Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306252020> ?p ?o ?g. }
- W4306252020 endingPage "109304" @default.
- W4306252020 startingPage "109304" @default.
- W4306252020 abstract "Cancer immunotherapy with immune checkpoint inhibitors has achieved unprecedented success in cancer treatment; However, only a subset of patients achieved clinical benefit from this treatment, underscoring the urgent need to identify new strategies to enhance the clinical efficacy of immune checkpoint inhibitors. Given the essential role of innate immunity in cancer immune surveillance, tremendous effort has been focused on the innate immune pathways that can be pharmacologically modulated to improve the clinical outcome of checkpoint inhibitors. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway plays essential roles in host defense against cancers. Activation of the cGAS-STING signaling pathway induces the expression of type I interferons and proinflammatory cytokines, culminating in promotion of a robust adaptive antitumor immunity. As part of this innate immune signaling pathway, STING is ubiquitously expressed in immune and nonimmune cells. STING activation has been demonstrated to propagate the cancer immunity cycle, remodel the tumor microenvironment, and ultimately eliminate tumor cells. The immunomodulatory roles of STING enable it to be an appealing target for cancer immunotherapy. As such, STING agonists that are capable of triggering antitumor immune responses have been developed in recent years, and several of them have advanced into clinical trials. In this review, we first give an overview on the STING signaling pathway, then dissect the roles of STING activation in different steps of the cancer immunity cycle and finally discuss the development of STING agonists as well as challenges with STING activation, with the potential to make cancer immunotherapy with STING agonists more effective." @default.
- W4306252020 created "2022-10-15" @default.
- W4306252020 creator A5004858645 @default.
- W4306252020 creator A5022160487 @default.
- W4306252020 creator A5022602956 @default.
- W4306252020 creator A5030978002 @default.
- W4306252020 creator A5033799280 @default.
- W4306252020 creator A5072820185 @default.
- W4306252020 creator A5079849954 @default.
- W4306252020 date "2022-12-01" @default.
- W4306252020 modified "2023-10-16" @default.
- W4306252020 title "Targeting STING for cancer immunotherapy: From mechanisms to translation" @default.
- W4306252020 cites W1124150750 @default.
- W4306252020 cites W1559117436 @default.
- W4306252020 cites W1608778557 @default.
- W4306252020 cites W1611944043 @default.
- W4306252020 cites W1630358515 @default.
- W4306252020 cites W1866003637 @default.
- W4306252020 cites W1898887656 @default.
- W4306252020 cites W1905337938 @default.
- W4306252020 cites W1968811042 @default.
- W4306252020 cites W1975089377 @default.
- W4306252020 cites W1983487014 @default.
- W4306252020 cites W1984539398 @default.
- W4306252020 cites W1993860509 @default.
- W4306252020 cites W1994826332 @default.
- W4306252020 cites W1994993231 @default.
- W4306252020 cites W2000179708 @default.
- W4306252020 cites W2016263096 @default.
- W4306252020 cites W2020210109 @default.
- W4306252020 cites W2026134797 @default.
- W4306252020 cites W2027040310 @default.
- W4306252020 cites W2027163190 @default.
- W4306252020 cites W2028792773 @default.
- W4306252020 cites W2032841298 @default.
- W4306252020 cites W2035442859 @default.
- W4306252020 cites W2035858672 @default.
- W4306252020 cites W2041345682 @default.
- W4306252020 cites W2059020146 @default.
- W4306252020 cites W2066586758 @default.
- W4306252020 cites W2066818317 @default.
- W4306252020 cites W2083147016 @default.
- W4306252020 cites W2085192138 @default.
- W4306252020 cites W2091144643 @default.
- W4306252020 cites W2099610218 @default.
- W4306252020 cites W2111512928 @default.
- W4306252020 cites W2119864130 @default.
- W4306252020 cites W2132413371 @default.
- W4306252020 cites W2133402546 @default.
- W4306252020 cites W2154171253 @default.
- W4306252020 cites W2155358182 @default.
- W4306252020 cites W2158542519 @default.
- W4306252020 cites W2170295495 @default.
- W4306252020 cites W2171745628 @default.
- W4306252020 cites W2173816666 @default.
- W4306252020 cites W2220279767 @default.
- W4306252020 cites W2237126693 @default.
- W4306252020 cites W2237797200 @default.
- W4306252020 cites W2296705508 @default.
- W4306252020 cites W2402433991 @default.
- W4306252020 cites W2417489976 @default.
- W4306252020 cites W2516091650 @default.
- W4306252020 cites W2522054472 @default.
- W4306252020 cites W2579136823 @default.
- W4306252020 cites W2579137335 @default.
- W4306252020 cites W2580868078 @default.
- W4306252020 cites W2586653152 @default.
- W4306252020 cites W2626019299 @default.
- W4306252020 cites W2750976328 @default.
- W4306252020 cites W2754087313 @default.
- W4306252020 cites W2766014141 @default.
- W4306252020 cites W2766860384 @default.
- W4306252020 cites W2770884891 @default.
- W4306252020 cites W2776123645 @default.
- W4306252020 cites W2782762980 @default.
- W4306252020 cites W2791483720 @default.
- W4306252020 cites W2800226737 @default.
- W4306252020 cites W2802206159 @default.
- W4306252020 cites W2807798312 @default.
- W4306252020 cites W2854081253 @default.
- W4306252020 cites W2892170438 @default.
- W4306252020 cites W2900220188 @default.
- W4306252020 cites W2905027070 @default.
- W4306252020 cites W2906160139 @default.
- W4306252020 cites W2907564726 @default.
- W4306252020 cites W2909554490 @default.
- W4306252020 cites W2911294141 @default.
- W4306252020 cites W2916344645 @default.
- W4306252020 cites W2917427311 @default.
- W4306252020 cites W2919896467 @default.
- W4306252020 cites W2922049377 @default.
- W4306252020 cites W2923545753 @default.
- W4306252020 cites W2937379640 @default.
- W4306252020 cites W2947021030 @default.
- W4306252020 cites W2959930806 @default.
- W4306252020 cites W2963305393 @default.
- W4306252020 cites W2966261467 @default.
- W4306252020 cites W2970843395 @default.