FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306291808> ?p ?o ?g. }

• W4306291808 abstract "Abstract Protein kinases and their substrates form signaling networks partitioned across subcellular compartments to facilitate critical biological processes. While the subcellular roles of many individual kinases have been elucidated, a comprehensive assessment of the synaptic subkinome is lacking. Further, most studies of kinases focus on transcript, protein, and/or phospho-protein expression levels, providing an indirect measure of protein kinase activity. Prior work suggests that gene expression levels are not a good predictor of protein function. Thus, we assessed global serine/threonine protein kinase activity profiles in synaptosomal, nuclear, and cytosolic fractions from rat frontal cortex homogenate using peptide arrays. Comparisons made between fractions demonstrated differences in overall protein kinase activity. Upstream kinase analysis revealed a list of cognate kinases that were enriched in the synaptosomal fraction compared to the nuclear fraction. We identified many kinases in the synaptic fraction previously implicated in this compartment, while also identifying other kinases with little or no evidence for synaptic localization. Our results show the feasibility of assessing subcellular fractions with peptide activity arrays, as well as suggesting compartment specific activity profiles associated with established and novel kinases." @default.
• W4306291808 created "2022-10-15" @default.
• W4306291808 creator A5003040404 @default.
• W4306291808 creator A5015585257 @default.
• W4306291808 creator A5028963541 @default.
• W4306291808 creator A5028977789 @default.
• W4306291808 creator A5048739282 @default.
• W4306291808 creator A5062841660 @default.
• W4306291808 creator A5067854280 @default.
• W4306291808 date "2022-10-15" @default.
• W4306291808 modified "2023-10-14" @default.
• W4306291808 title "Subcellular partitioning of protein kinase activity revealed by functional kinome profiling" @default.
• W4306291808 cites W1969054252 @default.
• W4306291808 cites W1992735813 @default.
• W4306291808 cites W2003982930 @default.
• W4306291808 cites W2027419062 @default.
• W4306291808 cites W2067176875 @default.
• W4306291808 cites W2082443574 @default.
• W4306291808 cites W2089351762 @default.
• W4306291808 cites W2093105397 @default.
• W4306291808 cites W2106969175 @default.
• W4306291808 cites W2109779479 @default.
• W4306291808 cites W2145493769 @default.
• W4306291808 cites W2506540428 @default.
• W4306291808 cites W2513387691 @default.
• W4306291808 cites W2743307433 @default.
• W4306291808 cites W2749039461 @default.
• W4306291808 cites W2751044183 @default.
• W4306291808 cites W2900569176 @default.
• W4306291808 cites W2946518831 @default.
• W4306291808 cites W2948949781 @default.
• W4306291808 cites W2999287481 @default.
• W4306291808 cites W3007219438 @default.
• W4306291808 cites W3080507031 @default.
• W4306291808 cites W3104378422 @default.
• W4306291808 cites W3145969289 @default.
• W4306291808 cites W4206727477 @default.
• W4306291808 cites W4225015696 @default.
• W4306291808 doi "https://doi.org/10.1038/s41598-022-21026-5" @default.
• W4306291808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36243751" @default.
• W4306291808 hasPublicationYear "2022" @default.
• W4306291808 type Work @default.
• W4306291808 citedByCount "1" @default.
• W4306291808 countsByYear W43062918082023 @default.
• W4306291808 crossrefType "journal-article" @default.
• W4306291808 hasAuthorship W4306291808A5003040404 @default.
• W4306291808 hasAuthorship W4306291808A5015585257 @default.
• W4306291808 hasAuthorship W4306291808A5028963541 @default.
• W4306291808 hasAuthorship W4306291808A5028977789 @default.
• W4306291808 hasAuthorship W4306291808A5048739282 @default.
• W4306291808 hasAuthorship W4306291808A5062841660 @default.
• W4306291808 hasAuthorship W4306291808A5067854280 @default.
• W4306291808 hasBestOaLocation W43062918081 @default.
• W4306291808 hasConcept C104317684 @default.
• W4306291808 hasConcept C111368507 @default.
• W4306291808 hasConcept C11960822 @default.
• W4306291808 hasConcept C127313418 @default.
• W4306291808 hasConcept C181199279 @default.
• W4306291808 hasConcept C184235292 @default.
• W4306291808 hasConcept C203635412 @default.
• W4306291808 hasConcept C2776414213 @default.
• W4306291808 hasConcept C2776879804 @default.
• W4306291808 hasConcept C54174078 @default.
• W4306291808 hasConcept C55493867 @default.
• W4306291808 hasConcept C86803240 @default.
• W4306291808 hasConcept C87325107 @default.
• W4306291808 hasConcept C95444343 @default.
• W4306291808 hasConcept C97029542 @default.
• W4306291808 hasConcept C98539663 @default.
• W4306291808 hasConceptScore W4306291808C104317684 @default.
• W4306291808 hasConceptScore W4306291808C111368507 @default.
• W4306291808 hasConceptScore W4306291808C11960822 @default.
• W4306291808 hasConceptScore W4306291808C127313418 @default.
• W4306291808 hasConceptScore W4306291808C181199279 @default.
• W4306291808 hasConceptScore W4306291808C184235292 @default.
• W4306291808 hasConceptScore W4306291808C203635412 @default.
• W4306291808 hasConceptScore W4306291808C2776414213 @default.
• W4306291808 hasConceptScore W4306291808C2776879804 @default.
• W4306291808 hasConceptScore W4306291808C54174078 @default.
• W4306291808 hasConceptScore W4306291808C55493867 @default.
• W4306291808 hasConceptScore W4306291808C86803240 @default.
• W4306291808 hasConceptScore W4306291808C87325107 @default.
• W4306291808 hasConceptScore W4306291808C95444343 @default.
• W4306291808 hasConceptScore W4306291808C97029542 @default.
• W4306291808 hasConceptScore W4306291808C98539663 @default.
• W4306291808 hasFunder F4320332161 @default.
• W4306291808 hasFunder F4320337346 @default.
• W4306291808 hasIssue "1" @default.
• W4306291808 hasLocation W43062918081 @default.
• W4306291808 hasLocation W43062918082 @default.
• W4306291808 hasLocation W43062918083 @default.
• W4306291808 hasLocation W43062918084 @default.
• W4306291808 hasOpenAccess W4306291808 @default.
• W4306291808 hasPrimaryLocation W43062918081 @default.
• W4306291808 hasRelatedWork W1520436089 @default.
• W4306291808 hasRelatedWork W1589508537 @default.
• W4306291808 hasRelatedWork W1640595204 @default.
• W4306291808 hasRelatedWork W1997385729 @default.
• W4306291808 hasRelatedWork W2064910808 @default.
• W4306291808 hasRelatedWork W2739321151 @default.

• next