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• W4306254908 abstract "Abstract Differential speeds in biochemical reactions have been proposed to be responsible for the differences in developmental tempo between mice and humans. However, the underlying mechanism controlling the species-specific kinetics remains to be determined. Using in vitro differentiation of pluripotent stem cells, we recapitulated the segmentation clocks of diverse mammalian species varying in body weight and taxa: marmoset, rabbit, cattle and rhinoceros. Together with the mouse and human, the segmentation clock periods of the six species did not scale with the animal body weight, but were rather grouped according to phylogeny. The biochemical kinetics of the core clock gene HES7 displayed clear scaling with the species-specific segmentation clock period. However, the cellular metabolic rates did not show an evident correlation. Instead, genes involving biochemical reactions showed an expression pattern that scales with the segmentation clock period. Altogether, our stem cell zoo uncovered general scaling laws governing species-specific developmental tempo.*" @default.
• W4306254908 created "2022-10-15" @default.
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• W4306254908 date "2022-10-14" @default.
• W4306254908 modified "2023-09-28" @default.
• W4306254908 title "A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals" @default.
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• W4306254908 doi "https://doi.org/10.1101/2022.10.13.512072" @default.
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