Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306291514> ?p ?o ?g. }
- W4306291514 endingPage "120435" @default.
- W4306291514 startingPage "120435" @default.
- W4306291514 abstract "Zearalenone (ZEA) is a mycotoxin with estrogen-like biological activity, which widely present in feed and raw materials, with strong reproductive system toxicity and a major threat to animal reproduction. Betulinic acid (BA) is a natural plant compound with antioxidant, anti-inflammatory and other pharmacological activities. However, the mechanism of ZEA-induced uterine injury and the protective effect of BA have not been reported. Our results show that ZEA could cause uterine histopathological damage and cellular ultrastructural damage, affecting the secretion of sex hormones, such as estradiol (E2) and progesterone (P4), and increase the mRNA and protein expression of estrogen receptor α (ERα). ZEA could inhibit the activities of catalase (CAT) and superoxide dismutase (SOD), increase the production of malondialdehyde (MDA) and reactive oxygen species (ROS), and cause uterine oxidative stress. Furthermore, ZEA affected the homeostasis of uterine cell proliferation and death by regulating the expression of proliferating cell nuclear antigen (PCNA) and activating the mitochondrial apoptotic pathway. ZEA-induced uterine injury might be related to the activation of p38/ERK MAPK signaling pathway. However, the regulatory effect of ZEA on the uterus was reversed after BA treatment. In conclusion, the uterus is an important target organ attacked by ZEA, and BA showed a good therapeutic effect." @default.
- W4306291514 created "2022-10-15" @default.
- W4306291514 creator A5000482353 @default.
- W4306291514 creator A5019785797 @default.
- W4306291514 creator A5032190373 @default.
- W4306291514 creator A5035316895 @default.
- W4306291514 creator A5047463829 @default.
- W4306291514 creator A5047487046 @default.
- W4306291514 creator A5047509842 @default.
- W4306291514 creator A5064317694 @default.
- W4306291514 creator A5070498614 @default.
- W4306291514 creator A5076026075 @default.
- W4306291514 creator A5083963070 @default.
- W4306291514 creator A5086775048 @default.
- W4306291514 creator A5088634717 @default.
- W4306291514 date "2023-01-01" @default.
- W4306291514 modified "2023-10-14" @default.
- W4306291514 title "Betulinic acid alleviates zearalenone-induced uterine injury in mice" @default.
- W4306291514 cites W116732461 @default.
- W4306291514 cites W1547736903 @default.
- W4306291514 cites W1977613766 @default.
- W4306291514 cites W2017735744 @default.
- W4306291514 cites W2020479941 @default.
- W4306291514 cites W2031110610 @default.
- W4306291514 cites W2066728004 @default.
- W4306291514 cites W2073575443 @default.
- W4306291514 cites W2076840083 @default.
- W4306291514 cites W2103513010 @default.
- W4306291514 cites W2117803941 @default.
- W4306291514 cites W2136295423 @default.
- W4306291514 cites W2156246789 @default.
- W4306291514 cites W2163308401 @default.
- W4306291514 cites W2166115982 @default.
- W4306291514 cites W2199221072 @default.
- W4306291514 cites W2335873537 @default.
- W4306291514 cites W2514021534 @default.
- W4306291514 cites W2610177764 @default.
- W4306291514 cites W2620765227 @default.
- W4306291514 cites W2751000264 @default.
- W4306291514 cites W2759567716 @default.
- W4306291514 cites W2766194804 @default.
- W4306291514 cites W2775039013 @default.
- W4306291514 cites W2789303190 @default.
- W4306291514 cites W2799342893 @default.
- W4306291514 cites W2802508001 @default.
- W4306291514 cites W2810719630 @default.
- W4306291514 cites W2886076351 @default.
- W4306291514 cites W2887917447 @default.
- W4306291514 cites W2888676896 @default.
- W4306291514 cites W2889203844 @default.
- W4306291514 cites W2922390929 @default.
- W4306291514 cites W2930908474 @default.
- W4306291514 cites W2956078079 @default.
- W4306291514 cites W2971157369 @default.
- W4306291514 cites W2990038057 @default.
- W4306291514 cites W3013726226 @default.
- W4306291514 cites W3033619070 @default.
- W4306291514 cites W3048144208 @default.
- W4306291514 cites W3080528769 @default.
- W4306291514 cites W3112929515 @default.
- W4306291514 cites W3119680760 @default.
- W4306291514 cites W3121939908 @default.
- W4306291514 cites W3139196573 @default.
- W4306291514 cites W3139768592 @default.
- W4306291514 cites W3168409627 @default.
- W4306291514 cites W3179587313 @default.
- W4306291514 cites W3197103660 @default.
- W4306291514 cites W3205718156 @default.
- W4306291514 cites W3213781095 @default.
- W4306291514 cites W4214503495 @default.
- W4306291514 cites W4220843351 @default.
- W4306291514 cites W4225165250 @default.
- W4306291514 cites W4281779520 @default.
- W4306291514 cites W3207837840 @default.
- W4306291514 doi "https://doi.org/10.1016/j.envpol.2022.120435" @default.
- W4306291514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36257561" @default.
- W4306291514 hasPublicationYear "2023" @default.
- W4306291514 type Work @default.
- W4306291514 citedByCount "2" @default.
- W4306291514 countsByYear W43062915142023 @default.
- W4306291514 crossrefType "journal-article" @default.
- W4306291514 hasAuthorship W4306291514A5000482353 @default.
- W4306291514 hasAuthorship W4306291514A5019785797 @default.
- W4306291514 hasAuthorship W4306291514A5032190373 @default.
- W4306291514 hasAuthorship W4306291514A5035316895 @default.
- W4306291514 hasAuthorship W4306291514A5047463829 @default.
- W4306291514 hasAuthorship W4306291514A5047487046 @default.
- W4306291514 hasAuthorship W4306291514A5047509842 @default.
- W4306291514 hasAuthorship W4306291514A5064317694 @default.
- W4306291514 hasAuthorship W4306291514A5070498614 @default.
- W4306291514 hasAuthorship W4306291514A5076026075 @default.
- W4306291514 hasAuthorship W4306291514A5083963070 @default.
- W4306291514 hasAuthorship W4306291514A5086775048 @default.
- W4306291514 hasAuthorship W4306291514A5088634717 @default.
- W4306291514 hasBestOaLocation W43062915141 @default.
- W4306291514 hasConcept C121608353 @default.
- W4306291514 hasConcept C126322002 @default.
- W4306291514 hasConcept C134018914 @default.