 hasConcept C67705224 @default.
• W4306250039 hasConcept C70721500 @default.
• W4306250039 hasConcept C86803240 @default.
• W4306250039 hasConcept C90856448 @default.
• W4306250039 hasConcept C98108389 @default.
• W4306250039 hasConceptScore W4306250039C104317684 @default.
• W4306250039 hasConceptScore W4306250039C141231307 @default.
• W4306250039 hasConceptScore W4306250039C161078062 @default.
• W4306250039 hasConceptScore W4306250039C165901193 @default.
• W4306250039 hasConceptScore W4306250039C166703698 @default.
• W4306250039 hasConceptScore W4306250039C189206191 @default.
• W4306250039 hasConceptScore W4306250039C2775848585 @default.
• W4306250039 hasConceptScore W4306250039C2777629521 @default.

• next