Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306291384> ?p ?o ?g. }
- W4306291384 abstract "Total joint arthroplasty is a common surgical procedure resulting in improved quality of life; however, a leading cause of surgery failure is infection. Periprosthetic joint infections often involve biofilms, making treatment challenging. The metabolic state of pathogens in the joint space and mechanism of their tolerance to antibiotics and host defenses are not well understood. Thus, there is a critical need for increased understanding of the physiological state of pathogens in the joint space for development of improved treatment strategies toward better patient outcomes. Here, we present a quantitative, untargeted NMR-based metabolomics strategy for Pseudomonas aeruginosa suspended culture and biofilm phenotypes grown in bovine synovial fluid as a model system. Significant differences in metabolic pathways were found between the suspended culture and biofilm phenotypes including creatine, glutathione, alanine, and choline metabolism and the tricarboxylic acid cycle. We also identified 21 unique metabolites with the presence of P. aeruginosa in synovial fluid and one uniquely present with the biofilm phenotype in synovial fluid. If translatable in vivo, these unique metabolite and pathway differences have the potential for further development to serve as targets for P. aeruginosa and biofilm control in synovial fluid." @default.
- W4306291384 created "2022-10-15" @default.
- W4306291384 creator A5004512291 @default.
- W4306291384 creator A5009938955 @default.
- W4306291384 creator A5048086429 @default.
- W4306291384 creator A5050446611 @default.
- W4306291384 creator A5054186719 @default.
- W4306291384 creator A5083330988 @default.
- W4306291384 date "2022-10-15" @default.
- W4306291384 modified "2023-10-18" @default.
- W4306291384 title "Differential metabolism between biofilm and suspended Pseudomonas aeruginosa cultures in bovine synovial fluid by 2D NMR-based metabolomics" @default.
- W4306291384 cites W1682627357 @default.
- W4306291384 cites W1860527785 @default.
- W4306291384 cites W1889289315 @default.
- W4306291384 cites W1982185581 @default.
- W4306291384 cites W1999311026 @default.
- W4306291384 cites W2009868874 @default.
- W4306291384 cites W2018628774 @default.
- W4306291384 cites W2048361405 @default.
- W4306291384 cites W2073102164 @default.
- W4306291384 cites W2116502589 @default.
- W4306291384 cites W2121486625 @default.
- W4306291384 cites W2144440398 @default.
- W4306291384 cites W2152311269 @default.
- W4306291384 cites W2159010530 @default.
- W4306291384 cites W2159482845 @default.
- W4306291384 cites W2167583557 @default.
- W4306291384 cites W2168889580 @default.
- W4306291384 cites W2169821755 @default.
- W4306291384 cites W2276114740 @default.
- W4306291384 cites W2284192646 @default.
- W4306291384 cites W2403406371 @default.
- W4306291384 cites W2501621370 @default.
- W4306291384 cites W2508709614 @default.
- W4306291384 cites W2552014090 @default.
- W4306291384 cites W2555687332 @default.
- W4306291384 cites W2606945061 @default.
- W4306291384 cites W2674552166 @default.
- W4306291384 cites W2759147329 @default.
- W4306291384 cites W2777466035 @default.
- W4306291384 cites W2811505384 @default.
- W4306291384 cites W2896672523 @default.
- W4306291384 cites W2904606310 @default.
- W4306291384 cites W2908363006 @default.
- W4306291384 cites W2912957596 @default.
- W4306291384 cites W2913666085 @default.
- W4306291384 cites W2914785334 @default.
- W4306291384 cites W2938070949 @default.
- W4306291384 cites W2943246799 @default.
- W4306291384 cites W2946684000 @default.
- W4306291384 cites W2968709012 @default.
- W4306291384 cites W2975219453 @default.
- W4306291384 cites W2977870980 @default.
- W4306291384 cites W2982711351 @default.
- W4306291384 cites W2999338853 @default.
- W4306291384 cites W3004553650 @default.
- W4306291384 cites W3015722259 @default.
- W4306291384 cites W3029543049 @default.
- W4306291384 cites W3037320616 @default.
- W4306291384 cites W3044403033 @default.
- W4306291384 cites W3049628682 @default.
- W4306291384 cites W3113345802 @default.
- W4306291384 cites W3125157080 @default.
- W4306291384 cites W3131566806 @default.
- W4306291384 cites W3196571138 @default.
- W4306291384 cites W3200419434 @default.
- W4306291384 cites W3204713180 @default.
- W4306291384 cites W4212964820 @default.
- W4306291384 cites W4214498056 @default.
- W4306291384 cites W4281656633 @default.
- W4306291384 cites W4294216483 @default.
- W4306291384 doi "https://doi.org/10.1038/s41598-022-22127-x" @default.
- W4306291384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36243882" @default.
- W4306291384 hasPublicationYear "2022" @default.
- W4306291384 type Work @default.
- W4306291384 citedByCount "4" @default.
- W4306291384 countsByYear W43062913842023 @default.
- W4306291384 crossrefType "journal-article" @default.
- W4306291384 hasAuthorship W4306291384A5004512291 @default.
- W4306291384 hasAuthorship W4306291384A5009938955 @default.
- W4306291384 hasAuthorship W4306291384A5048086429 @default.
- W4306291384 hasAuthorship W4306291384A5050446611 @default.
- W4306291384 hasAuthorship W4306291384A5054186719 @default.
- W4306291384 hasAuthorship W4306291384A5083330988 @default.
- W4306291384 hasBestOaLocation W43062913841 @default.
- W4306291384 hasConcept C142724271 @default.
- W4306291384 hasConcept C185592680 @default.
- W4306291384 hasConcept C192989942 @default.
- W4306291384 hasConcept C204787440 @default.
- W4306291384 hasConcept C21565614 @default.
- W4306291384 hasConcept C2776164576 @default.
- W4306291384 hasConcept C2776268809 @default.
- W4306291384 hasConcept C2777477808 @default.
- W4306291384 hasConcept C2777637488 @default.
- W4306291384 hasConcept C2779663596 @default.
- W4306291384 hasConcept C3020332539 @default.
- W4306291384 hasConcept C501593827 @default.
- W4306291384 hasConcept C523546767 @default.
- W4306291384 hasConcept C54355233 @default.
- W4306291384 hasConcept C55493867 @default.