FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306293826> ?p ?o ?g. }

• W4306293826 abstract "Although lung diseases typically result from long-term exposures, even a robust, one-time exposure can result in long-lasting consequences. Endotoxin is a ubiquitous environmental/occupational inflammatory agent often used to model airway inflammation. Using a murine model, the return to lung homeostasis following high dose inhalant lipopolysaccharide (LPS, 10-100 μg) exposure were delineated over 2 weeks. LPS-induced rapid weight loss, release of proinflammatory mediators, and inflammatory cell influx with prolonged persistence of activated macrophages CD11c+CD11b+ and recruited/transitioning CD11cintCD11b+ monocyte-macrophages out to 2 weeks. Next, lung-delivered recombinant (r) interleukin (IL)-10 was intratracheally administered for 3 doses initiated 5 h following LPS (10 μg) exposure for 2 days. IL-10 therapy reduced LPS-induced weight loss and increased blood glucose levels. Whereas there was no difference in LPS-induced bronchoalveolar lavage airway fluid cellular influx, total lung cell infiltrates were reduced (37%) with rIL-10 treatment. Post-LPS exposure treatment with rIL-10 strikingly reduced lavage fluid and lung homogenate levels of tumor necrosis factor-α (88% and 93% reduction, respectively), IL-6 (98% and 94% reduction), CXCL1 (66% and 75% reduction), and CXCL2 (47% and 67% reduction). LPS-induced recruited monocyte-macrophages (CD11cintCD11b+) were reduced (68%) with rIL-10. Correspondingly, LPS-induced lung tissue CCR2+ inflammatory monocyte-macrophage were reduced with rIL-10. There were also reductions in LPS-induced lung neutrophils, lymphocyte subpopulations, collagen content, and vimentin expression. These findings support the importance of studying resolution processes for the development of treatment after unintended environmental/occupational biohazard exposures. Short-term, lung-delivered rIL-10 favorably hastened inflammatory recovery processes following acute, high dose inhalant LPS exposure." @default.
• W4306293826 created "2022-10-15" @default.
• W4306293826 creator A5024763480 @default.
• W4306293826 creator A5030545609 @default.
• W4306293826 creator A5041548914 @default.
• W4306293826 creator A5046175017 @default.
• W4306293826 creator A5074351809 @default.
• W4306293826 creator A5081979846 @default.
• W4306293826 creator A5084648166 @default.
• W4306293826 date "2022-10-15" @default.
• W4306293826 modified "2023-10-06" @default.
• W4306293826 title "Post-endotoxin exposure-induced lung inflammation and resolution consequences beneficially impacted by lung-delivered IL-10 therapy" @default.
• W4306293826 cites W1485015213 @default.
• W4306293826 cites W1518645559 @default.
• W4306293826 cites W1547680175 @default.
• W4306293826 cites W1568363150 @default.
• W4306293826 cites W1982379013 @default.
• W4306293826 cites W1994172328 @default.
• W4306293826 cites W2010472544 @default.
• W4306293826 cites W2028899642 @default.
• W4306293826 cites W2030458379 @default.
• W4306293826 cites W2052298404 @default.
• W4306293826 cites W2095924943 @default.
• W4306293826 cites W2102602766 @default.
• W4306293826 cites W2124234305 @default.
• W4306293826 cites W2129271699 @default.
• W4306293826 cites W2149659037 @default.
• W4306293826 cites W2151345786 @default.
• W4306293826 cites W2166135591 @default.
• W4306293826 cites W2191319622 @default.
• W4306293826 cites W2237982598 @default.
• W4306293826 cites W2289651151 @default.
• W4306293826 cites W2314659951 @default.
• W4306293826 cites W2548988343 @default.
• W4306293826 cites W2611803877 @default.
• W4306293826 cites W2736034593 @default.
• W4306293826 cites W2754096498 @default.
• W4306293826 cites W2765859637 @default.
• W4306293826 cites W2769288249 @default.
• W4306293826 cites W2769807545 @default.
• W4306293826 cites W2778449918 @default.
• W4306293826 cites W2797190151 @default.
• W4306293826 cites W2889270757 @default.
• W4306293826 cites W2901007564 @default.
• W4306293826 cites W2906021714 @default.
• W4306293826 cites W2913858653 @default.
• W4306293826 cites W2938211484 @default.
• W4306293826 cites W2938341288 @default.
• W4306293826 cites W2973009393 @default.
• W4306293826 cites W3041747367 @default.
• W4306293826 cites W3127925863 @default.
• W4306293826 cites W3179501149 @default.
• W4306293826 cites W3197060826 @default.
• W4306293826 cites W4283072731 @default.
• W4306293826 cites W943598279 @default.
• W4306293826 doi "https://doi.org/10.1038/s41598-022-22346-2" @default.
• W4306293826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36243830" @default.
• W4306293826 hasPublicationYear "2022" @default.
• W4306293826 type Work @default.
• W4306293826 citedByCount "2" @default.
• W4306293826 countsByYear W43062938262023 @default.
• W4306293826 crossrefType "journal-article" @default.
• W4306293826 hasAuthorship W4306293826A5024763480 @default.
• W4306293826 hasAuthorship W4306293826A5030545609 @default.
• W4306293826 hasAuthorship W4306293826A5041548914 @default.
• W4306293826 hasAuthorship W4306293826A5046175017 @default.
• W4306293826 hasAuthorship W4306293826A5074351809 @default.
• W4306293826 hasAuthorship W4306293826A5081979846 @default.
• W4306293826 hasAuthorship W4306293826A5084648166 @default.
• W4306293826 hasBestOaLocation W43062938261 @default.
• W4306293826 hasConcept C104317684 @default.
• W4306293826 hasConcept C126322002 @default.
• W4306293826 hasConcept C127716648 @default.
• W4306293826 hasConcept C13373296 @default.
• W4306293826 hasConcept C164027704 @default.
• W4306293826 hasConcept C17991360 @default.
• W4306293826 hasConcept C185592680 @default.
• W4306293826 hasConcept C203014093 @default.
• W4306293826 hasConcept C2776914184 @default.
• W4306293826 hasConcept C2777714996 @default.
• W4306293826 hasConcept C2777961210 @default.
• W4306293826 hasConcept C2778754761 @default.
• W4306293826 hasConcept C2779919695 @default.
• W4306293826 hasConcept C2781184567 @default.
• W4306293826 hasConcept C55493867 @default.
• W4306293826 hasConcept C71924100 @default.
• W4306293826 hasConcept C96525457 @default.
• W4306293826 hasConceptScore W4306293826C104317684 @default.
• W4306293826 hasConceptScore W4306293826C126322002 @default.
• W4306293826 hasConceptScore W4306293826C127716648 @default.
• W4306293826 hasConceptScore W4306293826C13373296 @default.
• W4306293826 hasConceptScore W4306293826C164027704 @default.
• W4306293826 hasConceptScore W4306293826C17991360 @default.
• W4306293826 hasConceptScore W4306293826C185592680 @default.
• W4306293826 hasConceptScore W4306293826C203014093 @default.
• W4306293826 hasConceptScore W4306293826C2776914184 @default.
• W4306293826 hasConceptScore W4306293826C2777714996 @default.
• W4306293826 hasConceptScore W4306293826C2777961210 @default.
• W4306293826 hasConceptScore W4306293826C2778754761 @default.
• W4306293826 hasConceptScore W4306293826C2779919695 @default.

• next