FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306253166> ?p ?o ?g. }

• W4306253166 abstract "Alterations in the global brain gray matter volume (gGMV) and global functional connectivity density (gFCD) play a pivotal role in the cognitive impairment and further deterioration in schizophrenia. This study aimed to assess the correlation between alterations in the gGMV and gFCD at baseline (ΔgGMV and ΔgFCD), and the subsequent alterations of cognitive function in schizophrenia patients after 2-year antipsychotic treatment. Global-brain magnetic resonance imaging scans were acquired from 877 drug-naïve, first-episode schizophrenia patients at baseline and after two years of antipsychotic treatment with adequate dosage and duration, and 200 healthy controls. According to ΔgGMV at baseline, schizophrenia patients were divided into mild, moderate, and severe alteration groups. The MATRICS consensus cognitive battery and Global Deficit Score (GDS) were used to assess cognitive impairment. We found that ΔgGMV and ΔgFCD at baseline were significantly correlated with the severity of the cognitive deterioration (ΔGDS). The correlation coefficient indicated a significant positive correlation between baseline ΔgFCD and subsequent cognitive deterioration, with a relatively stronger relation in the mild alteration group (r = 0.31). In addition, there was a significant positive correlation between baseline ΔgGMV and subsequent cognitive deterioration, with a stronger relation in the moderate and severe alteration groups (r = 0.303; r = 0.302, respectively). Our results showed that ΔgGMV and ΔgFCD are correlated with the severity of cognitive deterioration after completion of a 2-year antipsychotic treatment in schizophrenia patients. These findings suggest that baseline alterations in gGMV and gFCD hold potential for predicting subsequent cognitive decline in schizophrenia." @default.
• W4306253166 created "2022-10-15" @default.
• W4306253166 creator A5007877698 @default.
• W4306253166 creator A5014980515 @default.
• W4306253166 creator A5026704485 @default.
• W4306253166 creator A5027486295 @default.
• W4306253166 creator A5040799766 @default.
• W4306253166 creator A5042947574 @default.
• W4306253166 creator A5053281055 @default.
• W4306253166 creator A5058508058 @default.
• W4306253166 creator A5061604331 @default.
• W4306253166 creator A5067159163 @default.
• W4306253166 creator A5070235896 @default.
• W4306253166 creator A5087792260 @default.
• W4306253166 date "2022-10-14" @default.
• W4306253166 modified "2023-09-26" @default.
• W4306253166 title "Baseline global brain structural and functional alterations at the time of symptom onset can predict subsequent cognitive deterioration in drug-naïve first-episode schizophrenia patients: Evidence from a follow-up study" @default.
• W4306253166 cites W1487091206 @default.
• W4306253166 cites W1968864736 @default.
• W4306253166 cites W1973029807 @default.
• W4306253166 cites W1987599891 @default.
• W4306253166 cites W1988581447 @default.
• W4306253166 cites W1988694821 @default.
• W4306253166 cites W1990134753 @default.
• W4306253166 cites W1995362640 @default.
• W4306253166 cites W1998292861 @default.
• W4306253166 cites W1999522048 @default.
• W4306253166 cites W2004469093 @default.
• W4306253166 cites W2019581335 @default.
• W4306253166 cites W2024078112 @default.
• W4306253166 cites W2035200063 @default.
• W4306253166 cites W2037617443 @default.
• W4306253166 cites W2039144322 @default.
• W4306253166 cites W2049689895 @default.
• W4306253166 cites W2050067518 @default.
• W4306253166 cites W2053874763 @default.
• W4306253166 cites W2081893917 @default.
• W4306253166 cites W2094767250 @default.
• W4306253166 cites W2098337487 @default.
• W4306253166 cites W2103543063 @default.
• W4306253166 cites W2122636740 @default.
• W4306253166 cites W2138400597 @default.
• W4306253166 cites W2139390659 @default.
• W4306253166 cites W2144686754 @default.
• W4306253166 cites W2146809691 @default.
• W4306253166 cites W2155298532 @default.
• W4306253166 cites W2160022744 @default.
• W4306253166 cites W2161230459 @default.
• W4306253166 cites W2165955750 @default.
• W4306253166 cites W2221741158 @default.
• W4306253166 cites W2298643181 @default.
• W4306253166 cites W2317070629 @default.
• W4306253166 cites W2317320523 @default.
• W4306253166 cites W2320066895 @default.
• W4306253166 cites W2584678119 @default.
• W4306253166 cites W2595100001 @default.
• W4306253166 cites W2597348720 @default.
• W4306253166 cites W2605397563 @default.
• W4306253166 cites W2616659710 @default.
• W4306253166 cites W2623598950 @default.
• W4306253166 cites W2688630157 @default.
• W4306253166 cites W2735511385 @default.
• W4306253166 cites W2756015896 @default.
• W4306253166 cites W2757652074 @default.
• W4306253166 cites W2758555533 @default.
• W4306253166 cites W2770106029 @default.
• W4306253166 cites W2779626126 @default.
• W4306253166 cites W2786092901 @default.
• W4306253166 cites W2806887272 @default.
• W4306253166 cites W2883206457 @default.
• W4306253166 cites W2884367318 @default.
• W4306253166 cites W2892233392 @default.
• W4306253166 cites W2897341379 @default.
• W4306253166 cites W2902303283 @default.
• W4306253166 cites W2914373113 @default.
• W4306253166 cites W2914429463 @default.
• W4306253166 cites W2924345844 @default.
• W4306253166 cites W2935855056 @default.
• W4306253166 cites W2944124487 @default.
• W4306253166 cites W2947957507 @default.
• W4306253166 cites W2952555877 @default.
• W4306253166 cites W2963234282 @default.
• W4306253166 cites W2963781994 @default.
• W4306253166 cites W2972372011 @default.
• W4306253166 cites W2982479584 @default.
• W4306253166 cites W2982685163 @default.
• W4306253166 cites W2988009582 @default.
• W4306253166 cites W2990836270 @default.
• W4306253166 cites W3002563918 @default.
• W4306253166 cites W3006849857 @default.
• W4306253166 cites W3009127448 @default.
• W4306253166 cites W3017013151 @default.
• W4306253166 cites W3019591675 @default.
• W4306253166 cites W3031273217 @default.
• W4306253166 cites W3041137810 @default.
• W4306253166 cites W3047473122 @default.
• W4306253166 cites W3082177965 @default.
• W4306253166 cites W3093720752 @default.
• W4306253166 cites W3096617038 @default.
• W4306253166 cites W3110944216 @default.

• next